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    Catsperd cation channel sperm associated auxiliary subunit delta [ Mus musculus (house mouse) ]

    Gene ID: 106757, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Catsperdprovided by MGI
    Official Full Name
    cation channel sperm associated auxiliary subunit deltaprovided by MGI
    Primary source
    MGI:MGI:2147030
    See related
    Ensembl:ENSMUSG00000040828 AllianceGenome:MGI:2147030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    619718; Gm6095; Tmem146; 4921529N20Rik; 4933402B14Rik
    Summary
    Involved in flagellated sperm motility and sperm capacitation. Located in sperm principal piece. Part of CatSper complex. Orthologous to human CATSPERD (cation channel sperm associated auxiliary subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 33.0), stomach adult (RPKM 5.5) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 D; 17 29.43 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56933917..56971456)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56626911..56664456)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36 Neighboring gene lon peptidase 1, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E3210 Neighboring gene predicted gene, 33461 Neighboring gene STARR-seq mESC enhancer starr_42897 Neighboring gene RAN binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_42898 Neighboring gene STARR-positive B cell enhancer ABC_E962 Neighboring gene calcyphosine, pseudogene Neighboring gene vimentin-type intermediate filament associated coiled-coil protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Chung JJ, et al. Cell, 2014 May 8. PMID 24813608, Free PMC Article
    2. C2cd6-encoded CatSperτ targets sperm calcium channel to Ca(2+) signaling domains in the flagellar membrane. Hwang JY, et al. Cell Rep, 2022 Jan 18. PMID 34998468, Free PMC Article
    3. Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility. Hwang JY, et al. Cell, 2019 May 30. PMID 31056283, Free PMC Article
    4. CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility. Chung JJ, et al. Elife, 2017 Feb 23. PMID 28226241, Free PMC Article
    5. Structure of a mammalian sperm cation channel complex. Lin S, et al. Nature, 2021 Jul. PMID 34225353

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm capacitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CatSper complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CatSper complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm principal piece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cation channel sperm-associated auxiliary subunit delta
    Names
    catSper-delta
    catSperdelta
    cation channel sperm-associated protein subunit delta
    transmembrane protein 146

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357897.1 → NP_001344826.1  cation channel sperm-associated auxiliary subunit delta isoform 2

      Status: VALIDATED

      Source sequence(s)
      AW045609, CT010491, CT485788
      UniProtKB/TrEMBL
      A0A3B2WD76
      Conserved Domains (1) summary
      pfam15020
      Location:1 → 467
      CATSPERD; Cation channel sperm-associated protein subunit delta

    2. NM_175350.3 → NP_780559.2  cation channel sperm-associated auxiliary subunit delta isoform 1 precursor

      See identical proteins and their annotated locations for NP_780559.2

      Status: VALIDATED

      Source sequence(s)
      CT010491, CT485788
      Consensus CDS
      CCDS50153.1
      UniProtKB/Swiss-Prot
      E7DZL7, E7DZL8, E9Q710, E9Q9F6, Q1JPR3, Q1LZJ6, Q8C5U5
      Related
      ENSMUSP00000108603.3, ENSMUST00000112979.4
      Conserved Domains (1) summary
      pfam15020
      Location:38 → 766
      CATSPERD; Cation channel sperm-associated protein subunit delta

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56933917..56971456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523433.4 → XP_006523496.1  cation channel sperm-associated auxiliary subunit delta isoform X9

      See identical proteins and their annotated locations for XP_006523496.1

      Conserved Domains (1) summary
      pfam15020
      Location:1 → 592
      CATSPERD; Cation channel sperm-associated protein subunit delta

    2. XM_006523436.4 → XP_006523499.1  cation channel sperm-associated auxiliary subunit delta isoform X11

      See identical proteins and their annotated locations for XP_006523499.1

      UniProtKB/TrEMBL
      A0A3B2WD76
      Conserved Domains (1) summary
      pfam15020
      Location:1 → 571
      CATSPERD; Cation channel sperm-associated protein subunit delta

    3. XM_006523430.5 → XP_006523493.1  cation channel sperm-associated auxiliary subunit delta isoform X7

      Conserved Domains (1) summary
      pfam15020
      Location:32 → 768
      CATSPERD; Cation channel sperm-associated protein subunit delta

    4. XM_030249429.2 → XP_030105289.1  cation channel sperm-associated auxiliary subunit delta isoform X12

      Conserved Domains (1) summary
      pfam15020
      Location:84 → 596
      CATSPERD; Cation channel sperm-associated protein subunit delta

    5. XM_006523424.4 → XP_006523487.2  cation channel sperm-associated auxiliary subunit delta isoform X1

      Conserved Domains (1) summary
      pfam15020
      Location:65 → 763
      CATSPERD; Cation channel sperm-associated protein subunit delta

    6. XM_006523428.3 → XP_006523491.1  cation channel sperm-associated auxiliary subunit delta isoform X5

      Conserved Domains (1) summary
      pfam15020
      Location:38 → 774
      CATSPERD; Cation channel sperm-associated protein subunit delta

    7. XM_006523434.4 → XP_006523497.1  cation channel sperm-associated auxiliary subunit delta isoform X9

      See identical proteins and their annotated locations for XP_006523497.1

      Conserved Domains (1) summary
      pfam15020
      Location:1 → 592
      CATSPERD; Cation channel sperm-associated protein subunit delta

    8. XM_006523437.4 → XP_006523500.1  cation channel sperm-associated auxiliary subunit delta isoform X11

      See identical proteins and their annotated locations for XP_006523500.1

      UniProtKB/TrEMBL
      A0A3B2WD76
      Conserved Domains (1) summary
      pfam15020
      Location:1 → 571
      CATSPERD; Cation channel sperm-associated protein subunit delta

    9. XM_030249428.1 → XP_030105288.1  cation channel sperm-associated auxiliary subunit delta isoform X10

      UniProtKB/TrEMBL
      A0A3B2WD76
      Conserved Domains (1) summary
      pfam15020
      Location:1 → 584
      CATSPERD; Cation channel sperm-associated protein subunit delta

    10. XM_030249431.1 → XP_030105291.1  cation channel sperm-associated auxiliary subunit delta isoform X14

      UniProtKB/TrEMBL
      A0A3B2WD76
      Conserved Domains (1) summary
      pfam15020
      Location:9 → 454
      CATSPERD; Cation channel sperm-associated protein subunit delta

    11. XM_030249424.1 → XP_030105284.1  cation channel sperm-associated auxiliary subunit delta isoform X3

      Conserved Domains (1) summary
      pfam15020
      Location:1 → 549
      CATSPERD; Cation channel sperm-associated protein subunit delta

    12. XM_030249425.1 → XP_030105285.1  cation channel sperm-associated auxiliary subunit delta isoform X4

      Conserved Domains (1) summary
      pfam15020
      Location:1 → 548
      CATSPERD; Cation channel sperm-associated protein subunit delta

    13. XM_030249423.1 → XP_030105283.1  cation channel sperm-associated auxiliary subunit delta isoform X2

      UniProtKB/TrEMBL
      A0A3B2WD76
      Conserved Domains (1) summary
      pfam15020
      Location:1 → 554
      CATSPERD; Cation channel sperm-associated protein subunit delta

    14. XM_030249427.1 → XP_030105287.1  cation channel sperm-associated auxiliary subunit delta isoform X8

      UniProtKB/TrEMBL
      A0A3B2WD76
      Conserved Domains (1) summary
      pfam15020
      Location:1 → 467
      CATSPERD; Cation channel sperm-associated protein subunit delta

    15. XM_030249426.1 → XP_030105286.1  cation channel sperm-associated auxiliary subunit delta isoform X6

      UniProtKB/TrEMBL
      A0A3B2WD76
      Conserved Domains (1) summary
      pfam15020
      Location:1 → 546
      CATSPERD; Cation channel sperm-associated protein subunit delta

    16. XM_030249430.1 → XP_030105290.1  cation channel sperm-associated auxiliary subunit delta isoform X9

      Conserved Domains (1) summary
      pfam15020
      Location:1 → 592
      CATSPERD; Cation channel sperm-associated protein subunit delta

    17. XM_011246244.2 → XP_011244546.1  cation channel sperm-associated auxiliary subunit delta isoform X13

      UniProtKB/TrEMBL
      A0A3B2WD76
      Related
      ENSMUSP00000156886.2, ENSMUST00000233947.2
      Conserved Domains (1) summary
      pfam15020
      Location:1 → 455
      CATSPERD; Cation channel sperm-associated protein subunit delta
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q9F6.1 GenPept UniProtKB/Swiss-Prot:E9Q9F6

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