Slc39a3 solute carrier family 39 (zinc transporter), member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc39a3provided by MGI
Official Full Name: solute carrier family 39 (zinc transporter), member 3provided by MGI
Primary source: MGI:MGI:2147269
See related: Ensembl:ENSMUSG00000046822 AllianceGenome:MGI:2147269
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zip3; ZIP-3
Summary: Enables zinc ion transmembrane transporter activity. Acts upstream of or within several processes, including T cell homeostasis; chordate embryonic development; and zinc ion transport. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including gonad; nervous system; sensory organ; spleen; and yolk sac. Orthologous to human SLC39A3 (solute carrier family 39 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 57.2), ovary adult (RPKM 21.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80864374..80873169, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81028540..81037338, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo.
Title: Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo.
The ZIP3 Zinc Transporter Is Localized to Mossy Fiber Terminals and Is Required for Kainate-Induced Degeneration of CA3 Neurons.
Title: The ZIP3 Zinc Transporter Is Localized to Mossy Fiber Terminals and Is Required for Kainate-Induced Degeneration of CA3 Neurons.
ZnT3 KO mice showed abnormality in trace fear conditioning is involved in associative fear memory and extinction, but not in innate fear.
Title: Zinc transporter 3 is involved in learned fear and extinction, but not in innate fear.
Znt-3-deficient mice lacking synaptic Zn also show less hippocampal cell damage following kainic acid injection. Zip transporters may provide selective therapeutic targets to protect these neurons from early Zn-induced neurodegeneration following injury.
Title: Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration.
Zip3 does not participate in the acquisition of Zn from maternal circulation for secretion into milk but, in contrast, primarily plays a role in the reuptake and cellular retention of Zn in the mammary gland from the previously secreted milk pool.
Title: Zip3 (Slc39a3) functions in zinc reuptake from the alveolar lumen in lactating mammary gland.
Slc39a3 apparently plays a critical role in zinc homeostasis when zinc is replete, but they play important, noncompensatory roles when this metal is deficient
Title: Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency.
ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc
Title: Structure, function, and regulation of a subfamily of mouse zinc transporter genes.
Knockout mice lacking Zip3 were generated and characterized.
Title: Generation and characterization of mice lacking the zinc uptake transporter ZIP3.
Reduced expression of Zip3 ultimately resulted in cell death, indicating that mammary epithelial cells have a unique requirement for Zip3-mediated Zn(2+) import.
Title: Zip3 plays a major role in zinc uptake into mammary epithelial cells and is regulated by prolactin.
The expression of zinc transporter 3 (ZnT3) starts early in development, lasts throughout embryonic life, and is detected in proliferative and differentiating areas of the brain in distinct chelatable vesicular zinc pools.
Title: Developmental expression of ZnT3 in mouse brain: correlation between the vesicular zinc transporter protein and chelatable vesicular zinc (CVZ) cells. Glial and neuronal CVZ cells interact.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

BB284490 (e-PCR)
- UniSTS:208576

D7Got4 (e-PCR)
- UniSTS:114635

AI845814 (e-PCR)
- UniSTS:166100

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within limb development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within zinc ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within zinc ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: zinc transporter ZIP3

Names: solute carrier family 39 member 3; zrt- and Irt-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358898.2 → NP_001345827.2 zinc transporter ZIP3

Status: VALIDATED

Source sequence(s)

AC152500

Consensus CDS

CCDS24041.1

UniProtKB/Swiss-Prot

Q99K24

Related

ENSMUSP00000113147.5, ENSMUST00000117276.11

Conserved Domains (1) summary

pfam02535
Location:5 → 312

Zip; ZIP Zinc transporter
NM_134135.3 → NP_598896.3 zinc transporter ZIP3

Status: VALIDATED

Source sequence(s)

AC152500

Consensus CDS

CCDS24041.1

UniProtKB/Swiss-Prot

Q99K24

Related

ENSMUSP00000057094.7, ENSMUST00000059551.7

Conserved Domains (1) summary

pfam02535
Location:5 → 312

Zip; ZIP Zinc transporter