Grm2 glutamate receptor, metabotropic 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grm2provided by MGI
Official Full Name: glutamate receptor, metabotropic 2provided by MGI
Primary source: MGI:MGI:1351339
See related: Ensembl:ENSMUSG00000023192 AllianceGenome:MGI:1351339
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gprc1b; mGluR2; mGluR7; 4930441L02Rik
Summary: Enables calcium channel regulator activity and group II metabotropic glutamate receptor activity. Acts upstream of or within chemical synaptic transmission; gene expression; and glutamate homeostasis. Located in neuron projection. Is expressed in brain. Orthologous to human GRM2 (glutamate metabotropic receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 23.0), cortex adult (RPKM 16.8) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 57.98 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (106521733..106533308, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (106644534..106656109, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRM2 Regulates Functional Integration of Adult-Born DGCs by Paradoxically Modulating MEK/ERK1/2 Pathway.
Title: GRM2 Regulates Functional Integration of Adult-Born DGCs by Paradoxically Modulating MEK/ERK1/2 Pathway.
Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.
Title: Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.
Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.
Title: Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.
mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.
Title: mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.
Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.
Title: Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.
The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.
Title: The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.
An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping.
Title: An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping.
Grm2(-/-) mice had a stress-resilient phenotype.
Title: Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.
Here we show that glutamate signals through metabotropic glutamate receptor 2 (mGluR2) to induce Erk phosphorylation in SC. mGluR2-elicited Erk phosphorylation requires ErbB2/3 receptor tyrosine kinase phosphorylation to limit the signaling cascade that promotes phosphorylation of Erk, but not Akt.
Title: Glutamate signals through mGluR2 to control Schwann cell differentiation and proliferation.
activation of mGlu2 receptors is detrimental in the post-ischemic phase, and support the use of mGlu2 receptor antagonists in the experimental treatment of brain ischemia.
Title: Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables group II metabotropic glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables group II metabotropic glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables group II metabotropic glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in behavioral response to nicotine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glutamate secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular glutamate homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of response to drug	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cocaine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: metabotropic glutamate receptor 2

Names: G protein-coupled receptor, family C, group 1, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001160353.1 → NP_001153825.1 metabotropic glutamate receptor 2 precursor

See identical proteins and their annotated locations for NP_001153825.1

Status: VALIDATED

Source sequence(s)

AC152452, BC115866, BQ174642, BY290719, CK619406

Consensus CDS

CCDS52914.1

UniProtKB/Swiss-Prot

Q14BI2

Related

ENSMUSP00000023959.8, ENSMUST00000023959.13

Conserved Domains (4) summary

cd06375
Location:30 → 480

PBP1_mGluR_groupII; Ligand binding domain of the group II metabotropic glutamate receptor

pfam00003
Location:579 → 816

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:60 → 456

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:498 → 545

NCD3G; Nine Cysteines Domain of family 3 GPCR