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    Dnal1 dynein, axonemal, light chain 1 [ Mus musculus (house mouse) ]

    Gene ID: 105000, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dnal1provided by MGI
    Official Full Name
    dynein, axonemal, light chain 1provided by MGI
    Primary source
    MGI:MGI:1921462
    See related
    Ensembl:ENSMUSG00000042523 AllianceGenome:MGI:1921462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnalc1; 1700010H15Rik; E330027P08Rik
    Summary
    Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be located in cell projection and microtubule. Predicted to be part of outer dynein arm. Predicted to be active in cytoplasm. Is expressed in brain ependyma; node; and upper respiratory tract epithelium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 16. Orthologous to human DNAL1 (dynein axonemal light chain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 11.8), cortex adult (RPKM 9.6) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 D1; 12 39.05 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84161057..84190291)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84114279..84143517)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32724 Neighboring gene acyl-CoA thioesterase 5 pseudogene Neighboring gene acyl-CoA thioesterase 6 Neighboring gene paraneoplastic antigen MA1 Neighboring gene mitotic deacetylase associated SANT domain protein Neighboring gene predicted gene, 40476

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients. Horváth J, et al. Am J Respir Cell Mol Biol, 2005 Jul. PMID 15845866
    2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the human (DNAL1) and murine (Dnal1) orthologs of the Chlamydomonas LC1-gene
      Title: Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159095, MGC159097

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein heavy chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of outer dynein arm ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein axonemal light chain 1
    Names
    dynein light chain 1, axonemal

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346528.1 → NP_001333457.1  dynein axonemal light chain 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125071, AK005826, CF540410
      Consensus CDS
      CCDS83987.1
      UniProtKB/Swiss-Prot
      Q05A62
      Related
      ENSMUSP00000037076.3, ENSMUST00000046340.9

    2. NM_028821.3 → NP_083097.2  dynein axonemal light chain 1 isoform 1

      See identical proteins and their annotated locations for NP_083097.2

      Status: VALIDATED

      Source sequence(s)
      AC125071, BC070454, BY126068
      Consensus CDS
      CCDS26039.2
      UniProtKB/Swiss-Prot
      A0JLX1, Q05A62, Q9DAH9
      Related
      ENSMUSP00000121038.2, ENSMUST00000123491.8
      Conserved Domains (4) summary
      sd00031
      Location:50 → 71
      LRR_1; leucine-rich repeat [structural motif]
      sd00035
      Location:95 → 116
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam12799
      Location:49 → 89
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:70 → 127
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84161057..84190291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515370.5 → XP_006515433.1  dynein axonemal light chain 1 isoform X1

      Conserved Domains (3) summary
      COG4886
      Location:24 → 141
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:37 → 58
      LRR_1; leucine-rich repeat [structural motif]
      sd00035
      Location:82 → 103
      LRR_NTF; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05A62.2 GenPept UniProtKB/Swiss-Prot:Q05A62

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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