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    Gimap4 GTPase, IMAP family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 107526, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Gimap4provided by MGI
    Official Full Name
    GTPase, IMAP family member 4provided by MGI
    Primary source
    MGI:MGI:1349656
    See related
    Ensembl:ENSMUSG00000054435 AllianceGenome:MGI:1349656
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ian1; Ian-1; Imap4; E430007K16Rik
    Summary
    This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. This gene exists within a cluster of other related genes located on mouse chromosome 6. This family member encodes a lymphoid signaling protein that functions to accelerate programmed T-cell death, which appears to correlate with the phosphorylation status of the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
    Expression
    Broad expression in spleen adult (RPKM 17.4), mammary gland adult (RPKM 13.3) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B2.3; 6 23.66 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48661453..48668996)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48684578..48692062)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 44262 Neighboring gene predicted gene, 46958 Neighboring gene GTPase, IMAP family member 9 Neighboring gene STARR-positive B cell enhancer ABC_E3653 Neighboring gene GTPase, IMAP family member 6 Neighboring gene STARR-positive B cell enhancer ABC_E8100 Neighboring gene STARR-positive B cell enhancer ABC_E6427 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:48668564-48668753 Neighboring gene GTPase, IMAP family member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gimap4 accelerates T-cell death. Schnell S, et al. Blood, 2006 Jul 15. PMID 16569770
    2. Proteomics analysis of interleukin (IL)-7-induced signaling effectors shows selective changes in IL-7Ralpha449F knock-in T cell progenitors. Duthie KA, et al. Mol Cell Proteomics, 2007 Oct. PMID 17602185
    3. Immune-associated nucleotide-1 (IAN-1) is a thymic selection marker and defines a novel gene family conserved in plants. Poirier GM, et al. J Immunol, 1999 Nov 1. PMID 10528200
    4. Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36. Stamm O, et al. Gene, 2002 Jan 9. PMID 11814688
    5. IAN family critically regulates survival and development of T lymphocytes. Nitta T, et al. PLoS Biol, 2006 Apr. PMID 16509771, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11734

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GTPase IMAP family member 4
    Names
    immune associated nucleotide 1
    immunity-associated protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243199.1 → NP_001230128.1  GTPase IMAP family member 4 isoform c

      See identical proteins and their annotated locations for NP_001230128.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate segment that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC153894, BG092483
      Consensus CDS
      CCDS57423.1
      UniProtKB/Swiss-Prot
      Q99JY3
      Related
      ENSMUSP00000068398.8, ENSMUST00000067506.14
      Conserved Domains (1) summary
      cd01852
      Location:31 → 212
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)

    2. NM_001243200.1 → NP_001230129.1  GTPase IMAP family member 4 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame segment in the central coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
      Source sequence(s)
      AC153894, BG092483
      Consensus CDS
      CCDS57421.1
      UniProtKB/TrEMBL
      D3YWB5
      Related
      ENSMUSP00000112530.2, ENSMUST00000118802.8
      Conserved Domains (1) summary
      cl21455
      Location:49 → 102
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001243201.1 → NP_001230130.1  GTPase IMAP family member 4 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate segment that spans both the central and 3' coding regions, and which results in a frameshift, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC153894, BC098226, BG092483
      Consensus CDS
      CCDS57422.1
      UniProtKB/TrEMBL
      D3Z3F3
      Related
      ENSMUSP00000113989.2, ENSMUST00000119575.8
      Conserved Domains (1) summary
      cl21455
      Location:31 → 48
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_174990.4 → NP_778155.2  GTPase IMAP family member 4 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC153894, BG092483, CA576036
      Consensus CDS
      CCDS20110.1
      UniProtKB/Swiss-Prot
      D3YTN4, Q99JY3
      Related
      ENSMUSP00000087524.5, ENSMUST00000090070.6
      Conserved Domains (1) summary
      pfam04548
      Location:31 → 230
      AIG1; AIG1 family

    5. NM_175048.3 → NP_778213.2  GTPase IMAP family member 4 isoform b

      See identical proteins and their annotated locations for NP_778213.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks both an in-frame segment in the central coding region and a large segment in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AA543119, AA795946, AC153894, BG092483
      Consensus CDS
      CCDS39481.2
      UniProtKB/TrEMBL
      D3Z7Q4
      Related
      ENSMUSP00000113016.2, ENSMUST00000121957.8
      Conserved Domains (1) summary
      cl21455
      Location:49 → 84
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      48661453..48668996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165721.1 → XP_036021614.1  GTPase IMAP family member 4 isoform X1

      Conserved Domains (1) summary
      cd01852
      Location:31 → 212
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JY3.2 GenPept UniProtKB/Swiss-Prot:Q99JY3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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