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    Nt5c3 5'-nucleotidase, cytosolic III [ Mus musculus (house mouse) ]

    Gene ID: 107569, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nt5c3provided by MGI
    Official Full Name
    5'-nucleotidase, cytosolic IIIprovided by MGI
    Primary source
    MGI:MGI:1927186
    See related
    Ensembl:ENSMUSG00000029780 AllianceGenome:MGI:1927186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p36; Nt5y; PN-1; PN-I; PSN1; UMPH; P5N-1; Umph1; lupin; Nt5c3a; P5'N-1; Umph-1; cN-III; 1600024P05Rik; 2610206B05Rik; 3110004A18Rik
    Summary
    Enables 5'-nucleotidase activity. Involved in CMP catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; hemolymphoid system; liver; nervous system; and respiratory system. Orthologous to human NT5C3A (5'-nucleotidase, cytosolic IIIA). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 44.0), liver E14.5 (RPKM 35.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nt5c3 in Genome Data Viewer
    Location:
    6 B3; 6 27.75 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (56859385..56900993, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (56882400..56924008, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB (POZ) domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_15991 Neighboring gene STARR-positive B cell enhancer ABC_E4829 Neighboring gene predicted gene 10209 Neighboring gene STARR-seq mESC enhancer starr_15993 Neighboring gene FK506 binding protein 9 Neighboring gene STARR-seq mESC enhancer starr_15995 Neighboring gene predicted gene, 53332 Neighboring gene STARR-positive B cell enhancer ABC_E8830 Neighboring gene STARR-seq mESC enhancer starr_15996 Neighboring gene vomeronasal 1 receptor 4 Neighboring gene vomeronasal 1 receptor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The functional logic of cytosolic 5'-nucleotidases. Ipata PL, et al. Curr Med Chem, 2013. PMID 23992316
    2. The enzymology of cytosolic pyrimidine 5'-nucleotidases: functional analysis and physiopathological implications. Magni G, et al. Curr Med Chem, 2013. PMID 23992312
    3. Structural basis of substrate specificity and selectivity of murine cytosolic 5'-nucleotidase III. Grobosky CL, et al. J Mol Biol, 2012 Nov 2. PMID 22925580
    4. Cloning and expression analysis of murine lupin, a member of a novel gene family that is conserved through evolution and associated with Lupus inclusions. Lu MM, et al. Dev Genes Evol, 2000 Oct. PMID 11180800
    5. Isozymes of rodent 5'-nucleotidase: evidence for two independent structural loci Umph-1 and Umph-2. Swallow DM, et al. Ann Hum Genet, 1983 Jan. PMID 6301357

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 5'-nucleotidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables XMP 5'-nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dCMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dTMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dUMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic 5'-nucleotidase 3A
    Names
    5'-nucleotidase, pyrimidine
    7-methylguanosine nucleotidase
    7-methylguanosine phosphate-specific 5'-nucleotidase
    cytosolic 5'-nucleotidase 3
    cytosolic 5'-nucleotidase III
    pyrimidine 5'-nucleotidase 1
    uridine monophosphatase 1
    NP_001239303.1
    NP_001347892.1
    NP_080280.3
    XP_006505336.1
    XP_006505337.1
    XP_006505338.1
    XP_006505339.1
    XP_011239413.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252374.1 → NP_001239303.1  cytosolic 5'-nucleotidase 3A isoform 2

      See identical proteins and their annotated locations for NP_001239303.1

      Status: VALIDATED

      Source sequence(s)
      AC153616, AK160139, BX527194, CX734167
      Consensus CDS
      CCDS57424.1
      UniProtKB/Swiss-Prot
      Q9D020
      Related
      ENSMUSP00000098918.3, ENSMUST00000101367.9
      Conserved Domains (1) summary
      cd07504
      Location:25 → 297
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    2. NM_001360963.1 → NP_001347892.1  cytosolic 5'-nucleotidase 3A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153616, BX527194
      Consensus CDS
      CCDS57424.1
      Conserved Domains (1) summary
      cd07504
      Location:25 → 297
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    3. NM_026004.3 → NP_080280.3  cytosolic 5'-nucleotidase 3A isoform 1

      See identical proteins and their annotated locations for NP_080280.3

      Status: VALIDATED

      Source sequence(s)
      AK011525, AK011894, BX527194, BY261587
      Consensus CDS
      CCDS20171.1
      UniProtKB/Swiss-Prot
      Q8CI05, Q9D020, Q9D0D9
      Related
      ENSMUSP00000031793.6, ENSMUST00000031793.8
      Conserved Domains (1) summary
      cd07504
      Location:59 → 331
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      56859385..56900993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241111.2 → XP_011239413.1  cytosolic 5'-nucleotidase 3A isoform X1

      See identical proteins and their annotated locations for XP_011239413.1

      UniProtKB/Swiss-Prot
      Q9D020
      Conserved Domains (1) summary
      cd07504
      Location:25 → 297
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    2. XM_006505275.3 → XP_006505338.1  cytosolic 5'-nucleotidase 3A isoform X3

      Conserved Domains (1) summary
      cd07504
      Location:14 → 286
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    3. XM_006505274.3 → XP_006505337.1  cytosolic 5'-nucleotidase 3A isoform X2

      Conserved Domains (1) summary
      cd07504
      Location:20 → 292
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    4. XM_006505273.3 → XP_006505336.1  cytosolic 5'-nucleotidase 3A isoform X1

      See identical proteins and their annotated locations for XP_006505336.1

      UniProtKB/Swiss-Prot
      Q9D020
      Conserved Domains (1) summary
      cd07504
      Location:25 → 297
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    5. XM_006505276.5 → XP_006505339.1  cytosolic 5'-nucleotidase 3A isoform X4

      Conserved Domains (1) summary
      cd07504
      Location:13 → 285
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D020.4 GenPept UniProtKB/Swiss-Prot:Q9D020

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