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    Txndc11 thioredoxin domain containing 11 [ Mus musculus (house mouse) ]

    Gene ID: 106200, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Txndc11provided by MGI
    Official Full Name
    thioredoxin domain containing 11provided by MGI
    Primary source
    MGI:MGI:1923620
    See related
    Ensembl:ENSMUSG00000022498 AllianceGenome:MGI:1923620
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EFP1; Txdc11; 2810408E11Rik
    Summary
    Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Orthologous to human TXNDC11 (thioredoxin domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 30.3), mammary gland adult (RPKM 28.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A1; 16 6.33 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10892775..10952541, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (11074911..11134645, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 15 pseudogene Neighboring gene predicted gene 9861 Neighboring gene STARR-positive B cell enhancer ABC_E9926 Neighboring gene STARR-positive B cell enhancer ABC_E10889 Neighboring gene nonconserved acetylation island sequence M94 enhancer Neighboring gene stannin Neighboring gene zinc finger CCCH type containing 7 A Neighboring gene RIKEN cDNA 4930509G22 gene Neighboring gene predicted gene, 24145 Neighboring gene 40S ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of diabetes susceptibility loci in db mice by combined quantitative trait loci analysis and haplotype mapping. Moritani M, et al. Genomics, 2006 Dec. PMID 16919419
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin domain-containing protein 11
    Names
    EF-hand binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029582.2 → NP_083858.1  thioredoxin domain-containing protein 11 isoform 1

      See identical proteins and their annotated locations for NP_083858.1

      Status: PROVISIONAL

      Source sequence(s)
      AC087541, AC164093
      Consensus CDS
      CCDS27960.1
      UniProtKB/Swiss-Prot
      Q8BMR8, Q8K2W3, Q8VCK9
      UniProtKB/TrEMBL
      Q3U194
      Related
      ENSMUSP00000041113.8, ENSMUST00000038424.14
      Conserved Domains (5) summary
      cd02981
      Location:215 → 319
      PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02995
      Location:661 → 763
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03006
      Location:93 → 205
      PDI_a_EFP1_N; PDIa family, N-terminal EFP1 subfamily; EFP1 is a binding partner protein of thyroid oxidase (ThOX), also called Duox. ThOX proteins are responsible for the generation of hydrogen peroxide, a crucial substrate of thyroperoxidase, which functions to ...
      pfam08287
      Location:800 → 872
      DASH_Spc19; Spc19
      pfam13848
      Location:254 → 397
      Thioredoxin_6; Thioredoxin-like domain

    2. NM_134105.2 → NP_598866.1  thioredoxin domain-containing protein 11 isoform 2

      See identical proteins and their annotated locations for NP_598866.1

      Status: PROVISIONAL

      Source sequence(s)
      BC019564
      UniProtKB/Swiss-Prot
      Q8K2W3
      Conserved Domains (2) summary
      cd02995
      Location:37 → 139
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      pfam08287
      Location:176 → 248
      DASH_Spc19; Spc19

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      10892775..10952541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159724.1 → XP_036015617.1  thioredoxin domain-containing protein 11 isoform X4

      Conserved Domains (3) summary
      COG4942
      Location:485 → 569
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd02995
      Location:357 → 459
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      PTZ00102
      Location:200 → 463
      PTZ00102; disulphide isomerase; Provisional

    2. XM_006521659.4 → XP_006521722.1  thioredoxin domain-containing protein 11 isoform X1

      UniProtKB/TrEMBL
      Q3U194
      Conserved Domains (4) summary
      COG4942
      Location:720 → 804
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd02995
      Location:592 → 694
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03006
      Location:93 → 205
      PDI_a_EFP1_N; PDIa family, N-terminal EFP1 subfamily; EFP1 is a binding partner protein of thyroid oxidase (ThOX), also called Duox. ThOX proteins are responsible for the generation of hydrogen peroxide, a crucial substrate of thyroperoxidase, which functions to ...
      PTZ00102
      Location:435 → 698
      PTZ00102; disulphide isomerase; Provisional

    3. XM_030248911.2 → XP_030104771.1  thioredoxin domain-containing protein 11 isoform X4

      Conserved Domains (3) summary
      COG4942
      Location:485 → 569
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd02995
      Location:357 → 459
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      PTZ00102
      Location:200 → 463
      PTZ00102; disulphide isomerase; Provisional

    4. XM_006521660.5 → XP_006521723.1  thioredoxin domain-containing protein 11 isoform X2

      UniProtKB/TrEMBL
      Q3U194
      Conserved Domains (5) summary
      COG4942
      Location:714 → 798
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd02995
      Location:586 → 688
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      PTZ00102
      Location:429 → 692
      PTZ00102; disulphide isomerase; Provisional
      pfam13848
      Location:166 → 322
      Thioredoxin_6; Thioredoxin-like domain
      cl00388
      Location:76 → 130
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    5. XM_006521661.5 → XP_006521724.1  thioredoxin domain-containing protein 11 isoform X3

      See identical proteins and their annotated locations for XP_006521724.1

      Conserved Domains (4) summary
      COG4942
      Location:579 → 663
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd02995
      Location:451 → 553
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      PTZ00102
      Location:294 → 557
      PTZ00102; disulphide isomerase; Provisional
      pfam13848
      Location:31 → 187
      Thioredoxin_6; Thioredoxin-like domain

    6. XM_036159723.1 → XP_036015616.1  thioredoxin domain-containing protein 11 isoform X4

      Conserved Domains (3) summary
      COG4942
      Location:485 → 569
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd02995
      Location:357 → 459
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      PTZ00102
      Location:200 → 463
      PTZ00102; disulphide isomerase; Provisional

    7. XM_006521662.4 → XP_006521725.1  thioredoxin domain-containing protein 11 isoform X3

      See identical proteins and their annotated locations for XP_006521725.1

      Conserved Domains (4) summary
      COG4942
      Location:579 → 663
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd02995
      Location:451 → 553
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      PTZ00102
      Location:294 → 557
      PTZ00102; disulphide isomerase; Provisional
      pfam13848
      Location:31 → 187
      Thioredoxin_6; Thioredoxin-like domain

    8. XM_036159725.1 → XP_036015618.1  thioredoxin domain-containing protein 11 isoform X4

      Conserved Domains (3) summary
      COG4942
      Location:485 → 569
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd02995
      Location:357 → 459
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      PTZ00102
      Location:200 → 463
      PTZ00102; disulphide isomerase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2W3.1 GenPept UniProtKB/Swiss-Prot:Q8K2W3

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