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    Zdhhc15 zinc finger, DHHC domain containing 15 [ Mus musculus (house mouse) ]

    Gene ID: 108672, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Zdhhc15provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 15provided by MGI
    Primary source
    MGI:MGI:1915336
    See related
    Ensembl:ENSMUSG00000033906 AllianceGenome:MGI:1915336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030457O13Rik
    Summary
    Enables protein-cysteine S-palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Acts upstream of or within establishment of protein localization; protein palmitoylation; and synaptic vesicle maturation. Located in Golgi apparatus. Is expressed in eye. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 91. Orthologous to human ZDHHC15 (zinc finger DHHC-type palmitoyltransferase 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 3.1), CNS E11.5 (RPKM 2.2) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X D; X 46.69 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (103580575..103714696, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (104536969..104671090, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene uracil phosphoribosyltransferase Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47713 Neighboring gene STARR-seq mESC enhancer starr_47714 Neighboring gene predicted gene, 22430 Neighboring gene STARR-seq mESC enhancer starr_47715 Neighboring gene predicted gene, 39530 Neighboring gene STARR-seq mESC enhancer starr_47716 Neighboring gene STARR-seq mESC enhancer starr_47717 Neighboring gene STARR-seq mESC enhancer starr_47718 Neighboring gene RIKEN cDNA 1700121L16 gene Neighboring gene MAGE family member E2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry. Greaves J, et al. Proc Natl Acad Sci U S A, 2017 Feb 21. PMID 28167757, Free PMC Article
    2. Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. Greaves J, et al. J Biol Chem, 2008 Sep 5. PMID 18596047, Free PMC Article
    3. SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Blewitt ME, et al. Nat Genet, 2008 May. PMID 18425126
    4. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741
    5. Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Gendrel AV, et al. Mol Cell Biol, 2013 Aug. PMID 23754746, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-myristoyltransferase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-stearoyltransferase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within synaptic vesicle maturation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within synaptic vesicle maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC15
    Names
    DHHC-15
    acyltransferase ZDHHC15
    zinc finger DHHC domain-containing protein 15
    NP_780567.1
    XP_011245807.1
    XP_011245808.1
    XP_017173831.1
    XP_036017665.1
    XP_036017666.1
    XP_036017667.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175358.4 → NP_780567.1  palmitoyltransferase ZDHHC15

      See identical proteins and their annotated locations for NP_780567.1

      Status: VALIDATED

      Source sequence(s)
      AK077949, AK132304, AL731717, BY652237
      Consensus CDS
      CCDS30332.1
      UniProtKB/Swiss-Prot
      Q3TV63, Q8BGJ0, Q8BMB7
      Related
      ENSMUSP00000047615.6, ENSMUST00000042070.6
      Conserved Domains (1) summary
      cl19890
      Location:126 → 308
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      103580575..103714696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247506.1 → XP_011245808.1  palmitoyltransferase ZDHHC15 isoform X2

      Conserved Domains (1) summary
      cl19890
      Location:126 → 308
      DHHC; DHHC palmitoyltransferase

    2. XM_011247505.1 → XP_011245807.1  palmitoyltransferase ZDHHC15 isoform X1

      Conserved Domains (1) summary
      cl19890
      Location:126 → 308
      DHHC; DHHC palmitoyltransferase

    3. XM_036161774.1 → XP_036017667.1  palmitoyltransferase ZDHHC15 isoform X6

      Conserved Domains (1) summary
      cl19890
      Location:20 → 199
      DHHC; DHHC palmitoyltransferase

    4. XM_017318342.3 → XP_017173831.1  palmitoyltransferase ZDHHC15 isoform X5

      Conserved Domains (1) summary
      cl19890
      Location:20 → 199
      DHHC; DHHC palmitoyltransferase

    5. XM_036161773.1 → XP_036017666.1  palmitoyltransferase ZDHHC15 isoform X4

      Conserved Domains (1) summary
      cl19890
      Location:126 → 308
      DHHC; DHHC palmitoyltransferase

    6. XM_036161772.1 → XP_036017665.1  palmitoyltransferase ZDHHC15 isoform X3

      Conserved Domains (1) summary
      cl19890
      Location:126 → 308
      DHHC; DHHC palmitoyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGJ0.1 GenPept UniProtKB/Swiss-Prot:Q8BGJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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