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    Slc5a10 solute carrier family 5 (sodium/glucose cotransporter), member 10 [ Mus musculus (house mouse) ]

    Gene ID: 109342, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc5a10provided by MGI
    Official Full Name
    solute carrier family 5 (sodium/glucose cotransporter), member 10provided by MGI
    Primary source
    MGI:MGI:1926089
    See related
    Ensembl:ENSMUSG00000042371 AllianceGenome:MGI:1926089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SGLT5; C330021F16Rik
    Summary
    Predicted to enable glucose:sodium symporter activity. Predicted to be involved in sodium ion transport. Predicted to act upstream of or within ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Orthologous to human SLC5A10 (solute carrier family 5 member 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 128.6) and large intestine adult (RPKM 4.5) See more
    Orthologs
    human all
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    Genomic context

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    See Slc5a10 in Genome Data Viewer
    Location:
    11 B2; 11 37.96 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61563608..61611641, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61672782..61720817, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene B9 protein domain 1, opposite strand Neighboring gene B9 protein domain 1 Neighboring gene epsin 2 Neighboring gene STARR-seq mESC enhancer starr_29682 Neighboring gene STARR-positive B cell enhancer ABC_E3957 Neighboring gene STARR-positive B cell enhancer ABC_E3958 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:61483303-61483412 Neighboring gene GRB2-related adaptor protein Neighboring gene family with sequence similarity 83, member G Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2 Neighboring gene STARR-seq mESC enhancer starr_29688 Neighboring gene unc-51 like kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose. Fukuzawa T, et al. PLoS One, 2013. PMID 23451068, Free PMC Article
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show fructose-induced hepatic steatosis was exacerbated in the SGLT5-deficient mice
      Title: SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fructose:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucose:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannose:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sodium/mannose cotransporter SLC5A10
    Names
    Na(+)/glucose cotransporter 5
    sodium/glucose cotransporter 5
    solute carrier family 5 member 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033227.2 → NP_001028399.1  sodium/mannose cotransporter SLC5A10

      See identical proteins and their annotated locations for NP_001028399.1

      Status: VALIDATED

      Source sequence(s)
      AK144033
      Consensus CDS
      CCDS24818.1
      UniProtKB/Swiss-Prot
      B9EJ50, Q5SWY8
      UniProtKB/TrEMBL
      F6UXY4
      Related
      ENSMUSP00000054407.5, ENSMUST00000051552.11
      Conserved Domains (1) summary
      cl00456
      Location:17 → 596
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001382268.1 → NP_001369197.1  sodium/mannose cotransporter SLC5A10

      Status: VALIDATED

      Source sequence(s)
      AL596209
      UniProtKB/Swiss-Prot
      B9EJ50, Q5SWY8
      UniProtKB/TrEMBL
      F6UXY4
      Related
      ENSMUSP00000114523.2, ENSMUST00000148584.2
      Conserved Domains (1) summary
      cl00456
      Location:17 → 596
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61563608..61611641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531980.5 → XP_006532043.1  sodium/mannose cotransporter SLC5A10 isoform X3

      See identical proteins and their annotated locations for XP_006532043.1

      UniProtKB/Swiss-Prot
      B9EJ50, Q5SWY8
      UniProtKB/TrEMBL
      F6UXY4
      Conserved Domains (1) summary
      cl00456
      Location:17 → 596
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_006531979.5 → XP_006532042.1  sodium/mannose cotransporter SLC5A10 isoform X2

      UniProtKB/TrEMBL
      F6UXY4
      Related
      ENSMUSP00000118196.2, ENSMUST00000151780.8
      Conserved Domains (1) summary
      cl00456
      Location:52 → 604
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_006531978.5 → XP_006532041.1  sodium/mannose cotransporter SLC5A10 isoform X1

      UniProtKB/TrEMBL
      F6UXY4
      Conserved Domains (1) summary
      cl00456
      Location:52 → 611
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. XM_006531981.5 → XP_006532044.1  sodium/mannose cotransporter SLC5A10 isoform X4

      Conserved Domains (1) summary
      cl00456
      Location:52 → 363
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SWY8.1 GenPept UniProtKB/Swiss-Prot:Q5SWY8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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