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    Pfdn4 prefoldin 4 [ Mus musculus (house mouse) ]

    Gene ID: 109054, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pfdn4provided by MGI
    Official Full Name
    prefoldin 4provided by MGI
    Primary source
    MGI:MGI:1923512
    See related
    Ensembl:ENSMUSG00000052033 AllianceGenome:MGI:1923512
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C1; C-1; Pfd4; 0610025M10Rik; 1810063B06Rik
    Summary
    Predicted to enable amyloid-beta binding activity and unfolded protein binding activity. Predicted to be involved in negative regulation of amyloid fibril formation and protein folding. Predicted to be located in mitochondrion and nucleus. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN4 (prefoldin subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 16.3), CNS E18 (RPKM 14.7) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H3; 2 91.91 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (170338348..170360987)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (170496428..170519070)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06529 Neighboring gene predicted gene, 34608 Neighboring gene predicted gene, 40000 Neighboring gene cytochrome P450, family 24, subfamily a, polypeptide 1 Neighboring gene STARR-positive B cell enhancer ABC_E9211 Neighboring gene predicted gene, 16796 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:170334342-170334495 Neighboring gene STARR-positive B cell enhancer ABC_E822 Neighboring gene STARR-seq mESC enhancer starr_06531 Neighboring gene STARR-seq mESC enhancer starr_06532 Neighboring gene predicted gene, 40001 Neighboring gene RIKEN cDNA 4930470P17 gene Neighboring gene predicted gene 14637

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Ewart-Toland A, et al. Nat Genet, 2003 Aug. PMID 12881723
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of prefoldin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prefoldin subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013369.3 → NP_001013387.1  prefoldin subunit 4 isoform 2

      See identical proteins and their annotated locations for NP_001013387.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 2. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AL935134, AL954701
      Consensus CDS
      CCDS50808.1
      UniProtKB/TrEMBL
      Q6P0X1
      Related
      ENSMUSP00000074596.2, ENSMUST00000075087.8
      Conserved Domains (1) summary
      pfam01920
      Location:1 → 67
      Prefoldin_2; Prefoldin subunit

    2. NM_001110152.3 → NP_001103622.1  prefoldin subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_001103622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL954701
      Consensus CDS
      CCDS50807.1
      UniProtKB/TrEMBL
      Q3UWL8
      Related
      ENSMUSP00000070596.6, ENSMUST00000063682.12
      Conserved Domains (1) summary
      pfam01920
      Location:23 → 125
      Prefoldin_2; Prefoldin subunit

    3. NM_001199902.2 → NP_001186831.1  prefoldin subunit 4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AL954701
      Consensus CDS
      CCDS57190.1
      UniProtKB/TrEMBL
      E9Q6U4
      Related
      ENSMUSP00000130383.2, ENSMUST00000136839.2
      Conserved Domains (1) summary
      pfam01920
      Location:20 → 120
      Prefoldin_2; Prefoldin subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      170338348..170360987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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