Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Olr1provided by MGI
Official Full Name: oxidized low density lipoprotein (lectin-like) receptor 1provided by MGI
Primary source: MGI:MGI:1261434
See related: Ensembl:ENSMUSG00000030162 AllianceGenome:MGI:1261434
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LOX-1; SR-EI; Scare1
Summary: Enables low-density lipoprotein particle receptor activity. Predicted to be involved in several processes, including inflammatory response; leukocyte cell-cell adhesion; and lipoprotein metabolic process. Predicted to act upstream of or within cell adhesion and immune system process. Predicted to be located in nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in blood vessel; embryo; heart; and primitive ventricle. Human ortholog(s) of this gene implicated in cerebral amyloid angiopathy; coronary artery disease; and myocardial infarction. Orthologous to human OLR1 (oxidized low density lipoprotein receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 10.0), lung adult (RPKM 1.0) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 63.35 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129456113..129484312, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129479150..129507350, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of LOX-1 ameliorates bone quality and generation of type H blood vessels in diabetic mice.
Title: Knockdown of LOX-1 ameliorates bone quality and generation of type H blood vessels in diabetic mice.
LOX-1 acts as an N[6]-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase.
Title: LOX-1 acts as an N(6)-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase.
Macrophage KLF15 prevents foam cell formation and atherosclerosis via transcriptional suppression of OLR-1.
Title: Macrophage KLF15 prevents foam cell formation and atherosclerosis via transcriptional suppression of OLR-1.
Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15.
Title: Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15.
Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury.
Title: Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury.
Nrf2 deficiency attenuates atherosclerosis by reducing LOX-1-mediated proliferation and migration of vascular smooth muscle cells.
Title: Nrf2 deficiency attenuates atherosclerosis by reducing LOX-1-mediated proliferation and migration of vascular smooth muscle cells.
Niclosamide downregulates LOX-1 expression in mouse vascular smooth muscle cells and changes the composition of atherosclerotic plaques in ApoE(-/-) mice.
Title: Niclosamide downregulates LOX-1 expression in mouse vascular smooth muscle cells and changes the composition of atherosclerotic plaques in ApoE(-/-) mice.
LOX-1 Regulates Neutrophil Apoptosis and Fungal Load in A. Fumigatus Keratitis.
Title: LOX-1 Regulates Neutrophil Apoptosis and Fungal Load in A. Fumigatus Keratitis.
Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model.
Title: Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model.
Oxidized low-density lipoprotein stimulates dendritic cells maturation via LOX-1-mediated MAPK/NF-kappaB pathway.
Title: Oxidized low-density lipoprotein stimulates dendritic cells maturation via LOX-1-mediated MAPK/NF-κB pathway.

Submit: New GeneRIF Correction See all GeneRIFs (89)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5)

General gene information

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Markers

Olr1 (e-PCR), detects polymorphism
- UniSTS:547554

Olr1 (e-PCR), detects polymorphism
- UniSTS:547555

Olr1 (e-PCR), detects polymorphism
- UniSTS:547556

NoName (e-PCR)
- UniSTS:490746

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extrinsic component of plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: oxidized low-density lipoprotein receptor 1

Names: lectin-like oxLDL receptor 1; lectin-like oxidized LDL receptor 1; lectin-type oxidized LDL receptor 1; ox-LDL receptor 1; oxidised low density lipoprotein (lectin-like) receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301094.1 → NP_001288023.1 oxidized low-density lipoprotein receptor 1 isoform 3

See identical proteins and their annotated locations for NP_001288023.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.

Source sequence(s)

AC161602, BX513847

Consensus CDS

CCDS80620.1

UniProtKB/TrEMBL

G4WK10

Related

ENSMUSP00000138588.2, ENSMUST00000182784.4

Conserved Domains (1) summary

cd03593
Location:61 → 182

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_001301096.1 → NP_001288025.1 oxidized low-density lipoprotein receptor 1 isoform 2

See identical proteins and their annotated locations for NP_001288025.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC161602, BX513847

Consensus CDS

CCDS80619.1

UniProtKB/TrEMBL

G4WK09

Related

ENSMUSP00000138228.2, ENSMUST00000183258.8

Conserved Domains (1) summary

cd03593
Location:27 → 148

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_138648.2 → NP_619589.2 oxidized low-density lipoprotein receptor 1 isoform 1

See identical proteins and their annotated locations for NP_619589.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK160919, BX513847

Consensus CDS

CCDS20588.1

UniProtKB/Swiss-Prot

Q3U3M1, Q9EQ09

Related

ENSMUSP00000032265.7, ENSMUST00000032265.13

Conserved Domains (4) summary

cd03593
Location:235 → 356

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam01442
Location:71 → 229

Apolipoprotein; Apolipoprotein A1/A4/E domain

pfam06273
Location:156 → 214

eIF-4B; Plant specific eukaryotic initiation factor 4B

cl12057
Location:96 → 175

Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

129456113..129484312 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321299.3 → XP_017176788.1 oxidized low-density lipoprotein receptor 1 isoform X1

Conserved Domains (2) summary

cd03593
Location:189 → 310

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

TIGR02168
Location:58 → 184

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_017321300.1 → XP_017176789.1 oxidized low-density lipoprotein receptor 1 isoform X2

Conserved Domains (2) summary

cd03593
Location:152 → 273

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

TIGR02168
Location:3 → 147

SMC_prok_B; chromosome segregation protein SMC, common bacterial type