Glo1 glyoxalase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glo1provided by MGI
Official Full Name: glyoxalase 1provided by MGI
Primary source: MGI:MGI:95742
See related: Ensembl:ENSMUSG00000024026 AllianceGenome:MGI:95742
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GLY1; Qglo; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s; 0610009E22Rik; 1110008E19Rik; 2510049H23Rik
Summary: Enables lactoylglutathione lyase activity and zinc ion binding activity. Involved in osteoclast differentiation. Acts upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver adult (RPKM 62.5), liver E18 (RPKM 45.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 15.69 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (30811835..30831633, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (30592861..30612659, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpressing glyoxalase 1 attenuates acute hyperglycemia-exacerbated neurological deficits of ischemic stroke in mice.
Title: Overexpressing glyoxalase 1 attenuates acute hyperglycemia-exacerbated neurological deficits of ischemic stroke in mice.
Glyoxalase 1 knockdown induces age-related beta-cell dysfunction and glucose intolerance in mice.
Title: Glyoxalase 1 knockdown induces age-related β-cell dysfunction and glucose intolerance in mice.
Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex.
Title: Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex.
Phosphorylation of T107 by CamKIIdelta Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1.
Title: Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1.
RAGE-independent up-regulation of Glo1 in RAGE-KO mice might be as another explanation for, at least some, effects attributed to RAGE before.
Title: Gene doubling increases glyoxalase 1 expression in RAGE knockout mice.
The protein expression of GLO1 in basilar arteries from hypertensive mice was decreased, and GLO1 expression was negatively correlated with medial cross-sectional area and blood pressure in basilar arteries during hypertension.
Title: Reduction of glyoxalase 1 (GLO1) aggravates cerebrovascular remodeling via promoting the proliferation of basilar smooth muscle cells in hypertension.
Data suggest that GLO1 rescues bone marrow-derived progenitor cell dysfunction and facilitates wound healing in diabetic animals, at least partly through preventing methylglyoxal-induced impairment of IRE1alpha expression and activity.
Title: Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.
The objective of the present study was to detect whether overexpression of methylglyoxal-metabolizing enzyme glyoxalase-1 (GLO1), which reduces reactive oxygen species in Diabetic Adipose-Derived Stem Cells, can restore their proangiogenic function in a streptozotocin-induced diabetic mice model of critical limb ischemia.
Title: Glyoxalase-1 Overexpression Reverses Defective Proangiogenic Function of Diabetic Adipose-Derived Stem Cells in Streptozotocin-Induced Diabetic Mice Model of Critical Limb Ischemia.
Transgenic mice overexpressing Glo1 on both FVB/NJ (FVB) or C57BL/6J (B6) backgrounds showed increased voluntary EtOH consumption compared to their wild-type littermates. Transgenic Glo1 knockdown mice on a B6 background showed decreased voluntary EtOH consumption. Genetic manipulations of Glo1 had no effect on sucrose, saccharin or water consumption.
Title: Genetic and pharmacological manipulation of glyoxalase 1 regulates voluntary ethanol consumption in mice.
the Glo1-methylglyoxal pathway integrates maternal and neural precursor cell metabolism to regulate neural development.
Title: A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (2)
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237613

AW550643 (e-PCR)
- UniSTS:180988

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lactoylglutathione lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables lactoylglutathione lyase activity	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	IC Inferred by Curator more info	PubMed
involved_in methylglyoxal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lactoylglutathione lyase

Names: S-D-lactoylglutathione methylglyoxal lyase; aldoketomutase; glx I; glyoxalase 1 complex; glyoxalase 1 regulatory; glyoxalase 1 structural; glyoxalase I; ketone-aldehyde mutase; methylglyoxalase

NP_001107032.1

EC 4.4.1.5

NP_079650.3

EC 4.4.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113560.1 → NP_001107032.1 lactoylglutathione lyase

See identical proteins and their annotated locations for NP_001107032.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AK049703, BG077218, BP769280, BY312309

Consensus CDS

CCDS28600.1

UniProtKB/Swiss-Prot

Q543L3, Q8R3T1, Q9CPU0

UniProtKB/TrEMBL

A5GZX3

Related

ENSMUSP00000126586.2, ENSMUST00000167624.2

Conserved Domains (1) summary

PLN03042
Location:20 → 184

PLN03042; Lactoylglutathione lyase; Provisional
NM_025374.3 → NP_079650.3 lactoylglutathione lyase

See identical proteins and their annotated locations for NP_079650.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AK049703, BP769280, BY312309

Consensus CDS

CCDS28600.1

UniProtKB/Swiss-Prot

Q543L3, Q8R3T1, Q9CPU0

UniProtKB/TrEMBL

A5GZX3

Related

ENSMUSP00000158296.2, ENSMUST00000236335.2

Conserved Domains (1) summary

PLN03042
Location:20 → 184

PLN03042; Lactoylglutathione lyase; Provisional