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    Usp9y ubiquitin specific peptidase 9, Y chromosome [ Mus musculus (house mouse) ]

    Gene ID: 107868, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Usp9yprovided by MGI
    Official Full Name
    ubiquitin specific peptidase 9, Y chromosomeprovided by MGI
    Primary source
    MGI:MGI:1313274
    See related
    Ensembl:ENSMUSG00000069044 AllianceGenome:MGI:1313274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dffry; Fafl2
    Summary
    Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in cell migration and protein deubiquitination. Predicted to be active in cytosol and nucleus. Is expressed in brain; lung; and testis. Human ortholog(s) of this gene implicated in Y-linked spermatogenic failure 2. Orthologous to human USP9Y (ubiquitin specific peptidase 9 Y-linked). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    Y; Ypter
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (1298961..1459782, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (1298961..1459782, complement)

    Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48299 Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene DEAD box helicase 3, Y-linked Neighboring gene low density lipoprotein receptor-related protein 8, apolipoprotein e receptor pseudogene Neighboring gene predicted gene, 25565 Neighboring gene STARR-seq mESC enhancer starr_48300 Neighboring gene jumonji C domain-containing histone demethylase 1 homolog D pseudogene Neighboring gene STARR-seq mESC enhancer starr_48301 Neighboring gene STARR-seq mESC enhancer starr_48302 Neighboring gene STARR-seq mESC enhancer starr_48303 Neighboring gene sacsin pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effect of the Y chromosome on testis weight in mice. Satou K, et al. J Vet Med Sci, 2015 Jun. PMID 25716571, Free PMC Article
    2. Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint. Hall NM, et al. Mamm Genome, 2003 Jul. PMID 12925892
    3. The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region. Mazeyrat S, et al. Hum Mol Genet, 1998 Oct. PMID 9736773
    4. The role of Dby mRNA in early development of male mouse zygotes. Yao CJ, et al. Asian J Androl, 2010 Jul. PMID 20543856, Free PMC Article
    5. Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene. Brown GM, et al. Hum Mol Genet, 1998 Jan. PMID 9384609

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Variations in Usp9y and the number of CAG repeats in Sry are significantly associated with testes weight.
      Title: Effect of the Y chromosome on testis weight in mice.
    2. Selection is acting to maintain the amino acid sequence of both the X and the Y-linked genes.
      Title: Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 9Y
    Names
    ubiquitin specific protease 9, Y chromosome
    NP_683745.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148943.2 → NP_683745.2  ubiquitin carboxyl-terminal hydrolase 9Y

      See identical proteins and their annotated locations for NP_683745.2

      Status: VALIDATED

      Source sequence(s)
      AC145393, AC145592
      Consensus CDS
      CCDS30544.1
      UniProtKB/Swiss-Prot
      F8VPU6, Q91XW2
      Related
      ENSMUSP00000088727.6, ENSMUST00000091188.7
      Conserved Domains (2) summary
      cd02659
      Location:1557 → 1960
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1559 → 1955
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000087.8 Reference GRCm39 C57BL/6J

      Range
      1298961..1459782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F8VPU6.1 GenPept UniProtKB/Swiss-Prot:F8VPU6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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