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    Gtpbp6 GTP binding protein 6 (putative) [ Mus musculus (house mouse) ]

    Gene ID: 107999, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gtpbp6provided by MGI
    Official Full Name
    GTP binding protein 6 (putative)provided by MGI
    Primary source
    MGI:MGI:1306825
    See related
    Ensembl:ENSMUSG00000033434 AllianceGenome:MGI:1306825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    pgpl; Pgbpll
    Summary
    Predicted to enable ribosome binding activity. Predicted to be active in cytoplasm. Orthologous to human GTPBP6 (GTP binding protein 6 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 45.4), thymus adult (RPKM 43.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 53.3 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110251842..110256063, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110103976..110108331, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13942 Neighboring gene predicted gene, 35315 Neighboring gene STARR-positive B cell enhancer ABC_E3596 Neighboring gene predicted gene, 54335 Neighboring gene STARR-positive B cell enhancer ABC_E4778 Neighboring gene STARR-positive B cell enhancer ABC_E10339 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3597 Neighboring gene zinc finger protein 605 Neighboring gene nucleophosmin pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6362 Neighboring gene STARR-seq mESC enhancer starr_13946 Neighboring gene checkpoint with forkhead and ring finger domains Neighboring gene predicted gene 15787

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution. Gianfrancesco F, et al. Genome Res, 2001 Dec. PMID 11731500, Free PMC Article
    2. A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere. Gianfrancesco F, et al. Hum Mol Genet, 1998 Mar. PMID 9466997
    3. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative GTP-binding protein 6
    Names
    pseudoautosomal GTP binding protein-like, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145147.5 → NP_660129.2  putative GTP-binding protein 6

      See identical proteins and their annotated locations for NP_660129.2

      Status: VALIDATED

      Source sequence(s)
      AK082192, AK152225
      Consensus CDS
      CCDS51604.1
      UniProtKB/Swiss-Prot
      Q3TX13, Q3U6U5, Q3UMM2
      UniProtKB/TrEMBL
      A0A0R4J0Z0
      Related
      ENSMUSP00000076458.8, ENSMUST00000077220.14
      Conserved Domains (3) summary
      cd01878
      Location:272 → 443
      HflX; HflX GTPase family
      COG2262
      Location:101 → 503
      HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]
      pfam13167
      Location:111 → 197
      GTP-bdg_N; GTP-binding GTPase N-terminal

    RNA

    1. NR_189623.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166747

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110251842..110256063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254041.2 → XP_030109901.1  putative GTP-binding protein 6 isoform X4

      UniProtKB/TrEMBL
      Q8K372
      Conserved Domains (1) summary
      cd01878
      Location:65 → 236
      HflX; HflX GTPase family

    2. XM_036164716.1 → XP_036020609.1  putative GTP-binding protein 6 isoform X4

      UniProtKB/TrEMBL
      Q8K372
      Conserved Domains (1) summary
      cd01878
      Location:65 → 236
      HflX; HflX GTPase family

    3. XM_006534697.3 → XP_006534760.1  putative GTP-binding protein 6 isoform X1

      UniProtKB/TrEMBL
      Q8VDE1
      Conserved Domains (1) summary
      COG2262
      Location:3 → 399
      HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]

    4. XM_006534701.3 → XP_006534764.1  putative GTP-binding protein 6 isoform X2

      See identical proteins and their annotated locations for XP_006534764.1

      UniProtKB/TrEMBL
      Q8VDE1
      Conserved Domains (2) summary
      cd01878
      Location:113 → 284
      HflX; HflX GTPase family
      pfam16360
      Location:42 → 90
      GTP-bdg_M; GTP-binding GTPase Middle Region

    5. XM_030254037.1 → XP_030109897.1  putative GTP-binding protein 6 isoform X3

      UniProtKB/TrEMBL
      Q8VDE1
      Conserved Domains (1) summary
      COG2262
      Location:3 → 334
      HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]

    6. XM_006534700.3 → XP_006534763.1  putative GTP-binding protein 6 isoform X2

      See identical proteins and their annotated locations for XP_006534763.1

      UniProtKB/TrEMBL
      Q8VDE1
      Conserved Domains (2) summary
      cd01878
      Location:113 → 284
      HflX; HflX GTPase family
      pfam16360
      Location:42 → 90
      GTP-bdg_M; GTP-binding GTPase Middle Region

    7. XM_036164714.1 → XP_036020607.1  putative GTP-binding protein 6 isoform X3

      UniProtKB/TrEMBL
      Q8VDE1
      Conserved Domains (1) summary
      COG2262
      Location:3 → 334
      HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]

    8. XM_036164713.1 → XP_036020606.1  putative GTP-binding protein 6 isoform X2

      UniProtKB/TrEMBL
      Q8VDE1
      Conserved Domains (2) summary
      cd01878
      Location:113 → 284
      HflX; HflX GTPase family
      pfam16360
      Location:42 → 90
      GTP-bdg_M; GTP-binding GTPase Middle Region

    9. XM_036164715.1 → XP_036020608.1  putative GTP-binding protein 6 isoform X3

      UniProtKB/TrEMBL
      Q8VDE1
      Related
      ENSMUST00000127628.6
      Conserved Domains (1) summary
      COG2262
      Location:3 → 334
      HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]

    10. XM_030254040.2 → XP_030109900.1  putative GTP-binding protein 6 isoform X4

      UniProtKB/TrEMBL
      Q8K372
      Conserved Domains (1) summary
      cd01878
      Location:65 → 236
      HflX; HflX GTPase family

    11. XM_036164717.1 → XP_036020610.1  putative GTP-binding protein 6 isoform X4

      UniProtKB/TrEMBL
      Q8K372
      Conserved Domains (1) summary
      cd01878
      Location:65 → 236
      HflX; HflX GTPase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U6U5.1 GenPept UniProtKB/Swiss-Prot:Q3U6U5

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