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    Tafa5 TAFA chemokine like family member 5 [ Mus musculus (house mouse) ]

    Gene ID: 106014, updated on 11-Apr-2024

    Summary

    Official Symbol
    Tafa5provided by MGI
    Official Full Name
    TAFA chemokine like family member 5provided by MGI
    Primary source
    MGI:MGI:2146182
    See related
    Ensembl:ENSMUSG00000054863 AllianceGenome:MGI:2146182
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tafa-5; Tara-5; Fam19a5
    Summary
    This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Biased expression in frontal lobe adult (RPKM 18.4), cerebellum adult (RPKM 17.8) and 14 other tissues See more
    Orthologs
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    Genomic context

    Location:
    15 E3; 15 42.1 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (87428405..87643565)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (87544219..87759364)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39425 Neighboring gene predicted gene, 35422 Neighboring gene predicted gene, 35471 Neighboring gene STARR-seq mESC enhancer starr_39426 Neighboring gene STARR-seq mESC enhancer starr_39427 Neighboring gene microRNA 6393 Neighboring gene predicted gene, 35599 Neighboring gene predicted gene, 35711

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    chemokine-like protein TAFA-5
    Names
    family with sequence similarity 19, member A5
    protein FAM19A5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252310.1NP_001239239.1  chemokine-like protein TAFA-5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001239239.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC123925, AK090194, BE945208, BU057253, BY733542
      Consensus CDS
      CCDS88823.1
      UniProtKB/Swiss-Prot
      Q8C1V6, Q91WE9
      Related
      ENSMUSP00000155322.2, ENSMUST00000230414.2
      Conserved Domains (1) summary
      pfam12020
      Location:42131
      TAFA; TAFA family
    2. NM_134096.2NP_598857.1  chemokine-like protein TAFA-5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_598857.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC123925, AY325124, BE945208
      Consensus CDS
      CCDS49693.1
      UniProtKB/Swiss-Prot
      Q91WE9
      Related
      ENSMUSP00000064808.7, ENSMUST00000068088.8
      Conserved Domains (1) summary
      pfam12020
      Location:35124
      TAFA; TAFA family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      87428405..87643565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520262.3XP_006520325.1  chemokine-like protein TAFA-5 isoform X3

      Conserved Domains (1) summary
      pfam12020
      Location:4290
      TAFA; TAFA family
    2. XM_006520260.4XP_006520323.1  chemokine-like protein TAFA-5 isoform X1

      Conserved Domains (1) summary
      pfam12020
      Location:42131
      TAFA; TAFA family
    3. XM_006520261.4XP_006520324.1  chemokine-like protein TAFA-5 isoform X2

      Conserved Domains (1) summary
      pfam12020
      Location:35124
      TAFA; TAFA family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_045510.1: Suppressed sequence

      Description
      NR_045510.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.