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    Fam118b family with sequence similarity 118, member B [ Mus musculus (house mouse) ]

    Gene ID: 109229, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fam118bprovided by MGI
    Official Full Name
    family with sequence similarity 118, member Bprovided by MGI
    Primary source
    MGI:MGI:1924483
    See related
    Ensembl:ENSMUSG00000050471 AllianceGenome:MGI:1924483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ppp4r1l; 2310022O21Rik; 2700018L24Rik; C030004A17Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in Cajal body organization. Predicted to be located in nucleus. Is expressed in central nervous system. Orthologous to human FAM118B (family with sequence similarity 118 member B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 21.9), thymus adult (RPKM 13.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A4; 9 20.12 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35128261..35179172, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35216965..35267875, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Neighboring gene predicted gene, 39318 Neighboring gene STARR-positive B cell enhancer ABC_E6723 Neighboring gene STARR-positive B cell enhancer ABC_E5059 Neighboring gene FAD-dependent oxidoreductase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_23764 Neighboring gene signal recognition particle receptor alpha Neighboring gene STARR-seq mESC enhancer starr_23765 Neighboring gene STARR-positive B cell enhancer ABC_E3823 Neighboring gene RNA pseudouridylate synthase domain containing 4 Neighboring gene RIKEN cDNA 4933422A05 gene Neighboring gene ribosomal protein L36 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM118B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286604.1 → NP_001273533.1  protein FAM118B isoform 1

      See identical proteins and their annotated locations for NP_001273533.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AC160116, AK079397, AK081206
      Consensus CDS
      CCDS22961.1
      UniProtKB/Swiss-Prot
      Q3THR7, Q8BNN4, Q8BT26, Q8C569
      Related
      ENSMUSP00000113537.2, ENSMUST00000121564.8
      Conserved Domains (1) summary
      pfam13289
      Location:158 → 301
      SIR2_2; SIR2-like domain

    2. NM_175411.5 → NP_780620.1  protein FAM118B isoform 2

      See identical proteins and their annotated locations for NP_780620.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 3. It encodes isoform 2, which is shorter, compared to isoform 1.
      Source sequence(s)
      AC160116, AK079397, AK081206
      Consensus CDS
      CCDS22960.1
      UniProtKB/Swiss-Prot
      Q8C569
      Related
      ENSMUSP00000066281.6, ENSMUST00000063782.12
      Conserved Domains (1) summary
      pfam13289
      Location:117 → 225
      SIR2_2; SIR2-like domain

    3. NM_194257.2 → NP_919233.1  protein FAM118B isoform 1

      See identical proteins and their annotated locations for NP_919233.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AC160116, AK079397, AK081206
      Consensus CDS
      CCDS22961.1
      UniProtKB/Swiss-Prot
      Q3THR7, Q8BNN4, Q8BT26, Q8C569
      Related
      ENSMUSP00000058377.8, ENSMUST00000059057.14
      Conserved Domains (1) summary
      pfam13289
      Location:158 → 301
      SIR2_2; SIR2-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      35128261..35179172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244005.2 → XP_030099865.1  protein FAM118B isoform X3

      Conserved Domains (1) summary
      pfam13289
      Location:79 → 225
      SIR2_2; SIR2-like domain

    2. XM_006509938.4 → XP_006510001.1  protein FAM118B isoform X2

      Conserved Domains (1) summary
      pfam13289
      Location:158 → 301
      SIR2_2; SIR2-like domain

    3. XM_036154557.1 → XP_036010450.1  protein FAM118B isoform X2

      Conserved Domains (1) summary
      pfam13289
      Location:158 → 301
      SIR2_2; SIR2-like domain

    4. XM_030244004.2 → XP_030099864.1  protein FAM118B isoform X2

      Conserved Domains (1) summary
      pfam13289
      Location:158 → 301
      SIR2_2; SIR2-like domain

    5. XM_011242382.4 → XP_011240684.1  protein FAM118B isoform X1

      See identical proteins and their annotated locations for XP_011240684.1

      UniProtKB/Swiss-Prot
      Q3THR7, Q8BNN4, Q8BT26, Q8C569
      Conserved Domains (1) summary
      pfam13289
      Location:158 → 301
      SIR2_2; SIR2-like domain

    6. XM_036154556.1 → XP_036010449.1  protein FAM118B isoform X1

      UniProtKB/Swiss-Prot
      Q3THR7, Q8BNN4, Q8BT26, Q8C569
      Conserved Domains (1) summary
      pfam13289
      Location:158 → 301
      SIR2_2; SIR2-like domain

    7. XM_006509937.5 → XP_006510000.1  protein FAM118B isoform X1

      See identical proteins and their annotated locations for XP_006510000.1

      UniProtKB/Swiss-Prot
      Q3THR7, Q8BNN4, Q8BT26, Q8C569
      Conserved Domains (1) summary
      pfam13289
      Location:158 → 301
      SIR2_2; SIR2-like domain

    8. XM_030244006.2 → XP_030099866.1  protein FAM118B isoform X5

      Conserved Domains (1) summary
      pfam13289
      Location:21 → 164
      SIR2_2; SIR2-like domain

    9. XM_006509940.5 → XP_006510003.1  protein FAM118B isoform X4

      Conserved Domains (1) summary
      pfam13289
      Location:21 → 164
      SIR2_2; SIR2-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C569.1 GenPept UniProtKB/Swiss-Prot:Q8C569

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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