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    Utp15 UTP15 small subunit processome component [ Mus musculus (house mouse) ]

    Gene ID: 105372, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Utp15provided by MGI
    Official Full Name
    UTP15 small subunit processome componentprovided by MGI
    Primary source
    MGI:MGI:2145443
    See related
    Ensembl:ENSMUSG00000041747 AllianceGenome:MGI:2145443
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and rRNA processing. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in endoplasmic reticulum and fibrillar center. Predicted to be active in nucleolus. Orthologous to human UTP15 (UTP15 small subunit processome component). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.4), placenta adult (RPKM 5.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 D1; 13 51.87 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (98383353..98399500, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (98246845..98262992, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 28 Neighboring gene predicted gene, 57601 Neighboring gene STARR-seq mESC enhancer starr_35412 Neighboring gene predicted gene, 34469 Neighboring gene STARR-seq mESC enhancer starr_35415 Neighboring gene STARR-positive B cell enhancer ABC_E5411 Neighboring gene ankyrin repeat family A member 2 Neighboring gene STARR-seq mESC enhancer starr_35417 Neighboring gene predicted gene 21976

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    2. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    3. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in positive regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U3 small nucleolar RNA-associated protein 15 homolog
    Names
    UTP15, U3 small nucleolar ribonucleoprotein, homolog
    src-associated protein SAW

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178918.3 → NP_849249.1  U3 small nucleolar RNA-associated protein 15 homolog

      See identical proteins and their annotated locations for NP_849249.1

      Status: PROVISIONAL

      Source sequence(s)
      AC123056
      Consensus CDS
      CCDS26712.1
      UniProtKB/Swiss-Prot
      Q3TRG8, Q8C7V3, Q8K231
      UniProtKB/TrEMBL
      Q3TN42
      Related
      ENSMUSP00000048204.3, ENSMUST00000040972.4
      Conserved Domains (4) summary
      COG2319
      Location:28 → 310
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:39 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam09384
      Location:343 → 487
      UTP15_C; UTP15 C terminal
      sd00039
      Location:41 → 78
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      98383353..98399500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C7V3.1 GenPept UniProtKB/Swiss-Prot:Q8C7V3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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