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    AI837181 expressed sequence AI837181 [ Mus musculus (house mouse) ]

    Gene ID: 107242, updated on 21-Apr-2024

    Summary

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    Official Symbol
    AI837181provided by MGI
    Official Full Name
    expressed sequence AI837181provided by MGI
    Primary source
    MGI:MGI:2147598
    See related
    Ensembl:ENSMUSG00000047423 AllianceGenome:MGI:2147598
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bles03
    Summary
    Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and integumental system. Orthologous to human C11orf68 (chromosome 11 open reading frame 68). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 47.5), ovary adult (RPKM 47.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 4.32 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5475172..5477345)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5425144..5427317)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930481A15 gene Neighboring gene predicted pseudogene 6293 Neighboring gene STARR-positive B cell enhancer ABC_E8929 Neighboring gene DR1 associated protein 1 Neighboring gene predicted gene, 25432 Neighboring gene predicted gene, 31070

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03. Bitto E, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Sep 1. PMID 16511166, Free PMC Article
    2. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural characterization of the human ortholog.
      Title: The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    UPF0696 protein C11orf68 homolog
    Names
    basophilic leukemia expressed protein
    basophilic leukemia-expressed protein Bles03
    protein WF-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256515.1 → NP_001243444.1  UPF0696 protein C11orf68 homolog isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site that causes a frameshift in the central and 3' coding regions, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a.
      Source sequence(s)
      AC122861, BC017542, BE993470, CK622392
      Consensus CDS
      CCDS89308.1
      UniProtKB/Swiss-Prot
      Q8VD62
      Related
      ENSMUSP00000158508.2, ENSMUST00000054477.8

    2. NM_134149.2 → NP_598910.2  UPF0696 protein C11orf68 homolog isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
      Source sequence(s)
      AV579065, BC017542, CJ181010
      Consensus CDS
      CCDS29463.2
      UniProtKB/Swiss-Prot
      E9QNR6, Q6LCE3, Q8VD62
      Related
      ENSMUSP00000125651.2, ENSMUST00000159759.3
      Conserved Domains (1) summary
      pfam08939
      Location:162 → 259
      DUF1917; Domain of unknown function (DUF1917)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5475172..5477345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VD62.2 GenPept UniProtKB/Swiss-Prot:Q8VD62

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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