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    Stk38 serine/threonine kinase 38 [ Mus musculus (house mouse) ]

    Gene ID: 106504, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Stk38provided by MGI
    Official Full Name
    serine/threonine kinase 38provided by MGI
    Primary source
    MGI:MGI:2442572
    See related
    Ensembl:ENSMUSG00000024006 AllianceGenome:MGI:2442572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ndr1; 5830476G13Rik; 9530097A09Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Predicted to be involved in intracellular signal transduction; negative regulation of MAP kinase activity; and peptidyl-serine phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and nose. Orthologous to human STK38 (serine/threonine kinase 38). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 16.0), thymus adult (RPKM 15.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 15.03 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29189854..29226979, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28970880..29008010, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16191 Neighboring gene peroxisomal, testis specific 1 Neighboring gene STARR-positive B cell enhancer ABC_E9948 Neighboring gene potassium channel tetramerisation domain containing 20 Neighboring gene STARR-positive B cell enhancer ABC_E2477 Neighboring gene predicted gene, 23887 Neighboring gene STARR-seq mESC enhancer starr_42244 Neighboring gene STARR-seq mESC enhancer starr_42246 Neighboring gene predicted gene 16196 Neighboring gene STARR-seq mESC enhancer starr_42249 Neighboring gene serine and arginine-rich splicing factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation. Rawat P, et al. J Biol Chem, 2023 May. PMID 37028764, Free PMC Article
    2. Molecular Mechanism of Biofilm Locator Protein Kinase Dbf2p-related kinase 1 in Regulating Innate Immune Response to Interleukin 17-induced Viral Pneumonia. Wang H, et al. Bioengineered, 2021 Dec. PMID 34699306, Free PMC Article
    3. Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes. Liu J, et al. Sci Rep, 2017 Mar 21. PMID 28322254, Free PMC Article
    4. The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility. Tang F, et al. Sci Signal, 2015 Oct 6. PMID 26443704
    5. Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages. Wen M, et al. Nat Commun, 2015 May 18. PMID 25981615

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation.
      Title: Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation.
    2. Molecular Mechanism of Biofilm Locator Protein Kinase Dbf2p-related kinase 1 in Regulating Innate Immune Response to Interleukin 17-induced Viral Pneumonia.
      Title: Molecular Mechanism of Biofilm Locator Protein Kinase Dbf2p-related kinase 1 in Regulating Innate Immune Response to Interleukin 17-induced Viral Pneumonia.
    3. These results revealed that Stk38 kinase catalyzes the phosphorylation of Rbm24 during sarcomerogensis and this orchestrates accurate sarcomere alignment.
      Title: Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes.
    4. a novel and intimate link between the protein kinase NDR1 and TGFbeta signaling
      Title: Identification of a Novel Link between the Protein Kinase NDR1 and TGFβ Signaling in Epithelial Cells.
    5. Stk38 protein kinase has a role in inhibiting TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages
      Title: Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages.
    6. Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling.
      Title: MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.
    7. reduction in the abundances of the NDR proteins NDR1 and NDR2 results in defective responses to proapoptotic stimuli, thereby facilitating the development of tumors
      Title: Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 38
    Names
    NDR1 protein kinase
    nuclear Dbf2-related kinase 1
    NP_001344102.1
    NP_598876.1
    XP_011244534.1
    XP_011244535.1
    XP_030105270.1
    XP_030105271.1
    XP_036016133.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357173.1 → NP_001344102.1  serine/threonine-protein kinase 38

      Status: VALIDATED

      Source sequence(s)
      AY292399, BE686860, BY750361, CT025867, CX202466
      Consensus CDS
      CCDS28589.1
      UniProtKB/Swiss-Prot
      Q91VJ4
      Related
      ENSMUSP00000113657.2, ENSMUST00000119274.3
      Conserved Domains (1) summary
      cd05628
      Location:87 → 462
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

    2. NM_134115.3 → NP_598876.1  serine/threonine-protein kinase 38

      See identical proteins and their annotated locations for NP_598876.1

      Status: VALIDATED

      Source sequence(s)
      AC167363, BE686860, CT025867
      Consensus CDS
      CCDS28589.1
      UniProtKB/Swiss-Prot
      Q91VJ4
      Related
      ENSMUSP00000009138.6, ENSMUST00000009138.13
      Conserved Domains (1) summary
      cd05628
      Location:87 → 462
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      29189854..29226979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249410.2 → XP_030105270.1  serine/threonine-protein kinase 38 isoform X3

      UniProtKB/TrEMBL
      A0A3B2W7L2
      Conserved Domains (1) summary
      cl21453
      Location:1 → 289
      PKc_like; Protein Kinases, catalytic domain

    2. XM_030249411.1 → XP_030105271.1  serine/threonine-protein kinase 38 isoform X3

      UniProtKB/TrEMBL
      A0A3B2W7L2
      Related
      ENSMUSP00000156592.2, ENSMUST00000141431.8
      Conserved Domains (1) summary
      cl21453
      Location:1 → 289
      PKc_like; Protein Kinases, catalytic domain

    3. XM_011246232.3 → XP_011244534.1  serine/threonine-protein kinase 38 isoform X2

      See identical proteins and their annotated locations for XP_011244534.1

      Conserved Domains (1) summary
      cd05628
      Location:36 → 411
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

    4. XM_011246233.3 → XP_011244535.1  serine/threonine-protein kinase 38 isoform X2

      See identical proteins and their annotated locations for XP_011244535.1

      Conserved Domains (1) summary
      cd05628
      Location:36 → 411
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

    5. XM_036160240.1 → XP_036016133.1  serine/threonine-protein kinase 38 isoform X1

      UniProtKB/Swiss-Prot
      Q91VJ4
      Related
      ENSMUSP00000156711.2, ENSMUST00000232836.2
      Conserved Domains (1) summary
      cd05628
      Location:87 → 462
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

    RNA

    1. XR_004939455.1 RNA Sequence

    2. XR_004939456.1 RNA Sequence

      Related
      ENSMUST00000126893.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VJ4.1 GenPept UniProtKB/Swiss-Prot:Q91VJ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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