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    Unc5b unc-5 netrin receptor B [ Mus musculus (house mouse) ]

    Gene ID: 107449, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Unc5bprovided by MGI
    Official Full Name
    unc-5 netrin receptor Bprovided by MGI
    Primary source
    MGI:MGI:894703
    See related
    Ensembl:ENSMUSG00000020099 AllianceGenome:MGI:894703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Unc5h2; A630020F16; D10Bwg0792e; 6330415E02Rik
    Summary
    Predicted to enable netrin receptor activity. Acts upstream of or within anterior/posterior axon guidance. Predicted to be located in membrane raft. Is expressed in several structures, including brain; forelimb; ganglia; limb bud; and sensory organ. Orthologous to human UNC5B (unc-5 netrin receptor B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in small intestine adult (RPKM 21.1), colon adult (RPKM 20.9) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B4; 10 31.52 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (60598373..60667360, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (60762594..60831581, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57560 Neighboring gene STARR-seq mESC enhancer starr_26811 Neighboring gene solute carrier family 29 (nucleoside transporters), member 3 Neighboring gene STARR-seq mESC enhancer starr_26812 Neighboring gene STARR-positive B cell enhancer ABC_E2326 Neighboring gene STARR-positive B cell enhancer ABC_E2939 Neighboring gene VISTA enhancer mm1663 Neighboring gene STARR-seq mESC enhancer starr_26820 Neighboring gene predicted gene, 36750 Neighboring gene microRNA 6408

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior. Dudok B, et al. Neuron, 2021 Dec 1. PMID 34648750, Free PMC Article
    2. Deletion of UNC5B in Kidney Epithelium Exacerbates Diabetic Nephropathy in Mice. Ranganathan P, et al. Am J Nephrol, 2015. PMID 25896231, Free PMC Article
    3. UNC5B receptor deletion exacerbates DSS-induced colitis in mice by increasing epithelial cell apoptosis. Ranganathan P, et al. J Cell Mol Med, 2014 Jul. PMID 24720832, Free PMC Article
    4. UNC5B receptor deletion exacerbates tissue injury in response to AKI. Ranganathan P, et al. J Am Soc Nephrol, 2014 Feb. PMID 24115477, Free PMC Article
    5. The uncoordinated-5 homolog B (UNC5B) receptor increases myocardial ischemia-reperfusion injury. Köhler D, et al. PLoS One, 2013. PMID 23936025, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development.
      Title: Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development.
    2. GPC3-Unc5 receptor complex structure and role in cell migration.
      Title: GPC3-Unc5 receptor complex structure and role in cell migration.
    3. Endothelial Unc5B controls blood-brain barrier integrity.
      Title: Endothelial Unc5B controls blood-brain barrier integrity.
    4. Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease.
      Title: Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease.
    5. Polyomavirus Small T Antigen Induces Apoptosis in Mammalian Cells through the UNC5B Pathway in a PP2A-Dependent Manner.
      Title: Polyomavirus Small T Antigen Induces Apoptosis in Mammalian Cells through the UNC5B Pathway in a PP2A-Dependent Manner.
    6. Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells.
      Title: Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells.
    7. Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signaling.
      Title: Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling.
    8. Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation.
      Title: Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-α-Acetyltransferase 10 (Naa10).
    9. fibronectin leucine-rich transmembrane protein 2 (FLRT2), a repulsive ligand of the UNC5 receptor family for neurons, is unexpectedly expressed in endothelial cells specifically in the placental labyrinth.
      Title: Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling.
    10. Blockade of Netrin-1/Unc5b by monoclonal antibodies prevents bone destruction and reduces the severity of K/BxN serum transfer-induced arthritis
      Title: Netrin-1 and its receptor Unc5b are novel targets for the treatment of inflammatory arthritis.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (5)  1 citation
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables netrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables netrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anterior/posterior axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within anterior/posterior axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in netrin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    netrin receptor UNC5B
    Names
    protein unc-5 homolog 2
    protein unc-5 homolog B
    unc5 homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359273.1 → NP_001346202.1  netrin receptor UNC5B isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AK018177, AK147603, AW488068, BC048162
      Consensus CDS
      CCDS88011.1
      UniProtKB/TrEMBL
      Q3TYW6
      Related
      ENSMUSP00000151251.2, ENSMUST00000218637.2
      Conserved Domains (5) summary
      smart00218
      Location:530 → 633
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08802
      Location:847 → 930
      Death_UNC5B; Death domain found in Uncoordinated-5B
      smart00209
      Location:249 → 300
      TSP1; Thrombospondin type 1 repeats
      pfam17217
      Location:680 → 819
      UPA; UPA domain
      cl11960
      Location:157 → 243
      Ig; Immunoglobulin domain

    2. NM_029770.3 → NP_084046.2  netrin receptor UNC5B isoform 1 precursor

      See identical proteins and their annotated locations for NP_084046.2

      Status: VALIDATED

      Source sequence(s)
      AK018177, AK147603, AK158284, AW488068, BC048162
      Consensus CDS
      CCDS23872.1
      UniProtKB/Swiss-Prot
      Q3U4F2, Q6PFH0, Q80Y85, Q8K1S3, Q9D398
      UniProtKB/TrEMBL
      Q3TYW6
      Related
      ENSMUSP00000077080.6, ENSMUST00000077925.7
      Conserved Domains (5) summary
      smart00218
      Location:541 → 644
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08802
      Location:858 → 941
      Death_UNC5B; Death domain found in Uncoordinated-5B
      smart00209
      Location:249 → 300
      TSP1; Thrombospondin type 1 repeats
      pfam07679
      Location:155 → 243
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:157 → 243
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      60598373..60667360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1S3.1 GenPept UniProtKB/Swiss-Prot:Q8K1S3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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