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    Rnf44 ring finger protein 44 [ Mus musculus (house mouse) ]

    Gene ID: 105239, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rnf44provided by MGI
    Official Full Name
    ring finger protein 44provided by MGI
    Primary source
    MGI:MGI:2145310
    See related
    Ensembl:ENSMUSG00000034928 AllianceGenome:MGI:2145310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1100
    Summary
    Predicted to enable metal ion binding activity. Is expressed in several structures, including central nervous system; dorsal root ganglion; ear; male reproductive system; and urinary system. Orthologous to human RNF44 (ring finger protein 44). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 91.4), thymus adult (RPKM 80.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 B1; 13 28.94 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54827212..54841889, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54679399..54694076, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34588 Neighboring gene STARR-seq mESC enhancer starr_34589 Neighboring gene clathrin light chain B Neighboring gene STARR-seq mESC enhancer starr_34590 Neighboring gene STARR-seq mESC enhancer starr_34591 Neighboring gene Fas associated factor family member 2 Neighboring gene 4.5s RNA, pseudogene 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54788483-54788694 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54789238-54789421 Neighboring gene STARR-positive B cell enhancer ABC_E2408 Neighboring gene STARR-positive B cell enhancer ABC_E3083 Neighboring gene cadherin-related family member 2 Neighboring gene G protein-regulated inducer of neurite outgrowth 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 44

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146025.1 → NP_001139497.1  RING finger protein 44 isoform 1

      See identical proteins and their annotated locations for NP_001139497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK161651, BC017630, CF426263, CJ106658
      Consensus CDS
      CCDS49268.1
      UniProtKB/TrEMBL
      E9PUC0
      Related
      ENSMUSP00000118474.2, ENSMUST00000125871.8
      Conserved Domains (1) summary
      cd16680
      Location:371 → 432
      RING-H2_RNF44; RING finger, H2 subclass, found in RING finger protein 44 (RNF44) and similar proteins

    2. NM_001146026.1 → NP_001139498.1  RING finger protein 44 isoform 2

      See identical proteins and their annotated locations for NP_001139498.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK147349, BC017630, CF426263, CJ106658
      UniProtKB/Swiss-Prot
      Q3TAC8, Q3TVH9, Q3UHJ8, Q6ZPX8, Q8VD22
      Conserved Domains (1) summary
      pfam13639
      Location:355 → 396
      zf-RING_2; Ring finger domain

    3. NM_001146027.1 → NP_001139499.1  RING finger protein 44 isoform 3

      See identical proteins and their annotated locations for NP_001139499.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a segment of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK147349, BB841172, BC017630, CF426263, CF728349
      Consensus CDS
      CCDS49267.1
      UniProtKB/Swiss-Prot
      Q3UHJ8
      Related
      ENSMUSP00000123198.2, ENSMUST00000150806.8
      Conserved Domains (1) summary
      cd16472
      Location:296 → 340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    4. NM_134064.2 → NP_598825.2  RING finger protein 44 isoform 4

      See identical proteins and their annotated locations for NP_598825.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks a segment of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the mid coding region, compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AK160115, BC017630, CF426263, CJ106658
      Consensus CDS
      CCDS49266.1
      UniProtKB/Swiss-Prot
      Q3UHJ8
      Related
      ENSMUSP00000136732.2, ENSMUST00000177950.8
      Conserved Domains (1) summary
      cd16472
      Location:295 → 339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    RNA

    1. NR_027395.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) includes an alternate 5' exon and an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because it contains an upstream ORF that would inhibit the translation of the expected primary ORF, as found in variant 1. Translation of the upstream ORF would render this transcript a candidate for nonsense-mediated decay (NMD).
      Source sequence(s)
      BC017630, BY346776, CD349765, CF426263, CJ147978

    2. NR_027396.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) includes an alternate 5' exon and alternate splice sites in two internal exons, compared to variant 1. This variant is represented as non-coding because it contains an upstream ORF that would inhibit the translation of the expected primary ORF, as found in variant 1. Translation of the upstream ORF would render this transcript a candidate for nonsense-mediated decay (NMD).
      Source sequence(s)
      BC017630, BY346776, CD349765, CF426263

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      54827212..54841889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247093.1 → XP_030102953.1  RING finger protein 44 isoform X3

      Conserved Domains (1) summary
      cd16472
      Location:296 → 340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    2. XM_030247090.1 → XP_030102950.1  RING finger protein 44 isoform X3

      Conserved Domains (1) summary
      cd16472
      Location:296 → 340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    3. XM_030247097.2 → XP_030102957.1  RING finger protein 44 isoform X4

      Conserved Domains (1) summary
      cd16472
      Location:295 → 339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    4. XM_030247088.2 → XP_030102948.1  RING finger protein 44 isoform X2

      Conserved Domains (1) summary
      cd16472
      Location:376 → 420
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    5. XM_006517019.5 → XP_006517082.1  RING finger protein 44 isoform X1

      See identical proteins and their annotated locations for XP_006517082.1

      UniProtKB/TrEMBL
      E9PUC0
      Conserved Domains (1) summary
      cd16680
      Location:371 → 432
      RING-H2_RNF44; RING finger, H2 subclass, found in RING finger protein 44 (RNF44) and similar proteins

    6. XM_006517020.3 → XP_006517083.1  RING finger protein 44 isoform X2

      Conserved Domains (1) summary
      cd16472
      Location:376 → 420
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    7. XM_011244446.2 → XP_011242748.1  RING finger protein 44 isoform X1

      See identical proteins and their annotated locations for XP_011242748.1

      UniProtKB/TrEMBL
      E9PUC0
      Conserved Domains (1) summary
      cd16680
      Location:371 → 432
      RING-H2_RNF44; RING finger, H2 subclass, found in RING finger protein 44 (RNF44) and similar proteins

    8. XM_017315336.1 → XP_017170825.1  RING finger protein 44 isoform X3

      UniProtKB/Swiss-Prot
      Q3UHJ8
      Related
      ENSMUSP00000114259.2, ENSMUST00000134862.8
      Conserved Domains (1) summary
      cd16472
      Location:296 → 340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    9. XM_030247099.1 → XP_030102959.1  RING finger protein 44 isoform X4

      Related
      ENSMUSP00000043974.10, ENSMUST00000037422.16
      Conserved Domains (1) summary
      cd16472
      Location:295 → 339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    10. XM_030247089.1 → XP_030102949.1  RING finger protein 44 isoform X3

      Conserved Domains (1) summary
      cd16472
      Location:296 → 340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    11. XM_030247096.2 → XP_030102956.1  RING finger protein 44 isoform X4

      Conserved Domains (1) summary
      cd16472
      Location:295 → 339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    12. XM_011244450.1 → XP_011242752.1  RING finger protein 44 isoform X3

      See identical proteins and their annotated locations for XP_011242752.1

      UniProtKB/Swiss-Prot
      Q3UHJ8
      Conserved Domains (1) summary
      cd16472
      Location:296 → 340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    13. XM_006517018.5 → XP_006517081.1  RING finger protein 44 isoform X1

      See identical proteins and their annotated locations for XP_006517081.1

      UniProtKB/TrEMBL
      E9PUC0
      Conserved Domains (1) summary
      cd16680
      Location:371 → 432
      RING-H2_RNF44; RING finger, H2 subclass, found in RING finger protein 44 (RNF44) and similar proteins

    14. XM_030247087.1 → XP_030102947.1  RING finger protein 44 isoform X2

      Conserved Domains (1) summary
      cd16472
      Location:376 → 420
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    15. XM_011244447.1 → XP_011242749.1  RING finger protein 44 isoform X1

      See identical proteins and their annotated locations for XP_011242749.1

      UniProtKB/TrEMBL
      E9PUC0
      Conserved Domains (1) summary
      cd16680
      Location:371 → 432
      RING-H2_RNF44; RING finger, H2 subclass, found in RING finger protein 44 (RNF44) and similar proteins

    16. XM_030247095.2 → XP_030102955.1  RING finger protein 44 isoform X4

      Related
      ENSMUSP00000116850.2, ENSMUST00000128257.8
      Conserved Domains (1) summary
      cd16472
      Location:295 → 339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    17. XM_030247100.1 → XP_030102960.1  RING finger protein 44 isoform X4

      Conserved Domains (1) summary
      cd16472
      Location:295 → 339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    18. XM_030247092.1 → XP_030102952.1  RING finger protein 44 isoform X3

      Conserved Domains (1) summary
      cd16472
      Location:296 → 340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    19. XM_011244449.2 → XP_011242751.1  RING finger protein 44 isoform X3

      See identical proteins and their annotated locations for XP_011242751.1

      UniProtKB/Swiss-Prot
      Q3UHJ8
      Conserved Domains (1) summary
      cd16472
      Location:296 → 340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    20. XM_030247085.2 → XP_030102945.1  RING finger protein 44 isoform X2

      Conserved Domains (1) summary
      cd16472
      Location:376 → 420
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    21. XM_030247091.1 → XP_030102951.1  RING finger protein 44 isoform X3

      Conserved Domains (1) summary
      cd16472
      Location:296 → 340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    22. XM_011244451.1 → XP_011242753.1  RING finger protein 44 isoform X4

      See identical proteins and their annotated locations for XP_011242753.1

      UniProtKB/Swiss-Prot
      Q3UHJ8
      Conserved Domains (1) summary
      cd16472
      Location:295 → 339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    23. XM_036157809.1 → XP_036013702.1  RING finger protein 44 isoform X3

      Conserved Domains (1) summary
      cd16472
      Location:296 → 340
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

    24. XM_030247098.1 → XP_030102958.1  RING finger protein 44 isoform X4

      Conserved Domains (1) summary
      cd16472
      Location:295 → 339
      RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHJ8.1 GenPept UniProtKB/Swiss-Prot:Q3UHJ8

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