Haao 3-hydroxyanthranilate 3,4-dioxygenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Haaoprovided by MGI
Official Full Name: 3-hydroxyanthranilate 3,4-dioxygenaseprovided by MGI
Primary source: MGI:MGI:1349444
See related: Ensembl:ENSMUSG00000000673 AllianceGenome:MGI:1349444
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3HAO; 3-HAO; 3-HAOxase; 0610007K21Rik; 0610012J07Rik
Summary: Enables 3-hydroxyanthranilate 3,4-dioxygenase activity. Predicted to be involved in several processes, including pyridine-containing compound biosynthetic process; response to cadmium ion; and response to zinc ion. Predicted to act upstream of or within pyridine nucleotide biosynthetic process. Predicted to be located in cytosol and mitochondrial membrane. Predicted to be active in cytoplasm. Is expressed in ductus deferens; epididymis; esophagus; metanephros; and testis. Orthologous to human HAAO (3-hydroxyanthranilate 3,4-dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 126.1), kidney adult (RPKM 31.2) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E4; 17 54.85 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (84138777..84157589, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (83831348..83848981, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In mouse embryos there was no significant upregulation of Haao expression in the developing male external genitalia. Irx6 was expressed in the ectodermal epithelium, demonstrating prominent dorsal ectodermal expression without expression in the ventral ectoderm adjacent to the urethral plate during the same period.
Title: Single Nucleotide Polymorphisms of HAAO and IRX6 Genes as Risk Factors for Hypospadias.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-hydroxyanthranilate 3,4-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-hydroxyanthranilate 3,4-dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-hydroxyanthranilate 3,4-dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxygen binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan	IBA Inferred from Biological aspect of Ancestor more info
involved_in NAD biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in quinolinate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in quinolinate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in quinolinate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in response to zinc ion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 3-hydroxyanthranilate 3,4-dioxygenase

Names: 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; HAD

NP_079601.1

EC 1.13.11.6

XP_006523526.1

EC 1.13.11.6

XP_006523528.1

EC 1.13.11.6

XP_030105301.1

EC 1.13.11.6

XP_030105302.1

EC 1.13.11.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025325.2 → NP_079601.1 3-hydroxyanthranilate 3,4-dioxygenase

See identical proteins and their annotated locations for NP_079601.1

Status: PROVISIONAL

Source sequence(s)

BC094021

Consensus CDS

CCDS37709.1

UniProtKB/Swiss-Prot

Q52L88, Q78JT3

Related

ENSMUSP00000000687.8, ENSMUST00000000687.9

Conserved Domains (2) summary

cd06123
Location:10 → 159

cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain

cl40423
Location:209 → 260

cupin_RmlC-like; RmlC-like cupin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

84138777..84157589 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523463.5 → XP_006523526.1 3-hydroxyanthranilate 3,4-dioxygenase isoform X1

See identical proteins and their annotated locations for XP_006523526.1

UniProtKB/Swiss-Prot

Q52L88, Q78JT3

Conserved Domains (2) summary

cd06123
Location:10 → 159

cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain

cl40423
Location:209 → 260

cupin_RmlC-like; RmlC-like cupin superfamily
XM_030249442.2 → XP_030105302.1 3-hydroxyanthranilate 3,4-dioxygenase isoform X3

Conserved Domains (2) summary

cd06123
Location:1 → 98

cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain

cl40423
Location:148 → 199

cupin_RmlC-like; RmlC-like cupin superfamily
XM_006523465.5 → XP_006523528.1 3-hydroxyanthranilate 3,4-dioxygenase isoform X2

Conserved Domains (2) summary

cd06123
Location:1 → 125

cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain

cl40423
Location:175 → 226

cupin_RmlC-like; RmlC-like cupin superfamily
XM_030249441.2 → XP_030105301.1 3-hydroxyanthranilate 3,4-dioxygenase isoform X1

UniProtKB/Swiss-Prot

Q52L88, Q78JT3

Conserved Domains (2) summary

cd06123
Location:10 → 159

cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain

cl40423
Location:209 → 260

cupin_RmlC-like; RmlC-like cupin superfamily