Epdr1 ependymin related 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Epdr1provided by MGI
Official Full Name: ependymin related 1provided by MGI
Primary source: MGI:MGI:2145369
See related: Ensembl:ENSMUSG00000002808 AllianceGenome:MGI:2145369
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ucc1; Epdm2; Epdr2; MERP2; MERP-1; MERP-2
Summary: Predicted to enable ganglioside GM1 binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in myofibroblast contraction. Located in lysosome. Is expressed in brain; cranial ganglion; jaw bone; and ventricular layer. Orthologous to human EPDR1 (ependymin related 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 31.0), ovary adult (RPKM 26.0) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A2; 13 6.97 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (19775878..19804000, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (19591708..19619830, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EPDR1 is a noncanonical effector of insulin-mediated angiogenesis regulated by an endothelial-specific TGF-beta receptor complex.
Title: EPDR1 is a noncanonical effector of insulin-mediated angiogenesis regulated by an endothelial-specific TGF-β receptor complex.
A novel density shift method was used to demonstrate that EPDR resides in the lysosome.
Title: Demonstration of lysosomal localization for the mammalian ependymin-related protein using classical approaches combined with a novel density shift method.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables ganglioside GM1 binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in myofibroblast contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mammalian ependymin-related protein 1

Names: ependymin 2; ependymin related protein 1; ependymin related protein 2; upregulated in colorectal cancer gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.