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    Zc3h7a zinc finger CCCH type containing 7 A [ Mus musculus (house mouse) ]

    Gene ID: 106205, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zc3h7aprovided by MGI
    Official Full Name
    zinc finger CCCH type containing 7 Aprovided by MGI
    Primary source
    MGI:MGI:2445044
    See related
    Ensembl:ENSMUSG00000037965 AllianceGenome:MGI:2445044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zc3h7; HSPC055; Zc3hdc7; A430104C18Rik
    Summary
    Predicted to enable miRNA binding activity. Predicted to be involved in production of miRNAs involved in gene silencing by miRNA. Is expressed in Meckel's cartilage; embryo mesenchyme; and skeleton. Orthologous to human ZC3H7A (zinc finger CCCH-type containing 7A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 21.0), limb E14.5 (RPKM 20.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A1; 16 6.35 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10954458..10994257, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (11136594..11176393, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9861 Neighboring gene STARR-positive B cell enhancer ABC_E9926 Neighboring gene STARR-positive B cell enhancer ABC_E10889 Neighboring gene nonconserved acetylation island sequence M94 enhancer Neighboring gene stannin Neighboring gene thioredoxin domain containing 11 Neighboring gene RIKEN cDNA 4930509G22 gene Neighboring gene predicted gene, 24145 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene Wdr45 like pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation. Liang J, et al. PLoS One, 2008 Aug 6. PMID 18682727, Free PMC Article
    2. Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. Timmermans S, et al. JCI Insight, 2018 Jul 12. PMID 29997285, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 7A
    Names
    zinc finger CCCH type domain containing 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145931.3 → NP_666043.2  zinc finger CCCH domain-containing protein 7A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AK040507, AK150952, AV228180
      Consensus CDS
      CCDS49762.1
      UniProtKB/TrEMBL
      E9PWW6, Q3UBH9
      Related
      ENSMUSP00000041308.10, ENSMUST00000037633.16
      Conserved Domains (4) summary
      TIGR00990
      Location:6 → 169
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00020
      Location:858 → 880
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:46 → 71
      TPR; TPR repeat [structural motif]
      pfam12171
      Location:856 → 881
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    RNA

    1. NR_027502.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK040507, AK150952, BY297607, CJ302186

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      10954458..10994257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521665.4 → XP_006521728.2  zinc finger CCCH domain-containing protein 7A isoform X1

      UniProtKB/TrEMBL
      E9PWW6, Q3UBH9
      Conserved Domains (4) summary
      TIGR00990
      Location:6 → 169
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00020
      Location:858 → 880
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:46 → 71
      TPR; TPR repeat [structural motif]
      pfam12171
      Location:856 → 881
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    2. XM_006521664.4 → XP_006521727.2  zinc finger CCCH domain-containing protein 7A isoform X1

      UniProtKB/TrEMBL
      E9PWW6, Q3UBH9
      Conserved Domains (4) summary
      TIGR00990
      Location:6 → 169
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00020
      Location:858 → 880
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:46 → 71
      TPR; TPR repeat [structural motif]
      pfam12171
      Location:856 → 881
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    3. XM_006521666.3 → XP_006521729.2  zinc finger CCCH domain-containing protein 7A isoform X1

      UniProtKB/TrEMBL
      E9PWW6, Q3UBH9
      Conserved Domains (4) summary
      TIGR00990
      Location:6 → 169
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00020
      Location:858 → 880
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00006
      Location:46 → 71
      TPR; TPR repeat [structural motif]
      pfam12171
      Location:856 → 881
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    RNA

    1. XR_004939142.1 RNA Sequence

    2. XR_004939143.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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