F11 coagulation factor XI [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: F11provided by MGI
Official Full Name: coagulation factor XIprovided by MGI
Primary source: MGI:MGI:99481
See related: Ensembl:ENSMUSG00000031645 AllianceGenome:MGI:99481
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FXI; PTA; Cf11; 1600027G01Rik
Summary: This gene encodes a glycoprotein coagulation factor that plays an important role in intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that can be activated by coagulation factor XIIa, thrombin or factor XIa to generate active factor XIa protease. Mice lacking the encoded protein display a survival advantage during peritoneal sepsis and resist inflammation and bacterial accumulation upon infection with Listeria. [provided by RefSeq, Apr 2015]
Expression: Biased expression in liver E18 (RPKM 33.2), liver adult (RPKM 6.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B1.1; 8 25.14 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (45693696..45715092, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (45240659..45262055, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation.
Title: Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation.
A non-circulating pool of factor XI associated with glycosaminoglycans in mice.
Title: A non-circulating pool of factor XI associated with glycosaminoglycans in mice.
interfering with the FXIIa-FXI interaction could inhibit thromboinflammatory processes without compromising hemostasis. Inhibiting FXI activation with anti-FXI antibody 14E11 reduces myocardial ischemia-reperfusion injury.
Title: Factor XI contributes to myocardial ischemia-reperfusion injury in mice.
FXI(-/-) mice have a mild hemostatic defect after injury to the saphenous vein but not after transection of the tail or vessels in the abdominal wall.
Title: Factor XI-deficient mice exhibit increased bleeding after injury to the saphenous vein.
FXI protects against sepsis derived from Streptococcus pneumoniae or Klebsiella pneumoniae pneumonia at least in part by enhancing the phagocytic capacity of neutrophils by a mechanism that is independent of activation via FXIIa.
Title: Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation.
FXI attenuates part of the allergic response to repeated administration of house dust mite in the airways by a mechanism that is independent of activation via FXII.
Title: Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII.
Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.
Title: Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.
FXI deprivation was shown to slow down atherogenesis in Apoe knockout mice.
Title: Factor XI Deficiency Protects Against Atherogenesis in Apolipoprotein E/Factor XI Double Knockout Mice.
anion-binding sites on FXIa that are required for expression of heparin's cofactor activity during protease inhibition by antithrombin are also required for expression of polyP cofactor activity during FXI activation
Title: Factor XI anion-binding sites are required for productive interactions with polyphosphate.
Factor XI antisense oligonucleotides safely prevent thrombus formation on acutely ruptured atherosclerotic plaques in mice.
Title: Factor XI regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type aminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemostasis	IEA Inferred from Electronic Annotation more info
involved_in plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coagulation factor XI

Names: plasma thromboplastin antecedent

NP_001398594.1

EC 3.4.21.27

NP_082342.1

EC 3.4.21.27

XP_006509308.1

EC 3.4.21.27

XP_011240474.1

EC 3.4.21.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411665.1 → NP_001398594.1 coagulation factor XI isoform 2

Status: REVIEWED

Source sequence(s)

AC120003
NM_028066.3 → NP_082342.1 coagulation factor XI isoform 1 preproprotein

See identical proteins and their annotated locations for NP_082342.1

Status: REVIEWED

Source sequence(s)

AC120003

Consensus CDS

CCDS22274.1

UniProtKB/Swiss-Prot

Q91Y47, Q9DAT3

Related

ENSMUSP00000034064.4, ENSMUST00000034064.5

Conserved Domains (3) summary

smart00223
Location:200 → 283

APPLE; APPLE domain

smart00020
Location:389 → 617

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:390 → 617

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

45693696..45715092 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509245.3 → XP_006509308.1 coagulation factor XI isoform X2

Conserved Domains (3) summary

smart00223
Location:130 → 213

APPLE; APPLE domain

cd00190
Location:320 → 547

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

cl00112
Location:6 → 33

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
XM_011242172.2 → XP_011240474.1 coagulation factor XI isoform X3

Conserved Domains (2) summary

smart00223
Location:87 → 170

APPLE; APPLE domain

cd00190
Location:277 → 504

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...