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    Ypel1 yippee like 1 [ Mus musculus (house mouse) ]

    Gene ID: 106369, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ypel1provided by MGI
    Official Full Name
    yippee like 1provided by MGI
    Primary source
    MGI:MGI:1913303
    See related
    Ensembl:ENSMUSG00000022773 AllianceGenome:MGI:1913303
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dgl1; DGL-1; Ppil2; mdgl-1; 0610009L05Rik; 1700016N17Rik; 1700019O22Rik; 4921520K19Rik; 4930511F14Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be located in nucleus. Is expressed in several structures, including brain; endocrine gland; genitourinary system; hemolymphoid system gland; and white fat. Orthologous to human YPEL1 (yippee like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 54.8), CNS E18 (RPKM 18.8) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A3; 16 10.58 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16887454..16904912)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17070139..17087048)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6438 Neighboring gene STARR-positive B cell enhancer ABC_E9426 Neighboring gene mitogen-activated protein kinase 1 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 2 Neighboring gene RIKEN cDNA 2610318N02 gene Neighboring gene microRNA 130b Neighboring gene microRNA 301b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ypel1: a novel nuclear protein that induces an epithelial-like morphology in fibroblasts. Farlie P, et al. Genes Cells, 2001 Jul. PMID 11473580
    2. Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Cotter L, et al. Science, 2010 Jun 11. PMID 20448149
    3. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Hosono K, et al. Gene, 2004 Sep 29. PMID 15556292
    4. YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. Hosono K, et al. Genomics, 2010 Aug. PMID 20580816
    5. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. Chiellini C, et al. J Cell Physiol, 2003 May. PMID 12652657

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein yippee-like 1
    Names
    cardiac Abnormality/abnormal facies (CATCH22), microdeletion syndrome

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291047.1 → NP_001277976.1  protein yippee-like 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK006505, AK014931, AK139453, BB610926, BB649357
      UniProtKB/Swiss-Prot
      Q9ESC7
      UniProtKB/TrEMBL
      Q65Z96
      Conserved Domains (1) summary
      cl13152
      Location:96 → 185
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    2. NM_001291053.1 → NP_001277982.1  protein yippee-like 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons in the 5' UTR and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK006505, AK014931, AK139453, BB649357, BQ573264
      UniProtKB/TrEMBL
      Q810N0
      Related
      ENSMUST00000231518.2
      Conserved Domains (1) summary
      cl13152
      Location:13 → 80
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    3. NM_023249.6 → NP_075738.1  protein yippee-like 1 isoform 2

      See identical proteins and their annotated locations for NP_075738.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK006505, AK014931, AK139453, BB649357
      Consensus CDS
      CCDS37268.1
      UniProtKB/Swiss-Prot
      Q9ESC7
      UniProtKB/TrEMBL
      Q65Z96
      Related
      ENSMUSP00000039760.8, ENSMUST00000035682.16
      Conserved Domains (1) summary
      cl13152
      Location:20 → 108
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      16887454..16904912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521679.4 → XP_006521742.1  protein yippee-like 1 isoform X4

      See identical proteins and their annotated locations for XP_006521742.1

      UniProtKB/TrEMBL
      A0A338P6Z8
      Related
      ENSMUSP00000156213.2, ENSMUST00000232574.2

    2. XM_006521681.5 → XP_006521744.1  protein yippee-like 1 isoform X6

    3. XM_006521677.2 → XP_006521740.1  protein yippee-like 1 isoform X3

      UniProtKB/TrEMBL
      Q9DA95

    4. XM_006521675.5 → XP_006521738.1  protein yippee-like 1 isoform X1

      UniProtKB/TrEMBL
      Q9DA95

    5. XM_006521676.5 → XP_006521739.1  protein yippee-like 1 isoform X2

      Conserved Domains (1) summary
      cl13152
      Location:107 → 197
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    6. XM_030248914.1 → XP_030104774.1  protein yippee-like 1 isoform X5

      UniProtKB/Swiss-Prot
      Q9ESC7
      UniProtKB/TrEMBL
      Q65Z96
      Conserved Domains (1) summary
      cl13152
      Location:20 → 108
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    7. XM_006521680.2 → XP_006521743.1  protein yippee-like 1 isoform X4

      See identical proteins and their annotated locations for XP_006521743.1

      UniProtKB/TrEMBL
      A0A338P6Z8
      Conserved Domains (1) summary
      cl13152
      Location:21 → 94
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESC7.1 GenPept UniProtKB/Swiss-Prot:Q9ESC7

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