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    Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 [ Mus musculus (house mouse) ]

    Gene ID: 108760, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Galnt16provided by MGI
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 16provided by MGI
    Primary source
    MGI:MGI:1917754
    See related
    Ensembl:ENSMUSG00000021130 AllianceGenome:MGI:1917754
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Galntl1; galNAc-T16; 5730405L21Rik; mpp-GalNAc-T16
    Summary
    Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in embryo mesenchyme; limb; and nervous system. Orthologous to human GALNT16 (polypeptide N-acetylgalactosaminyltransferase 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 9.5), cerebellum adult (RPKM 7.3) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 C3; 12 36.79 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (80565245..80650672)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (80518471..80603898)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46363 Neighboring gene STARR-seq mESC enhancer starr_32637 Neighboring gene STARR-seq mESC enhancer starr_32638 Neighboring gene exonuclease 3'-5' domain containing 2 Neighboring gene RIKEN cDNA 2310002D06 gene Neighboring gene predicted gene, 26777 Neighboring gene STARR-seq mESC enhancer starr_32641 Neighboring gene STARR-seq mESC enhancer starr_32643 Neighboring gene predicted gene, 46364 Neighboring gene predicted gene, 23817

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
    2. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
    3. Galnt1 is required for normal heart valve development and cardiac function. Tian E, et al. PLoS One, 2015. PMID 25615642, Free PMC Article
    4. O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components. Tian E, et al. Nat Commun, 2012 May 29. PMID 22643896, Free PMC Article
    5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation via serine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation via threonine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 16
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1
    galNAc-T-like protein 1
    polypeptide GalNAc transferase 16
    polypeptide GalNAc transferase-like protein 1
    pp-GaNTase-like protein 1
    protein-UDP acetylgalactosaminyltransferase-like protein 1
    putative polypeptide N-acetylgalactosaminyltransferase-like protein 1
    NP_001074890.1
    NP_001348629.1
    NP_001348630.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081421.2 → NP_001074890.1  polypeptide N-acetylgalactosaminyltransferase 16

      See identical proteins and their annotated locations for NP_001074890.1

      Status: VALIDATED

      Source sequence(s)
      AC125361, AC163282
      Consensus CDS
      CCDS36482.1
      UniProtKB/Swiss-Prot
      Q60GT0, Q9JJ61
      UniProtKB/TrEMBL
      Q69ZR3
      Related
      ENSMUSP00000021558.7, ENSMUST00000021558.8
      Conserved Domains (2) summary
      cd02510
      Location:126 → 420
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:441 → 552
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. NM_001361700.1 → NP_001348629.1  polypeptide N-acetylgalactosaminyltransferase 16

      Status: VALIDATED

      Source sequence(s)
      AC125361, AC163282
      Consensus CDS
      CCDS36482.1
      UniProtKB/Swiss-Prot
      Q60GT0, Q9JJ61
      UniProtKB/TrEMBL
      Q69ZR3
      Related
      ENSMUSP00000151829.2, ENSMUST00000219993.2
      Conserved Domains (2) summary
      cd02510
      Location:126 → 420
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:441 → 552
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    3. NM_001361701.1 → NP_001348630.1  polypeptide N-acetylgalactosaminyltransferase 16

      Status: VALIDATED

      Source sequence(s)
      AC125361, AC163282
      Consensus CDS
      CCDS36482.1
      UniProtKB/Swiss-Prot
      Q60GT0, Q9JJ61
      UniProtKB/TrEMBL
      Q69ZR3
      Related
      ENSMUSP00000151619.2, ENSMUST00000218943.2
      Conserved Domains (2) summary
      cd02510
      Location:126 → 420
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:441 → 552
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      80565245..80650672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_134045.1: Suppressed sequence

      Description
      NM_134045.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJ61.2 GenPept UniProtKB/Swiss-Prot:Q9JJ61

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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