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    Slc30a9 solute carrier family 30 (zinc transporter), member 9 [ Mus musculus (house mouse) ]

    Gene ID: 109108, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Slc30a9provided by MGI
    Official Full Name
    solute carrier family 30 (zinc transporter), member 9provided by MGI
    Primary source
    MGI:MGI:1923690
    See related
    Ensembl:ENSMUSG00000029221 AllianceGenome:MGI:1923690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HUEL; GAC63; znT-9; 2310024J23Rik
    Summary
    Enables chromatin binding activity; nuclear receptor binding activity; and nuclear receptor coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasmic vesicle; cytoskeleton; and endoplasmic reticulum. Predicted to be active in nucleus. Is expressed in cranial ganglion and urethra. Orthologous to human SLC30A9 (solute carrier family 30 member 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 23.5), frontal lobe adult (RPKM 21.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 C3.1; 5 36.02 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (67464298..67513485)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (67306955..67356142)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40314 Neighboring gene STARR-positive B cell enhancer ABC_E3579 Neighboring gene STARR-seq mESC enhancer starr_13313 Neighboring gene transmembrane protein 33 Neighboring gene CRISPRi-validated cis-regulatory element for Bend4 and Slc30a9 Neighboring gene STARR-seq mESC enhancer starr_13315 Neighboring gene STARR-seq mESC enhancer starr_13316 Neighboring gene BEN domain containing 4 Neighboring gene predicted gene, 33345 Neighboring gene predicted gene 42632

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of GAC63 in transcriptional activation mediated by the aryl hydrocarbon receptor. Chen YH, et al. J Biol Chem, 2006 May 5. PMID 16513642, Free PMC Article
    2. The novel human HUEL (C4orf1) protein shares homology with the DNA-binding domain of the XPA DNA repair protein and displays nuclear translocation in a cell cycle-dependent manner. Sim DL, et al. Int J Biochem Cell Biol, 2002 May. PMID 11906820
    3. GAC63, a GRIP1-dependent nuclear receptor coactivator. Chen YH, et al. Mol Cell Biol, 2005 Jul. PMID 15988012, Free PMC Article
    4. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Forrest MP, et al. Nat Commun, 2023 Feb 17. PMID 36808153, Free PMC Article
    5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (5) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proton-coupled zinc antiporter SLC30A9, mitochondrial
    Names
    GRIP1-associated coactivator 1
    GRIP1-associated coactivator 63
    zinc transporter 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310629.1 → NP_001297558.1  proton-coupled zinc antiporter SLC30A9, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK038559, AK082853, BY237302, CX568220
      Consensus CDS
      CCDS80294.1
      UniProtKB/TrEMBL
      B2RU82, F8WHL1
      Related
      ENSMUSP00000109306.3, ENSMUST00000113676.6
      Conserved Domains (3) summary
      TIGR00598
      Location:103 → 188
      rad14; DNA repair protein
      pfam01545
      Location:230 → 429
      Cation_efflux; Cation efflux family
      pfam12137
      Location:489 → 547
      RapA_C; RNA polymerase recycling family C-terminal

    2. NM_178651.4 → NP_848766.2  proton-coupled zinc antiporter SLC30A9, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_848766.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK035541, AK082853, BY237302
      Consensus CDS
      CCDS39103.1
      UniProtKB/Swiss-Prot
      Q5IRJ6, Q66L46, Q7TNE9, Q8BGX8, Q8BUR1, Q8BZP2, Q8K2E0, Q8K376, Q8R0P1, Q9JK46
      UniProtKB/TrEMBL
      B2RU82
      Related
      ENSMUSP00000124047.2, ENSMUST00000162372.8
      Conserved Domains (3) summary
      TIGR00598
      Location:123 → 208
      rad14; DNA repair protein
      pfam01545
      Location:250 → 449
      Cation_efflux; Cation efflux family
      pfam12137
      Location:509 → 567
      RapA_C; RNA polymerase recycling family C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      67464298..67513485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5IRJ6.2 GenPept UniProtKB/Swiss-Prot:Q5IRJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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