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    Clps colipase, pancreatic [ Mus musculus (house mouse) ]

    Gene ID: 109791, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Clpsprovided by MGI
    Official Full Name
    colipase, pancreaticprovided by MGI
    Primary source
    MGI:MGI:88421
    See related
    Ensembl:ENSMUSG00000024225 AllianceGenome:MGI:88421
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2200003J09Rik
    Summary
    This gene encodes a member of the colipase family of coenzymes that is required for the optimal activity of pancreatic lipase. The encoded protein undergoes proteolytic processing to generate a mature polypeptide that binds to the lipase and prevents inhibition by bile acids. Over half of the mice lacking the encoded protein die within two weeks of birth while the remaining ones exhibit fat malabsorption and altered body weight regulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]
    Expression
    Restricted expression toward stomach adult (RPKM 112946.0) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 14.76 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28777184..28779740, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28558210..28560766, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41506 Neighboring gene armadillo repeat containing 12 Neighboring gene STARR-seq mESC enhancer starr_42217 Neighboring gene colipase-like 2 Neighboring gene microRNA 6969 Neighboring gene STARR-seq mESC enhancer starr_42221 Neighboring gene lipoma HMGIC fusion partner-like 5 Neighboring gene STARR-seq mESC enhancer starr_42224 Neighboring gene serine/arginine-rich protein specific kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice. Miller R, et al. Am J Physiol Endocrinol Metab, 2009 Oct. PMID 19622781, Free PMC Article
    2. Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice. D'Agostino D, et al. J Biol Chem, 2002 Mar 1. PMID 11751900, Free PMC Article
    3. The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver. Pang W, et al. J Lipid Res, 2011 May. PMID 21339507, Free PMC Article
    4. Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. Davis RC, et al. Genomics, 1991 May. PMID 2045105
    5. Quantitative trait loci for carbohydrate and total energy intake on mouse chromosome 17: congenic strain confirmation and candidate gene analyses (Glo1, Glp1r). Kumar KG, et al. Am J Physiol Regul Integr Comp Physiol, 2007 Jan. PMID 16946080

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that the conditional expression of mPlrp2 and mClps is involved in the hydrolysis of retinyl esters in the mouse liver.
      Title: The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver.
    2. colipase (-/-)mice develop diet-induced obesity, as do colipase (+/+) mice, and have normal responses to a two-macronutrient choice diet and to a switch from a high-fat to a low-fat diet
      Title: Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice.
    3. We conclude that, in addition to its critical role in fat digestion, procolipase has essential functions in postnatal development and in regulating body weight set point.
      Title: Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within digestion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to food IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    colipase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317065.1 → NP_001303994.1  colipase isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
      Source sequence(s)
      AK008815, BM570078, BQ126290
      Consensus CDS
      CCDS84287.1
      UniProtKB/TrEMBL
      B2KF29
      Related
      ENSMUSP00000110433.2, ENSMUST00000114785.3
      Conserved Domains (2) summary
      smart00023
      Location:19 → 72
      COLIPASE; Colipase
      cl24053
      Location:30 → 67
      COLIPASE; Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation

    2. NM_025469.3 → NP_079745.1  colipase isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_079745.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK008815, BM570078, BQ126290
      Consensus CDS
      CCDS28581.1
      UniProtKB/Swiss-Prot
      Q8VHR2, Q8VHR3, Q9CQC2
      UniProtKB/TrEMBL
      Q9D2R7
      Related
      ENSMUSP00000025062.4, ENSMUST00000025062.5
      Conserved Domains (2) summary
      cd00039
      Location:19 → 108
      COLIPASE; Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation
      smart00023
      Location:19 → 113
      COLIPASE; Colipase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28777184..28779740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQC2.1 GenPept UniProtKB/Swiss-Prot:Q9CQC2

    Gene LinkOut

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    Chemical Information
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