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    Kazald1 Kazal-type serine peptidase inhibitor domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 107250, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Kazald1provided by MGI
    Official Full Name
    Kazal-type serine peptidase inhibitor domain 1provided by MGI
    Primary source
    MGI:MGI:2147606
    See related
    Ensembl:ENSMUSG00000025213 AllianceGenome:MGI:2147606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bono1; IGFBP-rP10
    Summary
    Predicted to enable insulin-like growth factor binding activity. Acts upstream of or within extracellular matrix organization. Located in interstitial matrix. Is expressed in several structures, including bone; cap mesenchyme; jaw; nose; and testis. Orthologous to human KAZALD1 (Kazal type serine peptidase inhibitor domain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 22.4), ovary adult (RPKM 14.9) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 38.32 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (45063404..45067728)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (45074962..45079289)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene leucine zipper, putative tumor suppressor 2 Neighboring gene PDZ domain containing 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:45131818-45132020 Neighboring gene STARR-positive B cell enhancer ABC_E9175 Neighboring gene sideroflexin 3 Neighboring gene predicted gene, 35782 Neighboring gene STARR-seq mESC enhancer starr_46258 Neighboring gene STARR-seq mESC enhancer starr_46259 Neighboring gene predicted gene, 35867 Neighboring gene STARR-seq mESC enhancer starr_46262 Neighboring gene predicted gene, 35923

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of a new member of IGFBP superfamily, IGFBP-rP10, in proliferation and differentiation of osteoblastic cells. Shibata Y, et al. Biochem Biophys Res Commun, 2004 Dec 24. PMID 15555553
    2. Quantitative trait locus mapping of genes that control body length and plasma insulin-like growth factor 1 level in mice. Suto J. BMC Res Notes, 2012 Oct 2. PMID 23031221, Free PMC Article
    3. Bono1: a gene associated with regions of deposition of bone and dentine. James MJ, et al. Gene Expr Patterns, 2004 Sep. PMID 15261838
    4. Different roles of Runx2 during early neural crest-derived bone and tooth development. James MJ, et al. J Bone Miner Res, 2006 Jul. PMID 16813524
    5. Activin A Determines Steroid Levels and Composition in the Fetal Testis. Whiley PAF, et al. Endocrinology, 2020 Jul 1. PMID 32274496

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that IGFBP-rP10 is involved in the proliferation of osteoblasts during bone formation and bone regeneration.
      Title: Role of a new member of IGFBP superfamily, IGFBP-rP10, in proliferation and differentiation of osteoblastic cells.
    2. Expression of Bono1 was detected in osteoblasts and secretory odontoblasts by in situ hybridization.
      Title: Bono1: a gene associated with regions of deposition of bone and dentine.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in interstitial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in interstitial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kazal-type serine protease inhibitor domain-containing protein 1
    Names
    IGFBP-related protein 10
    Kazal-type serine protease inhibitor domain 1
    bone and odontoblast-expressed protein 1
    insulin-like growth factor-binding-related protein 10
    insulin-like growth factor-binding-related protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362397.1 → NP_001349326.1  kazal-type serine protease inhibitor domain-containing protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC132957
      UniProtKB/TrEMBL
      Q3U2U8
      Conserved Domains (3) summary
      cd00104
      Location:136 → 175
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam00219
      Location:61 → 115
      IGFBP; Insulin-like growth factor binding protein
      pfam07679
      Location:179 → 277
      I-set; Immunoglobulin I-set domain

    2. NM_001362398.1 → NP_001349327.1  kazal-type serine protease inhibitor domain-containing protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC132957
      Consensus CDS
      CCDS29857.1
      UniProtKB/Swiss-Prot
      Q14BR9, Q8BJ66
      UniProtKB/TrEMBL
      Q3U2U8
      Related
      ENSMUSP00000107579.2, ENSMUST00000111948.8
      Conserved Domains (4) summary
      cd00104
      Location:136 → 175
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam00219
      Location:61 → 115
      IGFBP; Insulin-like growth factor binding protein
      pfam07679
      Location:179 → 277
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:187 → 190
      Ig; Ig strand A' [structural motif]

    3. NM_178929.5 → NP_849260.2  kazal-type serine protease inhibitor domain-containing protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_849260.2

      Status: VALIDATED

      Source sequence(s)
      AI842353, AI847274, BB618180, BB869960, BB871162, BC115642
      Consensus CDS
      CCDS29857.1
      UniProtKB/Swiss-Prot
      Q14BR9, Q8BJ66
      UniProtKB/TrEMBL
      Q3U2U8
      Related
      ENSMUSP00000026234.5, ENSMUST00000026234.5
      Conserved Domains (4) summary
      cd00104
      Location:136 → 175
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam00219
      Location:61 → 115
      IGFBP; Insulin-like growth factor binding protein
      pfam07679
      Location:179 → 277
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:187 → 190
      Ig; Ig strand A' [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      45063404..45067728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526567.4 → XP_006526630.1  kazal-type serine protease inhibitor domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006526630.1

      UniProtKB/Swiss-Prot
      Q14BR9, Q8BJ66
      UniProtKB/TrEMBL
      Q3U2U8
      Conserved Domains (4) summary
      cd00104
      Location:136 → 175
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam00219
      Location:61 → 115
      IGFBP; Insulin-like growth factor binding protein
      pfam07679
      Location:179 → 277
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:187 → 190
      Ig; Ig strand A' [structural motif]

    2. XM_030250686.2 → XP_030106546.1  kazal-type serine protease inhibitor domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q14BR9, Q8BJ66
      UniProtKB/TrEMBL
      Q3U2U8
      Conserved Domains (4) summary
      cd00104
      Location:136 → 175
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam00219
      Location:61 → 115
      IGFBP; Insulin-like growth factor binding protein
      pfam07679
      Location:179 → 277
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:187 → 190
      Ig; Ig strand A' [structural motif]

    3. XM_006526566.3 → XP_006526629.1  kazal-type serine protease inhibitor domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006526629.1

      UniProtKB/Swiss-Prot
      Q14BR9, Q8BJ66
      UniProtKB/TrEMBL
      Q3U2U8
      Conserved Domains (4) summary
      cd00104
      Location:136 → 175
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam00219
      Location:61 → 115
      IGFBP; Insulin-like growth factor binding protein
      pfam07679
      Location:179 → 277
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:187 → 190
      Ig; Ig strand A' [structural motif]

    4. XM_017318042.2 → XP_017173531.1  kazal-type serine protease inhibitor domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q14BR9, Q8BJ66
      UniProtKB/TrEMBL
      Q3U2U8
      Conserved Domains (4) summary
      cd00104
      Location:136 → 175
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam00219
      Location:61 → 115
      IGFBP; Insulin-like growth factor binding protein
      pfam07679
      Location:179 → 277
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:187 → 190
      Ig; Ig strand A' [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJ66.2 GenPept UniProtKB/Swiss-Prot:Q8BJ66

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