U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Mlec malectin [ Mus musculus (house mouse) ]

    Gene ID: 109154, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Mlecprovided by MGI
    Official Full Name
    malectinprovided by MGI
    Primary source
    MGI:MGI:1924015
    See related
    Ensembl:ENSMUSG00000048578 AllianceGenome:MGI:1924015
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM19; mKIAA0152; 2410014A08Rik
    Summary
    Predicted to enable enzyme binding activity. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in clavicle; craniocervical region bone; inner ear; lung; and submandibular gland primordium. Orthologous to human MLEC (malectin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 84.5), large intestine adult (RPKM 68.0) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    5 F; 5 55.99 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115281040..115296235, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115142981..115158176, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A dehydrogenase, short chain Neighboring gene unc-119 lipid binding chaperone B Neighboring gene STARR-positive B cell enhancer ABC_E10342 Neighboring gene STARR-seq mESC enhancer starr_14100 Neighboring gene STARR-positive B cell enhancer ABC_E1058 Neighboring gene STARR-seq mESC enhancer starr_14105 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:115617496-115617679 Neighboring gene calcium binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_14108 Neighboring gene STARR-seq mESC enhancer starr_14109 Neighboring gene predicted gene, 35515 Neighboring gene STARR-seq mESC enhancer starr_14111 Neighboring gene STARR-positive B cell enhancer ABC_E8072 Neighboring gene processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Ryder E, et al. Mamm Genome, 2013 Aug. PMID 23912999, Free PMC Article
    2. Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Ramírez AS, et al. Science, 2019 Dec 13. PMID 31831667
    3. Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering. Tchernev VT, et al. Genomics, 1997 Feb 15. PMID 9070936
    4. Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Bettenhausen B, et al. Genomics, 1995 Aug 10. PMID 7490078
    5. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC32493

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    malectin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175403.3 → NP_780612.2  malectin precursor

      See identical proteins and their annotated locations for NP_780612.2

      Status: VALIDATED

      Source sequence(s)
      AK031525, AK129066, BU703535, CJ093242, DV061883
      Consensus CDS
      CCDS19581.1
      UniProtKB/Swiss-Prot
      Q6ZQI3, Q8C6C3, Q8CD40, Q8CI91
      Related
      ENSMUSP00000107749.3, ENSMUST00000112121.6
      Conserved Domains (1) summary
      pfam11721
      Location:47 → 207
      Malectin; Di-glucose binding within endoplasmic reticulum

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115281040..115296235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164725.1 → XP_036020618.1  malectin isoform X1

      Conserved Domains (1) summary
      pfam11721
      Location:10 → 125
      Malectin; Di-glucose binding within endoplasmic reticulum

    2. XM_036164726.1 → XP_036020619.1  malectin isoform X1

      Conserved Domains (1) summary
      pfam11721
      Location:10 → 125
      Malectin; Di-glucose binding within endoplasmic reticulum
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQI3.2 GenPept UniProtKB/Swiss-Prot:Q6ZQI3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous