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    Adtrp androgen dependent TFPI regulating protein [ Mus musculus (house mouse) ]

    Gene ID: 109254, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Adtrpprovided by MGI
    Official Full Name
    androgen dependent TFPI regulating proteinprovided by MGI
    Primary source
    MGI:MGI:1924596
    See related
    Ensembl:ENSMUSG00000058022 AllianceGenome:MGI:1924596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9530008L14Rik
    Summary
    Predicted to enable hydrolase activity. Predicted to be involved in several processes, including cell migration involved in sprouting angiogenesis; negative regulation of secretion by cell; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in caveola and cell surface. Predicted to be active in endomembrane system. Orthologous to human ADTRP (androgen dependent TFPI regulating protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 17.6), kidney adult (RPKM 12.1) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A4; 13 20.61 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (41916621..42001092, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (41763145..41847616, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5082 Neighboring gene predicted gene, 40925 Neighboring gene STARR-seq mESC enhancer starr_34305 Neighboring gene STARR-seq mESC enhancer starr_34306 Neighboring gene STARR-positive B cell enhancer ABC_E7230 Neighboring gene STARR-seq mESC enhancer starr_34308 Neighboring gene STARR-positive B cell enhancer mm9_chr13:41978984-41979285 Neighboring gene predicted gene 10790 Neighboring gene STARR-positive B cell enhancer ABC_E9397 Neighboring gene predicted gene, 22157 Neighboring gene predicted gene, 32555

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Adtrp regulates thermogenic activity of adipose tissue via mediating the secretion of S100b. Li P, et al. Cell Mol Life Sci, 2022 Jul 8. PMID 35804197
    2. Hepatic ADTRP overexpression does not influence lipid and glucose metabolism. Defour M, et al. Am J Physiol Cell Physiol, 2021 Oct 1. PMID 34288722
    3. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice. Erikci Ertunc M, et al. J Biol Chem, 2020 May 1. PMID 32152231, Free PMC Article
    4. Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor Regulating Protein) in Vascular Development and Function. Patel MM, et al. J Am Heart Assoc, 2018 Nov 20. PMID 30571485, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adtrp regulates thermogenic activity of adipose tissue via mediating the secretion of S100b.
      Title: Adtrp regulates thermogenic activity of adipose tissue via mediating the secretion of S100b.
    2. Hepatic ADTRP overexpression does not influence lipid and glucose metabolism.
      Title: Hepatic ADTRP overexpression does not influence lipid and glucose metabolism.
    3. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice.
      Title: AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice.
    4. role in vascular development and function
      Title: Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor Regulating Protein) in Vascular Development and Function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of extracellular matrix constituent secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lymphocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    androgen-dependent TFPI-regulating protein
    Names
    FAHFA hydrolase ADTRP
    androgen-dependent TPF1-regulating protein
    fatty acid esters of hydroxy fatty acids hydrolase ADTRP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145875.1 → NP_001139347.1  androgen-dependent TFPI-regulating protein isoform 2

      See identical proteins and their annotated locations for NP_001139347.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC165263, AK135327, BY719442
      Consensus CDS
      CCDS49250.1
      UniProtKB/Swiss-Prot
      D3Z6U0, Q3UXS3, Q8C138, Q8K180
      Related
      ENSMUSP00000113661.2, ENSMUST00000121404.8
      Conserved Domains (1) summary
      pfam04750
      Location:5 → 216
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    2. NM_175417.4 → NP_780626.1  androgen-dependent TFPI-regulating protein isoform 1

      See identical proteins and their annotated locations for NP_780626.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC165263, AK029025
      Consensus CDS
      CCDS36642.1
      UniProtKB/TrEMBL
      A0A0R4J0W3
      Related
      ENSMUSP00000071899.4, ENSMUST00000072012.10
      Conserved Domains (1) summary
      pfam04750
      Location:37 → 248
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      41916621..42001092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247126.1 → XP_030102986.1  androgen-dependent TFPI-regulating protein isoform X2

      UniProtKB/Swiss-Prot
      D3Z6U0, Q3UXS3, Q8C138, Q8K180
      Conserved Domains (1) summary
      pfam04750
      Location:5 → 216
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    2. XM_006516835.2 → XP_006516898.1  androgen-dependent TFPI-regulating protein isoform X1

      Conserved Domains (1) summary
      pfam04750
      Location:37 → 248
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    3. XM_011244369.2 → XP_011242671.1  androgen-dependent TFPI-regulating protein isoform X3

      Conserved Domains (1) summary
      pfam04750
      Location:37 → 162
      Far-17a_AIG1; FAR-17a/AIG1-like protein

    RNA

    1. XR_003950421.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C138.2 GenPept UniProtKB/Swiss-Prot:Q8C138

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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