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    Supt3 SPT3, SAGA and STAGA complex component [ Mus musculus (house mouse) ]

    Gene ID: 109115, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Supt3provided by MGI
    Official Full Name
    SPT3, SAGA and STAGA complex componentprovided by MGI
    Primary source
    MGI:MGI:1923723
    See related
    Ensembl:ENSMUSG00000038954 AllianceGenome:MGI:1923723
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPT3; SPT3L; Supt3h; 2310066G22Rik
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in histone H3 acetylation and histone deubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of SAGA complex and transcription factor TFTC complex. Is expressed in bladder; ovary; testis; urethra of female; and urethra of male. Orthologous to human SUPT3H (SPT3 homolog, SAGA and STAGA complex component). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 2.7), CNS E11.5 (RPKM 1.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Supt3 in Genome Data Viewer
    Location:
    17 B3; 17 21.56 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45088005..45430181)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (44777118..45119294)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene chloride intracellular channel 5 Neighboring gene STARR-seq mESC enhancer starr_42608 Neighboring gene STARR-positive B cell enhancer ABC_E5611 Neighboring gene STARR-seq mESC enhancer starr_42609 Neighboring gene STARR-seq mESC enhancer starr_42610 Neighboring gene STARR-seq mESC enhancer starr_42611 Neighboring gene STARR-seq mESC enhancer starr_42612 Neighboring gene runt related transcription factor 2 Neighboring gene STARR-seq mESC enhancer starr_42613 Neighboring gene VISTA enhancer mm924 Neighboring gene runt related transcription factor 2, opposite strand 3 Neighboring gene STARR-seq mESC enhancer starr_42614 Neighboring gene VISTA enhancer mm657 Neighboring gene Runx2 P2 promoter Neighboring gene Runx2 P1 promoter region Neighboring gene RIKEN cDNA 4930564C03 gene Neighboring gene predicted gene, 52304 Neighboring gene STARR-seq mESC enhancer starr_42615 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45256870-45256979 Neighboring gene STARR-seq mESC enhancer starr_42616 Neighboring gene predicted gene, 35097 Neighboring gene coiled-coil domain containing 94 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status. Zelin E, et al. Mol Cell, 2012 Nov 9. PMID 23022381, Free PMC Article
    2. Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Nagy Z, et al. Oncogene, 2007 Aug 13. PMID 17694077
    3. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates. Schiltz RL, et al. J Biol Chem, 1999 Jan 15. PMID 9880483
    4. Histone-like TAFs within the PCAF histone acetylase complex. Ogryzko VV, et al. Cell, 1998 Jul 10. PMID 9674425
    5. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. Brand M, et al. EMBO J, 2001 Jun 15. PMID 11406595, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription initiation protein SPT3 homolog
    Names
    suppressor of Ty 3 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178652.3 → NP_848767.1  transcription initiation protein SPT3 homolog

      See identical proteins and their annotated locations for NP_848767.1

      Status: VALIDATED

      Source sequence(s)
      AK075916, AL672242, CX210559
      Consensus CDS
      CCDS37625.1
      UniProtKB/TrEMBL
      Q8BU36, Q8BVY4, Q8BWQ2
      Related
      ENSMUSP00000050783.8, ENSMUST00000050630.14
      Conserved Domains (2) summary
      pfam02269
      Location:24 → 116
      TFIID-18kDa; Transcription initiation factor IID, 18kD subunit
      cl02176
      Location:332 → 351
      TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    RNA

    1. NR_158206.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK075916, AL672242, BG067596, CX210559
      Related
      ENSMUST00000127798.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      45088005..45430181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523477.3 → XP_006523540.1  transcription initiation protein SPT3 homolog isoform X2

      See identical proteins and their annotated locations for XP_006523540.1

      UniProtKB/TrEMBL
      B0QZW4
      Conserved Domains (1) summary
      pfam02269
      Location:24 → 116
      TFIID-18kDa; Transcription initiation factor IID, 18kD subunit

    2. XM_030249446.1 → XP_030105306.1  transcription initiation protein SPT3 homolog isoform X4

      UniProtKB/TrEMBL
      B0QZW4
      Conserved Domains (2) summary
      cl02174
      Location:1 → 30
      TAF13; The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl02176
      Location:246 → 265
      TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    3. XM_030249447.1 → XP_030105307.1  transcription initiation protein SPT3 homolog isoform X3

      Conserved Domains (2) summary
      cl02174
      Location:1 → 30
      TAF13; The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl02176
      Location:246 → 265
      TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    4. XM_006523478.5 → XP_006523541.1  transcription initiation protein SPT3 homolog isoform X2

      See identical proteins and their annotated locations for XP_006523541.1

      UniProtKB/TrEMBL
      B0QZW4
      Related
      ENSMUSP00000120197.2, ENSMUST00000129416.2
      Conserved Domains (1) summary
      pfam02269
      Location:24 → 116
      TFIID-18kDa; Transcription initiation factor IID, 18kD subunit

    5. XM_006523479.5 → XP_006523542.2  transcription initiation protein SPT3 homolog isoform X3

      Conserved Domains (2) summary
      cl02174
      Location:1 → 30
      TAF13; The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl02176
      Location:246 → 265
      TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    6. XM_030249445.1 → XP_030105305.1  transcription initiation protein SPT3 homolog isoform X1

      Conserved Domains (1) summary
      cl02174
      Location:1 → 30
      TAF13; The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001357320.1: Suppressed sequence

      Description
      NM_001357320.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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