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    Gmpr2 guanosine monophosphate reductase 2 [ Mus musculus (house mouse) ]

    Gene ID: 105446, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gmpr2provided by MGI
    Official Full Name
    guanosine monophosphate reductase 2provided by MGI
    Primary source
    MGI:MGI:1917903
    See related
    Ensembl:ENSMUSG00000002326 AllianceGenome:MGI:1917903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GMPR 2; 1810008P16Rik; 5730544D12Rik
    Summary
    Predicted to enable GMP reductase activity. Predicted to be involved in IMP salvage. Predicted to act upstream of or within GMP catabolic process and monocyte differentiation. Predicted to be part of GMP reductase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human GMPR2 (guanosine monophosphate reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 13.5), thymus adult (RPKM 12.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gmpr2 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55909692..55935602)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55672235..55687861)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene magnesium-dependent phosphatase 1 Neighboring gene neural precursor cell expressed, developmentally down-regulated gene 8 Neighboring gene Terf1 (TRF1)-interacting nuclear factor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56300752-56300861 Neighboring gene predicted gene, 25887 Neighboring gene transglutaminase 1, K polypeptide Neighboring gene STARR-seq mESC enhancer starr_36777 Neighboring gene Rab geranylgeranyl transferase, a subunit Neighboring gene STARR-positive B cell enhancer ABC_E7317

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells. Zhang J, et al. J Cancer Res Clin Oncol, 2003 Feb. PMID 12669231
    2. NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties. Deng Y, et al. Int J Biochem Cell Biol, 2002 Sep. PMID 12009299
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GMP reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within GMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in IMP salvage TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GMP reductase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GMP reductase 2
    Names
    guanosine 5'-monophosphate oxidoreductase 2
    NP_818773.1
    XP_006518429.1
    XP_011243184.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177992.2 → NP_818773.1  GMP reductase 2

      See identical proteins and their annotated locations for NP_818773.1

      Status: VALIDATED

      Source sequence(s)
      AK075772, BE956837, BY099107
      Consensus CDS
      CCDS27124.1
      UniProtKB/Swiss-Prot
      Q542X2, Q8R1T5, Q99L27
      Related
      ENSMUSP00000002397.6, ENSMUST00000002397.7
      Conserved Domains (1) summary
      PRK05096
      Location:3 → 346
      PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55909692..55935602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244882.4 → XP_011243184.1  GMP reductase 2 isoform X2

      Conserved Domains (1) summary
      PRK05096
      Location:3 → 286
      PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional

    2. XM_006518366.3 → XP_006518429.1  GMP reductase 2 isoform X1

      See identical proteins and their annotated locations for XP_006518429.1

      UniProtKB/Swiss-Prot
      Q542X2, Q8R1T5, Q99L27
      Conserved Domains (1) summary
      PRK05096
      Location:3 → 346
      PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99L27.2 GenPept UniProtKB/Swiss-Prot:Q99L27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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