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    Glyat glycine-N-acyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 107146, updated on 27-Feb-2024

    Summary

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    Official Symbol
    Glyatprovided by MGI
    Official Full Name
    glycine-N-acyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2147502
    See related
    Ensembl:ENSMUSG00000063683 AllianceGenome:MGI:2147502
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAT; GAT; ACGNAT; A330009E03Rik
    Summary
    Predicted to enable glycine N-acyltransferase activity and glycine N-benzoyltransferase activity. Predicted to be involved in benzoyl-CoA metabolic process and glycine metabolic process. Predicted to act upstream of or within response to toxic substance. Located in mitochondrion. Orthologous to human GLYAT (glycine-N-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 73.4), liver adult (RPKM 26.2) and 1 other tissue See more
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    Genomic context

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    Location:
    19 A; 19 8.73 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (12610672..12629101)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (12633308..12651737)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330040F15 gene Neighboring gene RIKEN cDNA 4122401K19 gene Neighboring gene predicted gene 4952 Neighboring gene STARR-seq mESC enhancer starr_45596 Neighboring gene predicted gene, 24521 Neighboring gene olfactory receptor family 5 subfamily B member 94

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression, purification, and characterization of mouse glycine N-acyltransferase in Escherichia coli. Dempsey DR, et al. Protein Expr Purif, 2014 May. PMID 24576660, Free PMC Article
    2. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycine N-benzoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine N-benzoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in benzoyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycine N-acyltransferase
    Names
    AAc
    acyl-CoA:glycine N-acyltransferase
    aralkyl acyl-CoA N-acyltransferase
    aralkyl acyl-CoA:amino acid N-acyltransferase
    benzoyl-coenzyme A:glycine N-acyltransferase
    glycine N-benzoyltransferase
    NP_666047.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145935.3 → NP_666047.1  glycine N-acyltransferase

      See identical proteins and their annotated locations for NP_666047.1

      Status: VALIDATED

      Source sequence(s)
      AK039262
      Consensus CDS
      CCDS29633.1
      UniProtKB/Swiss-Prot
      Q05DG2, Q91XE0
      Related
      ENSMUSP00000043308.6, ENSMUST00000044976.12
      Conserved Domains (2) summary
      pfam08444
      Location:207 → 295
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:11 → 206
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      12610672..12629101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XE0.1 GenPept UniProtKB/Swiss-Prot:Q91XE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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