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    R3hdm4 R3H domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 109284, updated on 5-Mar-2024

    Summary

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    Official Symbol
    R3hdm4provided by MGI
    Official Full Name
    R3H domain containing 4provided by MGI
    Primary source
    MGI:MGI:1924814
    See related
    Ensembl:ENSMUSG00000035781 AllianceGenome:MGI:1924814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C030046I01Rik
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be located in nucleus. Orthologous to human R3HDM4 (R3H domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in stomach adult (RPKM 133.4), colon adult (RPKM 121.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 39.72 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79745886..79752764, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79910052..79916930, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 16 Neighboring gene STARR-positive B cell enhancer ABC_E2946 Neighboring gene STARR-positive B cell enhancer ABC_E252 Neighboring gene predicted gene, 24019 Neighboring gene KISS1 receptor Neighboring gene STARR-positive B cell enhancer ABC_E6878 Neighboring gene STARR-positive B cell enhancer ABC_E10625 Neighboring gene predicted gene, 40715

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    R3H domain-containing protein 4
    Names
    R3H domain-containing protein C19orf22 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378997.1 → NP_001365926.1  R3H domain-containing protein 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC151846
      Conserved Domains (2) summary
      pfam01424
      Location:189 → 248
      R3H; R3H domain
      pfam13902
      Location:50 → 177
      R3H-assoc; R3H-associated N-terminal domain

    2. NM_177994.5 → NP_818775.2  R3H domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_818775.2

      Status: VALIDATED

      Source sequence(s)
      AC151846
      Consensus CDS
      CCDS23997.1
      UniProtKB/Swiss-Prot
      Q4VBF2, Q8BJN1, Q8CGD7, Q8JZZ8
      UniProtKB/TrEMBL
      B2RRK4
      Related
      ENSMUSP00000044570.8, ENSMUST00000045628.15
      Conserved Domains (2) summary
      pfam01424
      Location:183 → 242
      R3H; R3H domain
      pfam13902
      Location:50 → 177
      R3H-assoc; R3H-associated N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79745886..79752764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VBF2.1 GenPept UniProtKB/Swiss-Prot:Q4VBF2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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