U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Rab15 RAB15, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 104886, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rab15provided by MGI
    Official Full Name
    RAB15, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:1916865
    See related
    Ensembl:ENSMUSG00000021062 AllianceGenome:MGI:1916865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310012G06Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; protein localization to plasma membrane; and secretion by cell. Predicted to act upstream of or within protein transport. Predicted to be located in cilium; endosome membrane; and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and plasma membrane. Is expressed in several structures, including 1st branchial arch; cerebellum external granule cell layer; embryo endoderm; neural tube; and vibrissa. Orthologous to human RAB15 (RAB15, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon adult (RPKM 9.0), cortex adult (RPKM 7.7) and 19 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    12 C3; 12 33.73 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76844734..76869532, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76797960..76822759, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32533 Neighboring gene churchill domain containing 1 Neighboring gene glutathione peroxidase 2 Neighboring gene STARR-seq mESC enhancer starr_32534 Neighboring gene predicted gene, 34988 Neighboring gene STARR-positive B cell enhancer ABC_E2389 Neighboring gene farnesyltransferase, CAAX box, beta Neighboring gene predicted gene, 46357 Neighboring gene predicted gene, 46358 Neighboring gene STARR-seq mESC enhancer starr_32542

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord. Lai HC, et al. J Neurosci, 2011 Jul 27. PMID 21795538, Free PMC Article
    2. Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Pyrgaki C, et al. Dev Biol, 2011 May 1. PMID 21377456, Free PMC Article
    3. A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Walentin K, et al. Development, 2015 Mar 15. PMID 25758223, Free PMC Article
    4. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Sherwood RI, et al. Dev Biol, 2007 Apr 15. PMID 17328885
    5. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. Fukuda M, et al. J Biol Chem, 2002 Apr 5. PMID 11856727

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of regulated secretory pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ras-related protein Rab-15

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347405.1 → NP_001334334.1  ras-related protein Rab-15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132331, AI840042, AK158637, AK158768
      Consensus CDS
      CCDS83970.1
      UniProtKB/TrEMBL
      D3YTZ8, D3YWS1
      Related
      ENSMUSP00000113299.2, ENSMUST00000121716.8
      Conserved Domains (1) summary
      cl38936
      Location:1 → 126
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001347406.1 → NP_001334335.1  ras-related protein Rab-15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132331, AI840042, AK158637, AK158768
      Consensus CDS
      CCDS83970.1
      UniProtKB/TrEMBL
      D3YTZ8, D3YWS1
      Related
      ENSMUSP00000112789.2, ENSMUST00000118604.8
      Conserved Domains (1) summary
      cl38936
      Location:1 → 126
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001347407.1 → NP_001334336.1  ras-related protein Rab-15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI840042, AK158637, AK158768, BY239543
      Consensus CDS
      CCDS83970.1
      UniProtKB/TrEMBL
      D3YTZ8, D3YWS1
      Conserved Domains (1) summary
      cl38936
      Location:1 → 126
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_134050.5 → NP_598811.3  ras-related protein Rab-15 isoform 1

      See identical proteins and their annotated locations for NP_598811.3

      Status: VALIDATED

      Source sequence(s)
      AI840042, AK158637, AK158768, BY237353
      Consensus CDS
      CCDS25997.1
      UniProtKB/Swiss-Prot
      Q8K386
      UniProtKB/TrEMBL
      Q0PD40, Q3TYH2
      Related
      ENSMUSP00000021459.8, ENSMUST00000021459.14
      Conserved Domains (1) summary
      cd04117
      Location:9 → 172
      Rab15; Rab GTPase family 15 (Rab15)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      76844734..76869532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_381469.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K386.1 GenPept UniProtKB/Swiss-Prot:Q8K386

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous