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    Stap2 signal transducing adaptor family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 106766, updated on 31-Mar-2024

    Summary

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    Official Symbol
    Stap2provided by MGI
    Official Full Name
    signal transducing adaptor family member 2provided by MGI
    Primary source
    MGI:MGI:2147039
    See related
    Ensembl:ENSMUSG00000038781 AllianceGenome:MGI:2147039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    STAP-2
    Summary
    Predicted to enable signaling adaptor activity. Located in plasma membrane. Orthologous to human STAP2 (signal transducing adaptor family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in large intestine adult (RPKM 46.6), duodenum adult (RPKM 34.0) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stap2 in Genome Data Viewer
    Location:
    17 D; 17 29.1 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56304074..56315558, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55997074..56008402, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene src homology 2 domain-containing transforming protein D Neighboring gene fibronectin type 3 and SPRY domain-containing protein Neighboring gene STARR-positive B cell enhancer ABC_E2497 Neighboring gene MPN domain containing Neighboring gene bolA-like 3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:56160654-56160880 Neighboring gene SH3-domain GRB2-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals. Saitoh K, et al. J Immunol, 2022 Jul 1. PMID 35725273
    2. Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic mice. Saito H, et al. Biochem Biophys Res Commun, 2021 Jan 22. PMID 33388414
    3. Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress. Ichii M, et al. Haematologica, 2021 Feb 1. PMID 31974192, Free PMC Article
    4. STAP-2 positively regulates FcεRI-mediated basophil activation and basophil-dependent allergic inflammatory reactions. Kashiwakura JI, et al. Int Immunol, 2019 Apr 26. PMID 30726917
    5. Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis. Fujita N, et al. Eur J Immunol, 2014 Jun. PMID 24733425

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation.
      Title: STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation.
    2. STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN.
      Title: STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN.
    3. STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals.
      Title: STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals.
    4. Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation.
      Title: Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation.
    5. Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress.
      Title: Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress.
    6. Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic mice.
      Title: Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic mice.
    7. The STAP-2 is an adaptor molecule that positively regulates FcepsilonRI-mediated basophil activation and basophil-dependent allergic inflammatory reactions.
      Title: STAP-2 positively regulates FcεRI-mediated basophil activation and basophil-dependent allergic inflammatory reactions.
    8. These findings indicate an essential role for STAP2 in the generation of a high-quality memory CD8+ CTLs periphery, and suggest the therapeutic potential of STAP2 in cancer patients.
      Title: Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation.
    9. results demonstrate a contribution of CCR7 to STAP-2-dependent enhancement of BCR-ABL-mediated cell growth in Ba/F3 cells
      Title: CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic Ba/F3 cells.
    10. signal transducing adaptor protein 2 (STAP-2) is involved in cell migration, proliferation, and melanogenesis as well as chemokine receptor expression and tumorigenesis in B16F10 melanoma cells
      Title: STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    signal-transducing adaptor protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410325.1 → NP_001397254.1  signal-transducing adaptor protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT009719
      UniProtKB/Swiss-Prot
      Q8BWS2, Q8R0L1
      Related
      ENSMUSP00000038130.7, ENSMUST00000043785.8

    2. NM_145934.3 → NP_666046.1  signal-transducing adaptor protein 2 isoform 1

      See identical proteins and their annotated locations for NP_666046.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
      Source sequence(s)
      AK050131, AW049765, CT009719
      Consensus CDS
      CCDS28889.1
      UniProtKB/Swiss-Prot
      Q8BWS2, Q8R0L1
      Conserved Domains (2) summary
      cd10404
      Location:151 → 247
      SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
      cl17171
      Location:9 → 135
      PH-like; Pleckstrin homology-like domain

    RNA

    1. NR_102313.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK050172, CT009719
      Related
      ENSMUST00000233494.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56304074..56315558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160253.1 → XP_036016146.1  signal-transducing adaptor protein 2 isoform X2

      Conserved Domains (2) summary
      cd10404
      Location:151 → 247
      SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
      cl17171
      Location:9 → 135
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0L1.1 GenPept UniProtKB/Swiss-Prot:Q8R0L1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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