Scrib scribbled planar cell polarity [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scribprovided by MGI
Official Full Name: scribbled planar cell polarityprovided by MGI
Primary source: MGI:MGI:2145950
See related: Ensembl:ENSMUSG00000022568 AllianceGenome:MGI:2145950
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crc; CRIB; Scrb1; SCRIB1; vartul; mKIAA0147
Summary: Involved in several processes, including establishment of T cell polarity; negative regulation of activated T cell proliferation; and synaptic vesicle cycle. Acts upstream of or within several processes, including nervous system development; post-anal tail morphogenesis; and wound healing. Located in several cellular components, including basolateral plasma membrane; immunological synapse; and myelin sheath abaxonal region. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; hair follicle; and nervous system. Orthologous to human SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 45.6), thymus adult (RPKM 36.9) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 15 D3; 15 35.29 cM

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (75919011..75941633, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (76047162..76069784, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Early loss of Scribble affects cortical development, interhemispheric connectivity and psychomotor activity.
Title: Early loss of Scribble affects cortical development, interhemispheric connectivity and psychomotor activity.
Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure.
Title: Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure.
Scribble promotes alveologenesis in the pregnant mammary gland for milk production.
Title: Scribble promotes alveologenesis in the pregnant mammary gland for milk production.
Low SCRIB expression in fibroblasts promotes invasion of lung cancer cells.
Title: Low SCRIB expression in fibroblasts promotes invasion of lung cancer cells.
By maintaining a quiescent endothelial phenotype, the polarity protein Scrib elicits anti-atherosclerotic functions.
Title: The polarity protein Scrib limits atherosclerosis development in mice.
Uterine deletion of Scrib leads to defective primary decidual zone (PDZ) formation and implantation chamber (crypt) formation, compromising pregnancy success. Interestingly, epithelial-specific Scrib deletion does not adversely affect PDZ formation and pregnancy success.
Title: Primary decidual zone formation requires Scribble for pregnancy success in mice.
Scribble deficiency reduces surface expression of Epo receptor but selectively retains survival signaling via Akt.
Title: Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.
Scribdeficient hematopoietic stem cells reveal impaired migratory capacity.
Title: Diverging impact of cell fate determinants Scrib and Llgl1 on adhesion and migration of hematopoietic stem cells.
Results identify a key planar cell polarity (PCP) protein, Scrib, as one of the fundamental scaffold proteins that enable hippocampal glutamatergic synapses to mature and to express bidirectional plasticity required for memory formation. Study offers a unique insight into the mechanism by which the PCP protein Scrib can regulate memory formation at postnatal stages.
Title: Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse.
In the Scrib mutant, despite severe neural tube defects, epF and preBotC neurons settled at their expected hindbrain positions. Furthermore, both networks remained capable of generating rhythmically organized, respiratory-related activities and exhibited normal sensitivity to pharmacological agents known to modify respiratory circuit function.
Title: The embryonic development of hindbrain respiratory networks is unaffected by mutation of the planar polarity protein Scribble.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation
Targeted (9) 1 citation
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH25368 (e-PCR)
- UniSTS:5249

AI118201 (e-PCR)
- UniSTS:160464

STS-H95077 (e-PCR)
- UniSTS:32983

RH141209 (e-PCR)
- UniSTS:223205

Rbm16 (e-PCR), detects polymorphism
- UniSTS:479224

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process involved in morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in astrocyte cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within auditory receptor cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within auditory receptor cell stereocilium organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in camera-type eye morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cochlear nucleus development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in establishment of T cell polarity	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of apical/basal cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mammary gland duct morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
involved_in polarized epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to adherens junction	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle targeting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport in synapse	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Scrib-APC-beta-catenin complex	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in apical plasma membrane	TAS Traceable Author Statement more info	PubMed
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
colocalizes_with cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell-cell contact zone	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in extrinsic component of postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in myelin sheath abaxonal region	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
colocalizes_with postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: protein scribble homolog

Names: PDZ-domain protein scribble; circletail; scribble homolog 1; scribbled homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310542.1 → NP_001297471.1 protein scribble homolog isoform 2

See identical proteins and their annotated locations for NP_001297471.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon in the 3' region compared to variant 1. The resulting isoform (2) is shorter, missing an internal protein segment compared to isoform 1.

Source sequence(s)

AK122211, BC062888

Consensus CDS

CCDS79382.1

UniProtKB/Swiss-Prot

Q80U72

Related

ENSMUSP00000105572.3, ENSMUST00000109946.9

Conserved Domains (7) summary

smart00228
Location:711 → 799

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:12 → 232

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:988 → 1076

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:289 → 329

LRR_4; Leucine Rich repeats (2 copies)

pfam16182
Location:1537 → 1631

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001310543.1 → NP_001297472.1 protein scribble homolog isoform 3

See identical proteins and their annotated locations for NP_001297472.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two in-frame coding exons in the 3' region compared to variant 1. The resulting isoform (3) is shorter, missing two internal protein segments compared to isoform 1.

Source sequence(s)

AK122211, BC062888

Consensus CDS

CCDS79381.1

UniProtKB/Swiss-Prot

Q6P5H7, Q7TPH8, Q80U72, Q80VB1, Q8CI48, Q8VII1, Q922S3

Related

ENSMUSP00000068056.6, ENSMUST00000063747.12

Conserved Domains (4) summary

smart00228
Location:711 → 799

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:988 → 1076

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
NM_134089.2 → NP_598850.1 protein scribble homolog isoform 1

See identical proteins and their annotated locations for NP_598850.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AF441233, AK122211, BC062888

Consensus CDS

CCDS27560.1

UniProtKB/Swiss-Prot

Q80U72

Related

ENSMUSP00000002603.6, ENSMUST00000002603.12

Conserved Domains (7) summary

smart00228
Location:711 → 799

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:12 → 232

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:988 → 1076

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:289 → 329

LRR_4; Leucine Rich repeats (2 copies)

pfam16182
Location:1565 → 1659

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

75919011..75941633 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248260.1 → XP_030104120.1 protein scribble homolog isoform X6

Conserved Domains (4) summary

smart00228
Location:160 → 248

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PRK14971
Location:722 → 854

PRK14971; DNA polymerase III subunit gamma/tau

cd00992
Location:437 → 525

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16182
Location:1017 → 1108

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_006520242.3 → XP_006520305.1 protein scribble homolog isoform X5

Conserved Domains (6) summary

smart00228
Location:484 → 572

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 164

LRR; Leucine-rich repeat (LRR) protein [Transcription]

PRK14971
Location:1046 → 1178

PRK14971; DNA polymerase III subunit gamma/tau

cd00992
Location:761 → 849

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:41 → 63

LRR_RI; leucine-rich repeat [structural motif]

pfam16182
Location:1341 → 1432

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_006520238.4 → XP_006520301.1 protein scribble homolog isoform X1

Conserved Domains (6) summary

smart00228
Location:710 → 798

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:987 → 1075

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam15449
Location:1217 → 1361

Retinal; Retinal protein

pfam16182
Location:1567 → 1658

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_017316355.3 → XP_017171844.1 protein scribble homolog isoform X4

UniProtKB/Swiss-Prot

Q80U72

Conserved Domains (5) summary

smart00228
Location:693 → 778

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

PRK14971
Location:1252 → 1384

PRK14971; DNA polymerase III subunit gamma/tau

cd00992
Location:967 → 1055

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
XM_006520239.5 → XP_006520302.1 protein scribble homolog isoform X2

Conserved Domains (6) summary

smart00228
Location:693 → 778

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

PRK14971
Location:1252 → 1384

PRK14971; DNA polymerase III subunit gamma/tau

cd00992
Location:967 → 1055

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam16182
Location:1547 → 1638

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_017316354.3 → XP_017171843.1 protein scribble homolog isoform X3

Conserved Domains (5) summary

smart00228
Location:711 → 799

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG4886
Location:39 → 405

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:988 → 1076

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam15449
Location:1218 → 1362

Retinal; Retinal protein