Fam170b family with sequence similarity 170, member B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fam170bprovided by MGI
Official Full Name: family with sequence similarity 170, member Bprovided by MGI
Primary source: MGI:MGI:2145650
See related: Ensembl:ENSMUSG00000078127 AllianceGenome:MGI:2145650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4922501K12Rik
Summary: Involved in positive regulation of acrosome reaction and regulation of fertilization. Located in outer acrosomal membrane. Orthologous to human FAM170B (family with sequence similarity 170 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 81.1) See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 19.4 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (32555938..32558746)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (32833962..32836789)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the expression and function for the endogenous acrosomal protein FAM170B during spermiogenesis and fertilization
Title: FAM170B, a novel acrosomal protein involved in fertilization in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Markers

AI449756 (e-PCR)
- UniSTS:165900

NoName (e-PCR)
- UniSTS:487617

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of acrosome reaction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fertilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in outer acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein FAM170B

Names: acrosome-related protein; putative protein FAM170B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.