Rcbtb2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rcbtb2provided by MGI
Official Full Name: regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2provided by MGI
Primary source: MGI:MGI:1917200
See related: Ensembl:ENSMUSG00000022106 AllianceGenome:MGI:1917200
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Chc1l; RC/BTB2; 2610028E02Rik; 2810420M18Rik
Summary: Located in acrosomal vesicle. Used to study malignant histiocytic disease. Orthologous to human RCBTB2 (RCC1 and BTB domain containing protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 22.6), CNS E11.5 (RPKM 17.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 38.66 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (73376185..73421495)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (73138745..73184055)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings suggest that RC/BTB2 is a necessary component of the process of formation of primary cilia in somatic cells, perhaps through the transportation of cargos from Golgi bodies to centrosomes for cilia assembling.
Title: RC/BTB2 is essential for formation of primary cilia in mammalian cells.
The expression and localization of mouse RC/BTB2 in the testis and male germ cells, was characterized.
Title: Mouse RC/BTB2, a member of the RCC1 superfamily, localizes to spermatid acrosomal vesicles.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI448345 (e-PCR)
- UniSTS:165915

AW240694 (e-PCR)
- UniSTS:180695

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymph node development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RCC1 and BTB domain-containing protein 2

Names: regulator of chromosome condensation and BTB domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170694.1 → NP_001164165.1 RCC1 and BTB domain-containing protein 2

See identical proteins and their annotated locations for NP_001164165.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AA119207, AK031248, AK160881, CX209814

Consensus CDS

CCDS27266.1

UniProtKB/Swiss-Prot

G1EE51, Q3TUA3, Q8BMG2, Q99LJ7

UniProtKB/TrEMBL

E9Q3B1

Related

ENSMUSP00000131588.2, ENSMUST00000164822.8

Conserved Domains (3) summary

COG5184
Location:107 → 335

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:374 → 490

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:487 → 551

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
NM_134083.4 → NP_598844.3 RCC1 and BTB domain-containing protein 2

See identical proteins and their annotated locations for NP_598844.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AA119207, AK031242, AK160881, CX209814

Consensus CDS

CCDS27266.1

UniProtKB/Swiss-Prot

G1EE51, Q3TUA3, Q8BMG2, Q99LJ7

UniProtKB/TrEMBL

E9Q3B1

Related

ENSMUSP00000022702.7, ENSMUST00000022702.13

Conserved Domains (3) summary

COG5184
Location:107 → 335

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:374 → 490

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:487 → 551

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

RNA

NR_033185.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

CT571265

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

73376185..73421495

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518384.2 → XP_006518447.1 RCC1 and BTB domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006518447.1

UniProtKB/Swiss-Prot

G1EE51, Q3TUA3, Q8BMG2, Q99LJ7

UniProtKB/TrEMBL

E9Q3B1

Conserved Domains (3) summary

COG5184
Location:107 → 335

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:374 → 490

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:487 → 551

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
XM_006518386.3 → XP_006518449.1 RCC1 and BTB domain-containing protein 2 isoform X2

See identical proteins and their annotated locations for XP_006518449.1

UniProtKB/TrEMBL

E9Q3B1

Conserved Domains (3) summary

COG5184
Location:83 → 311

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:350 → 466

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:463 → 527

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
XM_006518388.3 → XP_006518451.1 RCC1 and BTB domain-containing protein 2 isoform X4

Conserved Domains (3) summary

COG5184
Location:13 → 175

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:214 → 330

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:327 → 391

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
XM_011244891.4 → XP_011243193.1 RCC1 and BTB domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_011243193.1

UniProtKB/Swiss-Prot

G1EE51, Q3TUA3, Q8BMG2, Q99LJ7

UniProtKB/TrEMBL

E9Q3B1

Conserved Domains (3) summary

COG5184
Location:107 → 335

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:374 → 490

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:487 → 551

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
XM_036158375.1 → XP_036014268.1 RCC1 and BTB domain-containing protein 2 isoform X4

Conserved Domains (3) summary

COG5184
Location:13 → 175

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:214 → 330

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:327 → 391

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
XM_036158377.1 → XP_036014270.1 RCC1 and BTB domain-containing protein 2 isoform X5

Conserved Domains (2) summary

COG5184
Location:13 → 175

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cl38908
Location:214 → 303

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_030247592.2 → XP_030103452.1 RCC1 and BTB domain-containing protein 2 isoform X3

UniProtKB/TrEMBL

E9Q3B1

Conserved Domains (2) summary

COG5184
Location:107 → 335

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cl38908
Location:374 → 463

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_011244892.4 → XP_011243194.1 RCC1 and BTB domain-containing protein 2 isoform X3

UniProtKB/TrEMBL

E9Q3B1

Conserved Domains (2) summary

COG5184
Location:107 → 335

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cl38908
Location:374 → 463

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_006518382.4 → XP_006518445.1 RCC1 and BTB domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006518445.1

UniProtKB/Swiss-Prot

G1EE51, Q3TUA3, Q8BMG2, Q99LJ7

UniProtKB/TrEMBL

E9Q3B1

Related

ENSMUSP00000127397.2, ENSMUST00000171767.8

Conserved Domains (3) summary

COG5184
Location:107 → 335

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:374 → 490

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:487 → 551

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
XM_030247593.1 → XP_030103453.1 RCC1 and BTB domain-containing protein 2 isoform X4

Conserved Domains (3) summary

COG5184
Location:13 → 175

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:214 → 330

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:327 → 391

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
XM_036158373.1 → XP_036014266.1 RCC1 and BTB domain-containing protein 2 isoform X1

UniProtKB/Swiss-Prot

G1EE51, Q3TUA3, Q8BMG2, Q99LJ7

UniProtKB/TrEMBL

E9Q3B1

Conserved Domains (3) summary

COG5184
Location:107 → 335

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:374 → 490

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:487 → 551

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
XM_036158376.1 → XP_036014269.1 RCC1 and BTB domain-containing protein 2 isoform X5

Conserved Domains (2) summary

COG5184
Location:13 → 175

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cl38908
Location:214 → 303

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_036158374.1 → XP_036014267.1 RCC1 and BTB domain-containing protein 2 isoform X4

Conserved Domains (3) summary

COG5184
Location:13 → 175

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:214 → 330

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:327 → 391

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
XM_030247591.2 → XP_030103451.1 RCC1 and BTB domain-containing protein 2 isoform X2

UniProtKB/TrEMBL

E9Q3B1

Related

ENSMUSP00000128579.2, ENSMUST00000169513.8

Conserved Domains (3) summary

COG5184
Location:83 → 311

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:350 → 466

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:463 → 527

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
XM_006518385.4 → XP_006518448.1 RCC1 and BTB domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006518448.1

UniProtKB/Swiss-Prot

G1EE51, Q3TUA3, Q8BMG2, Q99LJ7

UniProtKB/TrEMBL

E9Q3B1

Conserved Domains (3) summary

COG5184
Location:107 → 335

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:374 → 490

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:487 → 551

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
XM_030247595.2 → XP_030103455.1 RCC1 and BTB domain-containing protein 2 isoform X4

Conserved Domains (3) summary

COG5184
Location:13 → 175

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:214 → 330

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:327 → 391

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
XM_006518383.4 → XP_006518446.1 RCC1 and BTB domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006518446.1

UniProtKB/Swiss-Prot

G1EE51, Q3TUA3, Q8BMG2, Q99LJ7

UniProtKB/TrEMBL

E9Q3B1

Related

ENSMUSP00000106577.4, ENSMUST00000110952.10

Conserved Domains (3) summary

COG5184
Location:107 → 335

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:374 → 490

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:487 → 551

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
XM_030247594.2 → XP_030103454.1 RCC1 and BTB domain-containing protein 2 isoform X4

Conserved Domains (3) summary

COG5184
Location:13 → 175

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cd18354
Location:214 → 330

BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

cd18529
Location:327 → 391

BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)