Grm3 glutamate receptor, metabotropic 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grm3provided by MGI
Official Full Name: glutamate receptor, metabotropic 3provided by MGI
Primary source: MGI:MGI:1351340
See related: Ensembl:ENSMUSG00000003974 AllianceGenome:MGI:1351340
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mGlu3; Gprc1c; mGluR3; 0710001G23Rik
Summary: Enables calcium channel regulator activity and group II metabotropic glutamate receptor activity. Acts upstream of or within gene expression. Located in several cellular components, including glutamatergic synapse; postsynaptic density; and synaptic membrane. Is integral component of postsynaptic membrane. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and visual system. Orthologous to human GRM3 (glutamate metabotropic receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 11.5), frontal lobe adult (RPKM 9.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A1; 5 3.69 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (9535235..9776087, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (9485236..9725352, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A metabotropic glutamate receptor 3 (mGlu3R) isoform playing neurodegenerative roles in astrocytes is prematurely up-regulated in an Alzheimer's model.
Title: A metabotropic glutamate receptor 3 (mGlu3R) isoform playing neurodegenerative roles in astrocytes is prematurely up-regulated in an Alzheimer's model.
Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.
Title: Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.
Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.
Title: Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.
mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.
Title: mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.
Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu3) impairs postsynaptic plasticity and modulates affective behaviors.
Title: Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu(3)) impairs postsynaptic plasticity and modulates affective behaviors.
Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.
Title: Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.
mGlu3 receptor regulates microglial cell reactivity in neonatal rats.
Title: mGlu3 receptor regulates microglial cell reactivity in neonatal rats.
Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus.
Title: Activating mGlu(3) Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus.
The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.
Title: The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.
hese findings suggest that mGlu3 receptors have a strong impact on the development of cortical GABAergic transmission and cortical neural synchronization mechanisms corroborating the concept that genetic variants of mGlu3 receptors may predispose to psychiatric disorders.
Title: Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-18027 (e-PCR)
- UniSTS:15935

Grm3 (e-PCR), detects polymorphism
- UniSTS:506954

Grm3 (e-PCR), detects polymorphism
- UniSTS:495991

42.MMHAP25FLF6.seq (e-PCR)
- UniSTS:207749

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables group II metabotropic glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables group II metabotropic glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables group II metabotropic glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of sensory perception of pain	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	NAS Non-traceable Author Statement more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: metabotropic glutamate receptor 3

Names: G protein-coupled receptor, family C, group 1, member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417964.1 → NP_001404893.1 metabotropic glutamate receptor 3 precursor

Status: VALIDATED

Source sequence(s)

AC157555, AC162520

UniProtKB/Swiss-Prot

Q14DJ9, Q9QYS2
NM_181850.3 → NP_862898.1 metabotropic glutamate receptor 3 precursor

See identical proteins and their annotated locations for NP_862898.1

Status: VALIDATED

Source sequence(s)

AC157555, AC162520

Consensus CDS

CCDS19090.1

UniProtKB/Swiss-Prot

Q14DJ9, Q9QYS2

Related

ENSMUSP00000004076.4, ENSMUST00000004076.5

Conserved Domains (3) summary

cd15448
Location:575 → 828

7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06375
Location:33 → 494

PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

pfam07562
Location:505 → 555

NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

9535235..9776087 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164718.1 → XP_036020611.1 metabotropic glutamate receptor 3 isoform X1

UniProtKB/Swiss-Prot

Q14DJ9, Q9QYS2

Conserved Domains (3) summary

cd15448
Location:575 → 828

7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06375
Location:33 → 494

PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

pfam07562
Location:505 → 555

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_036164719.1 → XP_036020612.1 metabotropic glutamate receptor 3 isoform X1

UniProtKB/Swiss-Prot

Q14DJ9, Q9QYS2

Conserved Domains (3) summary

cd15448
Location:575 → 828

7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06375
Location:33 → 494

PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

pfam07562
Location:505 → 555

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_036164720.1 → XP_036020613.1 metabotropic glutamate receptor 3 isoform X1

UniProtKB/Swiss-Prot

Q14DJ9, Q9QYS2

Conserved Domains (3) summary

cd15448
Location:575 → 828

7tmC_mGluR3; metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06375
Location:33 → 494

PBP1_mGluR_groupII; ligand binding domain of the group II metabotropic glutamate receptor

pfam07562
Location:505 → 555

NCD3G; Nine Cysteines Domain of family 3 GPCR