Adi1 acireductone dioxygenase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adi1provided by MGI
Official Full Name: acireductone dioxygenase 1provided by MGI
Primary source: MGI:MGI:2144929
See related: Ensembl:ENSMUSG00000020629 AllianceGenome:MGI:2144929
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARD'; Fe-ARD; Ni-ARD; MTCBP-1
Summary: Predicted to enable acireductone dioxygenase [iron(II)-requiring] activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to act upstream of or within methionine biosynthetic process. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; integumental system; liver; respiratory system; and sensory organ. Orthologous to human ADI1 (acireductone dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver adult (RPKM 15.6), placenta adult (RPKM 14.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A2; 12 11.05 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (28725206..28732174)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (28675207..28682175)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal structure of acireductone dioxygenase (ARD) was determined to 2.06 A resolution using the multi-wavelength anomalous diffraction (MAD) method and the structure show nine beta-strands, five helices, and a metal-binding site inside the -barrel.
Title: Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 angstrom resolution.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125500 (e-PCR)
- UniSTS:162318

13.MMHAP76FRE7.seq (e-PCR)
- UniSTS:123183

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acireductone dioxygenase (Ni2+-requiring) activity	IEA Inferred from Electronic Annotation more info
enables acireductone dioxygenase [iron(II)-requiring] activity	IBA Inferred from Biological aspect of Ancestor more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-methionine salvage from methylthioadenosine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methionine metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acireductone dioxygenase

Names: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; ARD; aci-reductone dioxygenase; acireductone dioxygenase (Fe(2+)-requiring); acireductone dioxygenase (Ni(2+)-requiring); fe-ARD; membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1

NP_598813.1

EC 1.13.11.53

EC 1.13.11.54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.