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    Rars2 arginyl-tRNA synthetase 2, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 109093, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rars2provided by MGI
    Official Full Name
    arginyl-tRNA synthetase 2, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1923596
    See related
    Ensembl:ENSMUSG00000028292 AllianceGenome:MGI:1923596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rarsl; PRO1992; 1500002I10Rik
    Summary
    Predicted to enable arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation and mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; hemolymphoid system; nervous system; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.5), placenta adult (RPKM 7.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 A5; 4 16.84 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34614941..34660167)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34614957..34660167)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09910 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:34497692-34497879 Neighboring gene akirin 2 Neighboring gene STARR-seq mESC enhancer starr_09912 Neighboring gene origin recognition complex, subunit 3 Neighboring gene solute carrier family 35 (CMP-sialic acid transporter), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E6160 Neighboring gene cilia and flagella associated protein 206 Neighboring gene STARR-seq mESC enhancer starr_09914

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable arginine--tRNA ligase, mitochondrial
    Names
    argRS
    arginine--tRNA ligase
    arginyl-tRNA synthetase 2, mitochondrial (putative)
    probable arginyl-tRNA synthetase, mitochondrial
    NP_852071.2
    XP_011248204.1
    XP_017175401.1
    XP_030108934.1
    XP_030108935.1
    XP_030108936.1
    XP_036019465.1
    XP_036019466.1
    XP_036019467.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181406.4 → NP_852071.2  probable arginine--tRNA ligase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_852071.2

      Status: VALIDATED

      Source sequence(s)
      AK075721, AK166986, AL928738, AW120679
      Consensus CDS
      CCDS18029.1
      UniProtKB/Swiss-Prot
      Q3U186, Q8QZU7
      Related
      ENSMUSP00000029968.8, ENSMUST00000029968.14
      Conserved Domains (3) summary
      cd00671
      Location:126 → 388
      ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
      COG0018
      Location:30 → 578
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cl12020
      Location:425 → 578
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    RNA

    1. NR_151507.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK075721, AK166986, AL928738, AW120679

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      34614941..34660167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163573.1 → XP_036019466.1  probable arginine--tRNA ligase, mitochondrial isoform X2

      Conserved Domains (1) summary
      COG0018
      Location:9 → 550
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    2. XM_030253074.2 → XP_030108934.1  probable arginine--tRNA ligase, mitochondrial isoform X4

      Conserved Domains (1) summary
      COG0018
      Location:2 → 403
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    3. XM_011249902.3 → XP_011248204.1  probable arginine--tRNA ligase, mitochondrial isoform X3

      Conserved Domains (1) summary
      COG0018
      Location:49 → 423
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    4. XM_017319912.3 → XP_017175401.1  probable arginine--tRNA ligase, mitochondrial isoform X3

      Conserved Domains (1) summary
      COG0018
      Location:49 → 423
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    5. XM_030253075.2 → XP_030108935.1  probable arginine--tRNA ligase, mitochondrial isoform X5

      Conserved Domains (1) summary
      COG0018
      Location:9 → 347
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    6. XM_030253076.2 → XP_030108936.1  probable arginine--tRNA ligase, mitochondrial isoform X5

      Conserved Domains (1) summary
      COG0018
      Location:9 → 347
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    7. XM_036163574.1 → XP_036019467.1  probable arginine--tRNA ligase, mitochondrial isoform X5

      Conserved Domains (1) summary
      COG0018
      Location:9 → 347
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    8. XM_036163572.1 → XP_036019465.1  probable arginine--tRNA ligase, mitochondrial isoform X1

      Conserved Domains (1) summary
      COG0018
      Location:20 → 568
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U186.1 GenPept UniProtKB/Swiss-Prot:Q3U186

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