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    Eif2b3 eukaryotic translation initiation factor 2B, subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 108067, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Eif2b3provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2B, subunit 3provided by MGI
    Primary source
    MGI:MGI:1313286
    See related
    Ensembl:ENSMUSG00000028683 AllianceGenome:MGI:1313286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1190002P15Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to contribute to translation factor activity, RNA binding. Predicted to be involved in several processes, including T cell receptor signaling pathway; cytoplasmic translational initiation; and oligodendrocyte development. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Is expressed in central nervous system; gonad; retina; and thyroid gland. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 4.2), CNS E11.5 (RPKM 4.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D1; 4 53.41 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116876559..116944049)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117019399..117086852)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116691908-116692017 Neighboring gene tetraspanin 17 pseudogene Neighboring gene predicted gene, 22335 Neighboring gene STARR-seq mESC enhancer starr_11152 Neighboring gene Ptch2 Hedgehog-responsive enhancers Neighboring gene patched 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116793139-116793326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116797070-116797223 Neighboring gene BTB domain containing 19 Neighboring gene dynein light chain Tctex-type 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A molecular profile of a hematopoietic stem cell niche. Hackney JA, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12226475, Free PMC Article
    2. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to translation factor activity, RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of guanyl-nucleotide exchange factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    translation initiation factor eIF2B subunit gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111277.2 → NP_001104747.1  translation initiation factor eIF2B subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_001104747.1

      Status: VALIDATED

      Source sequence(s)
      AK145856, BC115657, BE952243, BQ828648, BY277686
      Consensus CDS
      CCDS51279.1
      UniProtKB/TrEMBL
      B1AUN2, B1AUN3
      Related
      ENSMUSP00000102056.3, ENSMUST00000106448.9
      Conserved Domains (3) summary
      cd04652
      Location:357 → 437
      LbH_eIF2B_gamma_C; eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...
      cd04198
      Location:3 → 212
      eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
      COG1208
      Location:4 → 447
      GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]

    2. NM_001355225.1 → NP_001342154.1  translation initiation factor eIF2B subunit gamma isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK145856, BE952243, BM945817, BQ176818, BQ828648, BY277686, DV041891
      Conserved Domains (1) summary
      cd04652
      Location:142 → 222
      LbH_eIF2B_gamma_C; eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...

    3. NM_175135.5 → NP_780344.2  translation initiation factor eIF2B subunit gamma isoform 2

      See identical proteins and their annotated locations for NP_780344.2

      Status: VALIDATED

      Source sequence(s)
      AK145856, AK165157, BQ828648, BY277686
      Consensus CDS
      CCDS18524.1
      UniProtKB/TrEMBL
      B1AUN3, Q3UKV0
      Related
      ENSMUSP00000102055.3, ENSMUST00000106447.9
      Conserved Domains (3) summary
      cd04198
      Location:3 → 212
      eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
      COG1208
      Location:4 → 399
      GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
      cl00160
      Location:357 → 401
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116876559..116944049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502649.3 → XP_006502712.1  translation initiation factor eIF2B subunit gamma isoform X1

      UniProtKB/TrEMBL
      B1AUN3
      Conserved Domains (2) summary
      cd04198
      Location:3 → 212
      eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
      cl00160
      Location:357 → 401
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    Nucleotide Protein Strain
    Heading Accession and Version

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