Osr2 odd-skipped related 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Osr2provided by MGI
Official Full Name: odd-skipped related 2provided by MGI
Primary source: MGI:MGI:1930813
See related: Ensembl:ENSMUSG00000022330 AllianceGenome:MGI:1930813
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Osr2A; Osr2B; 5430409I15Rik
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; embryonic limb morphogenesis; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including embryonic skeletal system morphogenesis; kidney development; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human OSR2 (odd-skipped related transciption factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 68.7), subcutaneous fat pad adult (RPKM 65.0) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 14.46 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (35296244..35303451)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (35296098..35303305)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of Odd-Skipped Related 2, a Novel Regulator of Epithelial-Mesenchymal Transition, Enables Efficient Somatic Cell Reprogramming.
Title: Downregulation of Odd-Skipped Related 2, a Novel Regulator of Epithelial-Mesenchymal Transition, Enables Efficient Somatic Cell Reprogramming.
Osr2 controls multiple molecular pathways, including BMP and Sema3 signaling, in palate development.
Title: Identification of Osr2 Transcriptional Target Genes in Palate Development.
these data reveal a novel mechanism that the Bmp4-Msx1 pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt antagonists.
Title: Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists.
Osr2 functions in reproductive system organs, such as the uterus, testes, prostate, placenta, and ovaries.
Title: Expression pattern of zinc-finger transcription factor Odd-skipped related 2 in murine development and neonatal stage.
Bmp4 signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including Dkk2 and Osr2, and synergizes with Msx1 to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation
Title: Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.
These results suggest that Osr2 is involved in TGF-beta regulating cell migration and cell cycle via a Smad3-ATF2 transcriptional complex mediating pathway.
Title: Negative regulation of Odd-skipped related 2 by TGF-beta achieves the induction of cellular migration and the arrest of cell cycle.
Mice lacking both Osr2 and Pax9 exhibited early tooth developmental arrest with significantly reduced Bmp4 and Msx1 mRNA expression in the developing tooth mesenchyme.
Title: Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field.
These data indicate that Osr1 and Osr2 function redundantly to control synovial joint formation.
Title: The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation.
Osr2 plays important roles in cell proliferation and development.
Title: Odd-skipped related 2 regulates genes related to proliferation and development.
the distinct functions of Osr1 and Osr2 during mouse development result from evolutionary divergence of their cis regulatory sequences rather than distinct biochemical activities of their protein products.
Title: Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Osr2 (e-PCR), detects polymorphism
- UniSTS:525927

Osr2 (e-PCR), detects polymorphism
- UniSTS:466568

Osr2 (e-PCR), detects polymorphism
- UniSTS:547553

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic digit morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic forelimb morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic forelimb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic hindlimb morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic hindlimb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic skeletal joint development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic skeletal joint morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic skeletal limb joint morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eyelid development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesonephros development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephros development	IEP Inferred from Expression Pattern more info	PubMed
involved_in middle ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of bone mineralization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urogenital system development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein odd-skipped-related 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368665.1 → NP_001355594.1 protein odd-skipped-related 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC116596

Consensus CDS

CCDS88748.1

UniProtKB/Swiss-Prot

Q8BPV6, Q91V54, Q91ZD1

Related

ENSMUSP00000154286.2, ENSMUST00000228152.2

Conserved Domains (3) summary

COG5048
Location:251 → 312

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:174 → 194

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:186 → 211

zf-H2C2_2; Zinc-finger double domain
NM_054049.3 → NP_473390.1 protein odd-skipped-related 2 isoform 2

See identical proteins and their annotated locations for NP_473390.1

Status: VALIDATED

Source sequence(s)

AC116596

Consensus CDS

CCDS27422.1

UniProtKB/Swiss-Prot

Q91ZD1

Related

ENSMUSP00000022952.5, ENSMUST00000022952.6

Conserved Domains (2) summary

sd00017
Location:174 → 194

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:214 → 237

zf-H2C2_2; Zinc-finger double domain