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    Qtrt2 queuine tRNA-ribosyltransferase accessory subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 106248, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Qtrt2provided by MGI
    Official Full Name
    queuine tRNA-ribosyltransferase accessory subunit 2provided by MGI
    Primary source
    MGI:MGI:1922194
    See related
    Ensembl:ENSMUSG00000022704 AllianceGenome:MGI:1922194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Qrtr2; Qtrtd1; 3110012M05Rik; 4930470H18Rik
    Summary
    Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to contribute to queuine tRNA-ribosyltransferase activity. Involved in tRNA-guanine transglycosylation. Located in mitochondrion. Part of protein-containing complex. Orthologous to human QTRT2 (queuine tRNA-ribosyltransferase accessory subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 12.0), CNS E11.5 (RPKM 10.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B4; 16 28.44 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (43681879..43710063, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (43861407..43889797, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene dopamine receptor D3 Neighboring gene STARR-seq mESC enhancer starr_40887 Neighboring gene predicted gene, 26074 Neighboring gene STARR-seq mESC enhancer starr_40888 Neighboring gene STARR-positive B cell enhancer ABC_E1924 Neighboring gene predicted gene, 25989 Neighboring gene coiled-coil domain containing 191 Neighboring gene STARR-positive B cell enhancer mm9_chr16:43951746-43952047 Neighboring gene zinc finger, DHHC domain containing 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Homodimer Architecture of QTRT2, the Noncatalytic Subunit of the Eukaryotic tRNA-Guanine Transglycosylase. Behrens C, et al. Biochemistry, 2018 Jul 3. PMID 29862811
    2. Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase. Sebastiani M, et al. ACS Chem Biol, 2022 Aug 19. PMID 35815944
    3. Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase. Boland C, et al. J Biol Chem, 2009 Jul 3. PMID 19414587, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
      Title: Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
    2. In the crystal, QTRT2 is clearly present as a homodimer that is strikingly similar to that formed by bacterial TGT. In particular, a cluster of four aromatic residues within the interface of the bacterial TGT, which constitutes a "hot spot" for dimer stability, is present in a similar constellation in QTRT2.
      Title: Homodimer Architecture of QTRT2, the Noncatalytic Subunit of the Eukaryotic tRNA-Guanine Transglycosylase.
    3. TGT weakly interacts with the outer mitochondrial membrane possibly through association with Qv1(QTRD1 variant 1), which was found to be stably associated with the organelle
      Title: Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102598

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pentosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-guanine transglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA-guanine transglycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA-guanine transglycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    queuine tRNA-ribosyltransferase accessory subunit 2
    Names
    queuine tRNA-ribosyltransferase domain containing 1
    queuine tRNA-ribosyltransferase domain-containing protein 1
    queuine tRNA-ribosyltransferase subunit QTRTD1
    NP_001343257.1
    NP_001343258.2
    NP_001392345.1
    NP_001392346.1
    NP_001392347.1
    NP_083404.3
    XP_006521733.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356328.2 → NP_001343257.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025520
      Conserved Domains (1) summary
      pfam01702
      Location:48 → 322
      TGT; Queuine tRNA-ribosyltransferase

    2. NM_001356329.4 → NP_001343258.2  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT025520
      Consensus CDS
      CCDS88930.1
      UniProtKB/Swiss-Prot
      A9C446, B8ZXI1, Q5XK35
      Related
      ENSMUSP00000158885.2, ENSMUST00000239112.2

    3. NM_001405416.1 → NP_001392345.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025520

    4. NM_001405417.1 → NP_001392346.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025520

    5. NM_001405418.1 → NP_001392347.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025520

    6. NM_029128.5 → NP_083404.3  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT025520
      Consensus CDS
      CCDS37344.1
      Related
      ENSMUSP00000023387.8, ENSMUST00000023387.14

    RNA

    1. NR_175937.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT025520
      Related
      ENSMUST00000156568.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      43681879..43710063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521670.5 → XP_006521733.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X2

      See identical proteins and their annotated locations for XP_006521733.1

      UniProtKB/TrEMBL
      A0A5F8MPN7, Z4YJE9
      Conserved Domains (1) summary
      pfam01702
      Location:14 → 416
      TGT; Queuine tRNA-ribosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B8ZXI1.2 GenPept UniProtKB/Swiss-Prot:B8ZXI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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