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    Pgm3 phosphoglucomutase 3 [ Mus musculus (house mouse) ]

    Gene ID: 109785, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pgm3provided by MGI
    Official Full Name
    phosphoglucomutase 3provided by MGI
    Primary source
    MGI:MGI:97566
    See related
    Ensembl:ENSMUSG00000056131 AllianceGenome:MGI:97566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Agm1; PAGM; Pgm-3; 2810473H05Rik
    Summary
    Enables phosphoacetylglucosamine mutase activity and phosphoglucomutase activity. Acts upstream of or within several processes, including UDP-N-acetylglucosamine biosynthetic process; glucose 1-phosphate metabolic process; and spermatogenesis. Is expressed in colon; metanephros; ovary; and testis. Human ortholog(s) of this gene implicated in immunodeficiency 23 and teratoma. Orthologous to human PGM3 (phosphoglucomutase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 9.9), CNS E18 (RPKM 5.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 E3.1; 9 46.58 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (86423997..86453927, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (86552476..86571878, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1553 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24831 Neighboring gene STARR-seq mESC enhancer starr_24832 Neighboring gene sorting nexin 4 pseudogene Neighboring gene ubiquitin protein ligase E3D Neighboring gene DOP1 leucine zipper like protein A Neighboring gene STARR-positive B cell enhancer ABC_E9332 Neighboring gene STARR-positive B cell enhancer ABC_E10572 Neighboring gene RWD domain containing 2A Neighboring gene malic enzyme 1, NADP(+)-dependent, cytosolic Neighboring gene STARR-seq mESC enhancer starr_24835 Neighboring gene RIKEN cDNA A330041J22 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Greig KT, et al. Mol Cell Biol, 2007 Aug. PMID 17548465, Free PMC Article
    2. Genetic mapping and systematic screening of mouse endogenously imprinted loci detected with restriction landmark genome scanning method (RLGS). Shibata H, et al. Mamm Genome, 1994 Dec. PMID 7894162
    3. A null mutation at the mouse Phosphoglucomutase-1 locus and a new locus Pgm-3. Johnson FM, et al. Biochem Genet, 1981 Jun. PMID 6457600
    4. The Pk-3 gene determines both the heart, M1, and the kidney, M2, pyruvate kinase isozymes in the mouse; and a simple electrophoretic method for separating phosphoglucomutase-3. Peters J, et al. Biochem Genet, 1984 Dec. PMID 6241468
    5. A malic enzyme probe detects cross-hybridizing sequences closely linked to loci encoding other metabolic enzymes. Cobb RR, et al. Genomics, 1992 Feb. PMID 1346782

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables intramolecular phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoacetylglucosamine mutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoacetylglucosamine mutase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphoacetylglucosamine mutase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within UDP-N-acetylglucosamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in UDP-N-acetylglucosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryo development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemopoiesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organic substance metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoacetylglucosamine mutase
    Names
    GlcNAc-P mutase
    N-acetylglucosamine-phosphate mutase
    PGM 3
    acetylglucosamine phosphomutase
    NP_001157218.1
    NP_082628.3
    XP_030099867.1
    XP_036010453.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163746.1 → NP_001157218.1  phosphoacetylglucosamine mutase isoform 2

      See identical proteins and their annotated locations for NP_001157218.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC157998, AK028066, AK043547, AK049758
      Consensus CDS
      CCDS52877.1
      UniProtKB/TrEMBL
      Q3TFH8, Q8BWW3, Q8BZ65
      Related
      ENSMUSP00000072390.7, ENSMUST00000072585.8
      Conserved Domains (2) summary
      cd03086
      Location:22 → 486
      PGM3; PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into ...
      PLN02895
      Location:1 → 497
      PLN02895; phosphoacetylglucosamine mutase

    2. NM_028352.4 → NP_082628.3  phosphoacetylglucosamine mutase isoform 1

      See identical proteins and their annotated locations for NP_082628.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC157998, AK028066, AK043547, AK160913
      Consensus CDS
      CCDS23381.1
      UniProtKB/Swiss-Prot
      B2RS40, Q543F9, Q9CYR6
      UniProtKB/TrEMBL
      Q3TFH8, Q8BZ65
      Related
      ENSMUSP00000070871.5, ENSMUST00000070064.11
      Conserved Domains (2) summary
      cd03086
      Location:22 → 527
      PGM3; PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into ...
      PLN02895
      Location:1 → 538
      PLN02895; phosphoacetylglucosamine mutase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      86423997..86453927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154560.1 → XP_036010453.1  phosphoacetylglucosamine mutase isoform X1

      UniProtKB/TrEMBL
      Q8BME1
      Conserved Domains (1) summary
      cd03086
      Location:22 → 513
      PGM3; PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into ...

    2. XM_030244007.2 → XP_030099867.1  phosphoacetylglucosamine mutase isoform X2

      Conserved Domains (1) summary
      cl38939
      Location:2 → 262
      phosphohexomutase; The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine ...

    RNA

    1. XR_003947761.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYR6.1 GenPept UniProtKB/Swiss-Prot:Q9CYR6

    Gene LinkOut

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