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    Pigh phosphatidylinositol glycan anchor biosynthesis, class H [ Mus musculus (house mouse) ]

    Gene ID: 110417, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Pighprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Hprovided by MGI
    Primary source
    MGI:MGI:99463
    See related
    Ensembl:ENSMUSG00000021120 AllianceGenome:MGI:99463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIG-H; 2210416H01Rik; A930028P05Rik
    Summary
    Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in cytoplasm. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human PIGH (phosphatidylinositol glycan anchor biosynthesis class H). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 13.4), placenta adult (RPKM 9.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 C3; 12 35.51 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (79127443..79136478, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (79080669..79089753, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32582 Neighboring gene transmembrane protein 229B Neighboring gene STARR-seq mESC enhancer starr_32583 Neighboring gene STARR-seq mESC enhancer starr_32585 Neighboring gene STARR-seq mESC enhancer starr_32589 Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 Neighboring gene predicted gene, 53729 Neighboring gene RIKEN cDNA 9230116L04 gene Neighboring gene STARR-positive B cell enhancer ABC_E10760 Neighboring gene STARR-seq mESC enhancer starr_32591 Neighboring gene ribosomal protein large PO subunit pseudogene Neighboring gene arginase type II Neighboring gene predicted gene, 40462

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria. Ware RE, et al. Blood, 1994 Jun 15. PMID 8204896
    2. Chromosomal mapping of Adam9, Adam15 and Adam21. Seldin MF, et al. Matrix Biol, 2000 May. PMID 10842103
    3. Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains. Wergedal JE, et al. J Lipid Res, 2007 Aug. PMID 17496333
    4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102258

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol N-acetylglucosaminyltransferase subunit H
    Names
    phosphatidylinositol glycan, class H
    phosphatidylinositol-glycan biosynthesis class H protein
    NP_084264.1
    XP_030102381.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428964.1 → NP_001415893.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165249

    2. NM_029988.3 → NP_084264.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform 1

      See identical proteins and their annotated locations for NP_084264.1

      Status: VALIDATED

      Source sequence(s)
      AC165249
      Consensus CDS
      CCDS26006.1
      UniProtKB/Swiss-Prot
      Q5M9N4
      UniProtKB/TrEMBL
      Q8BMJ9
      Related
      ENSMUSP00000072018.8, ENSMUST00000072154.9
      Conserved Domains (1) summary
      pfam10181
      Location:90 → 158
      PIG-H; GPI-GlcNAc transferase complex, PIG-H component

    RNA

    1. NR_190557.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC165249

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      79127443..79136478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246521.2 → XP_030102381.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform X1

      Conserved Domains (1) summary
      pfam10181
      Location:27 → 96
      PIG-H; GPI-GlcNAc transferase complex, PIG-H component
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M9N4.1 GenPept UniProtKB/Swiss-Prot:Q5M9N4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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