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    Afap1l1 actin filament associated protein 1-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 106877, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Afap1l1provided by MGI
    Official Full Name
    actin filament associated protein 1-like 1provided by MGI
    Primary source
    MGI:MGI:2147199
    See related
    Ensembl:ENSMUSG00000033032 AllianceGenome:MGI:2147199
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to be located in several cellular components, including cell junction; cell projection; and cytoskeleton. Predicted to be active in cytosol. Is expressed in diaphragm; heart ventricle; lung; and vertebral axis musculature. Orthologous to human AFAP1L1 (actin filament associated protein 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 66.9), heart adult (RPKM 19.3) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 E1; 18 34.71 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61863333..61919733, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61730262..61786662, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1500015A07 gene Neighboring gene STARR-positive B cell enhancer ABC_E8720 Neighboring gene predicted gene, 17883 Neighboring gene GrpE-like 2, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E7594 Neighboring gene predicted gene, 41748 Neighboring gene STARR-seq mESC enhancer starr_44765 Neighboring gene predicted gene, 35919 Neighboring gene actin binding LIM protein family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E10996 Neighboring gene predicted gene, 35720

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. Samuels AL, et al. Blood, 2009 Apr 16. PMID 19064729
    2. Endothelial Cyp26b1 restrains murine heart valve growth during development. Ahuja N, et al. Dev Biol, 2022 Jun. PMID 35364055
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    actin filament-associated protein 1-like 1
    Names
    AFAP1-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178928.4 → NP_849259.2  actin filament-associated protein 1-like 1

      See identical proteins and their annotated locations for NP_849259.2

      Status: PROVISIONAL

      Source sequence(s)
      AC125157
      Consensus CDS
      CCDS50303.1
      UniProtKB/Swiss-Prot
      Q8BKB8, Q8BZI0
      UniProtKB/TrEMBL
      B2RSM5
      Related
      ENSMUSP00000113286.2, ENSMUST00000120472.2
      Conserved Domains (3) summary
      cd13306
      Location:210 → 315
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:419 → 518
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:226 → 316
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61863333..61919733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZI0.1 GenPept UniProtKB/Swiss-Prot:Q8BZI0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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